Umbilical & Placental Cell News

TGFβ in Pancreas and Colorectal Cancer: Opportunities to Overcome Therapeutic Resistance

[Clinical Cancer Research] Scientists review the current TGFβ inhibitor drugs in clinical trials for pancreatic and colorectal cancer, with the goal of uncovering advances in improving clinical efficacy for TGFβ combinational treatments in patients.

The Epithelial C15ORF48/miR-147-NDUFA4 Axis Is an Essential Regulator of Gut Inflammation, Energy Metabolism, and the Microbiome

[Proceedings of The National Academy of Sciences of The United States of America] Researchers uncovered C15ORF48/miR-147 as a negative regulator of gut inflammation, operating through the modulation of epithelial cell metabolism.

Phase II Trial of Pembrolizumab, Ipilimumab, and Aspirin in Melanoma: Clinical Outcomes and Translational Predictors of Response

[BJC reports] Investigators conducted the first prospective phase II single-arm study of combination high-dose aspirin with standard of care ipilimumab and pembrolizumab for patients with advanced/metastatic melanoma to determine safety and efficacy of COX inhibition when combined with immune checkpoint inhibitors.

Perforation-Type Anchors Inspired by Skin Ligament for Robotic Face Covered with Living Skin

[Cell Reports Physical Science] Scientists developed and characterized perforation-type anchors inspired by the structure of skin ligaments as a technique to effectively adhere skin equivalents to robotic surfaces. They constructed a robotic face covered with dermis equivalent, capable of expressing smiles, with actuation through perforation-type anchors.

MicroRNA-7 Regulates Endocrine Progenitor Delamination and Endocrine Cell Mass in Developing Pancreatic Islets

[iScience] The authors showed that microRNA-7 (miR-7) was highly expressed in embryonic pancreatic endocrine progenitors. Genetic deletion of the miR-7 gene family in endocrine progenitors led to reduced islet endocrine cell mass, due to endocrine progenitors failing to delaminate from the epithelial plexus.

Targeting the Intestinal Circadian Clock by Meal Timing Ameliorates Gastrointestinal Inflammation

[Cellular & Molecular Immunology] A lack of the intestinal clock gene in intestinal epithelial cells in a chemically and a novel genetically induced colitis model promoted colitis and dramatically reduced survival rates.

HNF4A and HNF1A Exhibit Tissue Specific Target Gene Regulation in Pancreatic Beta Cells and Hepatocytes

[Nature Communications] To better define the pleiotropic gene regulatory roles of HNF4A and HNF1A, researchers generated a comprehensive genome-wide map of their binding targets in pancreatic and hepatic cells using ChIP-Seq. Functional follow-up highlighted a potential role for HAAO and USH1C as regulators of beta cell function.

N6-Methyladenosine Modified TGFB2 Triggers Lipid Metabolism Reprogramming to Confer Pancreatic Ductal Adenocarcinoma Gemcitabine Resistance

[Oncogene] Employing an integrated approach involving bioinformatic analyses from multiple databases, transforming growth factor-beta 2 (TGFB2) was identified as a crucial gene in gemcitabine-resistant PDAC and was significantly associated with poor gemcitabine therapeutic response.

SMAD4 Depletion Contributes to Endocrine Resistance by Integrating ER and ERBB Signaling in HR + HER2− Breast Cancer

[Cell Death & Disease] Researchers investigated the role of SMAD4 in acquired endocrine resistance in hormone receptor-positive and HER2-negative breast cancer. Functional studies demonstrated that SMAD4 depletion induced endocrine resistance in vitro and in vivo by enhancing ER and ERBB signaling.

Selective Advantage of Mutant Stem Cells in Human Clonal Hematopoiesis Is Associated with Attenuated Response to Inflammation and Aging

[Cell Stem Cell] To gain insight into how clonal hematopoiesis (CH) mutations enabled gradual clonal expansion, researchers used single-cell multi-omics with high-fidelity genotyping on human CH bone marrow samples.

Biologic and Clinical Analysis of Childhood Gamma Delta T-ALL Identifies LMO2/STAG2 Rearrangements as Extremely High-Risk

[Cancer Discovery] Scientists studied 200 children with acute lymphoblastic leukemia expressing the gamma delta T cell receptor from 13 clinical study groups to understand the clinical and genetic features of this disease.

Signaling Proteins in HSC Fate Determination Are Unequally Segregated during Asymmetric Cell Division

[Journal of Cell Biology] Investigators showed that activation of MEK/ERK and mTORC1 pathways was spatially segregated in premitotic HSCs and unequally inherited during asymmetric cell division.