Protective Autophagy Decreases Lorlatinib Cytotoxicity through Foxo3a-Dependent Inhibition of Apoptosis in NSCLC

The efficacy of chloroquine in combination with lorlatinib in anaplastic lymphoma kinase-positive NSCLC cells in vitro and in vivo was assessed using CCK-8, colony formation, immunofluorescence staining, flow cytometry analysis, western blot analysis, and xenograft implantation.