Sarcoplasmic Reticulum Ca²⁺ Dysregulation in the Pathophysiology of Inherited Arrhythmia: An Update

The authors summarize normal sarcoplasmic reticulum (SR) Ca2+ regulation in cardiomyocytes, mechanisms of how Ca2+ triggers arrhythmias and involvements of SR gene mutations in inherited arrhythmias as well as the possible arrhythmogenic effects of these mutations.