Umbilical & Placental Cell News

[Nature] In mice, IL-33 deficiency severely attenuated inflammation- and lymphotoxin (LT)–LTβ receptor-activation-induced tertiary lymphoid structures in models of colitis and PDAC.

[Scientific Reports] Through transcriptomic and single-cell RNA sequencing analyses, researchers explored metabolic pathway enrichment, immune infiltration patterns, and differential gene expression in prostate cancer samples.

[Ontario Newsroom] The Ontario government is connecting more people to care by being the first Canadian jurisdiction to publicly fund and administer PLUVICTO™ a new treatment for advanced-stage prostate cancer, which is now covered under the province’s publicly funded drug program.

[Stem Cell Reports] Scientists isolated and characterized guinea pig epiblast stem cells from post-implantation embryos. These cells differentiated into the three germ layers, maintained normal karyotypes, and relied on FGF2 and ACTIVIN A signaling for self-renewal and pluripotency.

[Small] The Under-oil Open Microfluidic System microtumor model – allowing a controlled but also self-organized, cell-directed tumor-ECM microenvironment in an open microfluidic configuration – was used to test an anti-metastasis drug with a triple-negative breast cancer cell line.

[Blood] The authors discuss the current molecular landscape and functional characterization of three of the most lethal childhood AML fusion-oncogene driven subtypes harboring KMT2A, NUP98, or CBFA2T3::GLIS2 rearrangements.

[Proceedings of The National Academy of Sciences of The United States of America] Scientists investigated the role of ADARp110 in hepatocellular carcinoma and underlying mechanisms using clinical samples, a hepatocyte-specific Adarp110 knock-in mouse model, and engineered cell lines.

[Communications Biology] The authors found that PLAC8 was downregulated in the lungs of idopathic pulmonary fibrosis patients, in bleomycin-induced lungs of mice, and in primary murine alveolar epithelial type II cells and human lung epithelial cell A549 cells.

[BMC Ophthalmology] Corneal organoids were generated from hiPSCs derived from aniridia patients with three different paired-box gene 6 nonsense mutations, allowing for a detailed comparison between diseased and healthy control models.

[Nature Medicine] Investigators developed in vivo cytosine and adenine base strategies delivered by adeno-associated viruses to permanently modify the PRNP locus to achieve prion protein knockdown in the mouse brain.

[Nature] Scientists revealed that the transcription factors SOX4, SOX11 and TFAP2D had a pivotal role in the development, identity, and prefrontal cortex connectivity of ventrolateral pallial neurons.

[Eisai Co., Ltd.] Eisai Co., Ltd. and Biogen Inc.announced that the US FDA has accepted Eisai’s Biologics License Application for lecanemab-irmb subcutaneous autoinjector for weekly maintenance dosing.