CRL2^KLHDC3 Mediates p14ARF N-terminal Ubiquitylation Degradation to Promote Non-Small Cell Lung Carcinoma Progression

Kelch domain containing 3 (KLHDC3) shortage significantly increased the sensitivity of lung cancer cells to epidermal growth factor receptor-targeted drugs, providing an alternative explanation for the development of Gefitinib and Osimertinib resistance in NSCLC therapy.