Umbilical & Placental Cell News
[Scientific Reports] Scientists identified miRNA that were up-regulated in satellite cell-derived myoblasts treated with stromal derived factor-1 (SDF-1) and/or down-regulated in cells in which the expression of CXCR4 or CXCR7, that is, SDF-1 receptors, was silenced.
[Cell Death & Disease] Investigators revealed that Krüppel-like factor 4 (KLF4) played a critical role in skeletal muscle development and regeneration. Specific knockout of KLF4 in skeletal muscle impaired muscle formation further affecting physical activity and also defected skeletal muscle regeneration.
Aberrant Gene Activation in Synovial Sarcoma Relies on SSX Specificity and Increased PRC1.1 Stability
[Nature Structural & Molecular Biology] Scientists showed that the ability of SS18-SSX to occupy H2AK119ub1-rich regions was an intrinsic property of its SSX C terminus, which could be exploited by fusion to transcriptional regulators beyond SS18.
Establishing an hTERT-Driven Immortalized Umbilical Cord-Derived Mesenchymal Stem Cell Line and Its Therapeutic Application in Mice with Liver Failure
[Journal of Tissue Engineering] To achieve mass production and quality control on stem cells and their exosomes, transfecting umbilical cord MSC (UCMSC) with lentivirus overexpressing human telomerase reverse transcriptase (hTERT) gene, the hTERT-UCMSC was constructed as an immortalized MSC cell line.
[Scientific Reports] The authors demonstrated that cellular heterogeneity could be highly dynamic and dependent on the micromechanical properties of the substrate.
Microglia-Dependent Neuroprotective Effects of 4-Octyl Itaconate Against Rotenone– and MPP+–Induced Neurotoxicity in Parkinson’s Disease
[Scientific Reports] Researchers investigated the neuroprotective potential of 4-octyl itaconate, a cell-permeable derivative of itaconate, in cellular models of Parkinson’s disease.
Stem Cells-Derived Exosomes Alleviate Neurodegeneration and Alzheimer’s Pathogenesis by Ameliorating Neuroinflamation, and Regulating the Associated Molecular Pathways
[Scientific Reports] Investigators examined how NSC-exos could protect human neuroblastoma cells SH-SY5Y. NSC-exos were derived from human NSCs by ultracentrifugation and the therapeutic effects of the NSC-exos were then investigated in vitro.
[Nature Methods] Scientists combined optogenetics and gene perturbation technologies to activate or knock-down RNA of target genes in programmable spatiotemporal patterns.
Lung Tumor–Infiltrating Treg Have Divergent Transcriptional Profiles and Function Linked to Checkpoint Blockade Response
[Science Immunology] Researchers identified 10 subsets of human tumor-infiltrating-Treg, most of which had high concordance with murine tumor-infiltrating-Treg subsets.
[Cell Metabolism] Scientists identified a stem cell-like CD7+ monocyte subpopulation accumulating in the bone marrow of mice and humans that experienced dieting-induced weight loss.
[Nature] The authors showed a new link between the stress-associated catecholamines and the progression of T cell exhaustion through the β1-adrenergic receptor ADRB1.
[Nature] Investigators showed that proliferating effector CD8+ T cells reductively carboxylated glutamine through the mitochondrial enzyme isocitrate dehydrogenase 2.