Umbilical & Placental Cell News

[Scientific Reports] Scientists identified miRNA that were up-regulated in satellite cell-derived myoblasts treated with stromal derived factor-1 (SDF-1) and/or down-regulated in cells in which the expression of CXCR4 or CXCR7, that is, SDF-1 receptors, was silenced.

[Cell Death & Disease] Investigators revealed that Krüppel-like factor 4 (KLF4) played a critical role in skeletal muscle development and regeneration. Specific knockout of KLF4 in skeletal muscle impaired muscle formation further affecting physical activity and also defected skeletal muscle regeneration.

[Nature Structural & Molecular Biology] Scientists showed that the ability of SS18-SSX to occupy H2AK119ub1-rich regions was an intrinsic property of its SSX C terminus, which could be exploited by fusion to transcriptional regulators beyond SS18.

[Journal of Tissue Engineering] To achieve mass production and quality control on stem cells and their exosomes, transfecting umbilical cord MSC (UCMSC) with lentivirus overexpressing human telomerase reverse transcriptase (hTERT) gene, the hTERT-UCMSC was constructed as an immortalized MSC cell line.

[Scientific Reports] The authors demonstrated that cellular heterogeneity could be highly dynamic and dependent on the micromechanical properties of the substrate.

[Scientific Reports] Researchers investigated the neuroprotective potential of 4-octyl itaconate, a cell-permeable derivative of itaconate, in cellular models of Parkinson’s disease.

[Scientific Reports] Investigators examined how NSC-exos could protect human neuroblastoma cells SH-SY5Y. NSC-exos were derived from human NSCs by ultracentrifugation and the therapeutic effects of the NSC-exos were then investigated in vitro.

[Nature Methods] Scientists combined optogenetics and gene perturbation technologies to activate or knock-down RNA of target genes in programmable spatiotemporal patterns.

[Science Immunology] Researchers identified 10 subsets of human tumor-infiltrating-Treg, most of which had high concordance with murine tumor-infiltrating-Treg subsets.

[Cell Metabolism] Scientists identified a stem cell-like CD7+ monocyte subpopulation accumulating in the bone marrow of mice and humans that experienced dieting-induced weight loss.

[Nature] The authors showed a new link between the stress-associated catecholamines and the progression of T cell exhaustion through the β1-adrenergic receptor ADRB1.

[Nature] Investigators showed that proliferating effector CD8+ T cells reductively carboxylated glutamine through the mitochondrial enzyme isocitrate dehydrogenase 2.