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Organoid News is an online resource dedicated to the latest research about and featuring organoids.
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Human PSC-Derived Organoids Model Sympathetic Ganglion Development and Its Functional Crosstalk with the Heart
[Cell Stem Cell] The authors reported a method to differentiate hPSCs into 3D neural organoids that resemble peripheral sympathetic ganglia, producing both neurons and glial cells of the ganglia in a self-organized manner.
Patient-Derived Colon Epithelial Organoids Reveal Lipid-Related Metabolic Dysfunction in Pediatric Ulcerative Colitis
[Nature Communications] Scientists demonstrated that active ulcerative colitis colonoids exhibit hypermetabolic features and cellular stress, specifically during differentiation.
Effectiveness of Multivitamins vs Folic Acid on Prevention of Neural Tube Defects in Mouse Genetic Models and Human Organoids
[Advanced Science] Human iPSC-derived neuroectoderm organoids were generated with an elliptical shape resembling the human neural tube and cranial to upper spinal identity.
Chimeric Human Organoid and Mouse Brain Slice Co-Cultures to Study Microglial Function
[Cell Reports] Researchers developed a chimeric model by co-culturing hiPSC-derived organoids (hORGs) with mouse brain slice cultures. This system reveals cross-species interactions associated with an earlier onset of cortical neuronal differentiation markers in the hORGs.
Cerebral Organoids Expressing Mutant Actin Genes Reveal Cellular Mechanism Underlying Microcephaly
[EMBO Reports] The authors studied patient-derived cerebral organoids from iPSCs of individuals with the Baraitser–Winter-CerebroFrontoFacial syndrome carrying an ACTB/ACTG1 missense mutation.
Colorectal Cancer Organoids Drive Hypoxia, TGF-β, and Patient-Specific Diversification of NK Cell Activation Programs
[Journal of Immunotherapy of Cancer] Investigators established a co-culture platform of genetically diverse colorectal cancer patient-derived organoids with primary allogeneic NK cells.
Organoid-Derived Photoreceptor Precursors Enriched by CD9⁻CD81mid Sorting Restore Visual Function in RCS Rats
[Stem Cell Research & Therapy] Researchers analyzed single-cell RNA sequencing datasets of human retinal organoids to identify photoreceptor-specific surface markers and validated them by immunofluorescence and flow cytometry.
Autophagy Is Required for the Development and Functionality of Lacrimal Gland-Like Organoids
[Stem Cell Reports] The authors undertook a genetic study by utilizing autophagy-deficient hESCs and differentiating them into lacrimal glands-like organoids.
Austrian Science Fund (FWF) Supports Two IMBA Research Projects
[Institute of Molecular Biotechnology (IMBA)] The FWF has awarded two grants to IMBA scientists. The projects, led by Jürgen Knoblich and Nicolas Rivron, will use stem cell-based models to advance our knowledge of cell transplantation therapies and human implantation, respectively.
Mapping Human Neurodevelopment-Brain Organoids Meet Lineage Tracing
[FEBS Letters] Scientists review the current state of the art regarding the application of brain organoids for understanding human developmental processes related to cell lineage and temporal progression, highlighting studies that have developed dedicated lineage tracing tools.
Organoids As a New Approach in Advancing Cancer Therapies for Hematologic Malignancies
[Biochimica Et Biophysica Acta-Reviews On Cancer] Scientists introduce hematologic organoids and how bone marrow, lymph nodes, thymus, and spleen organoids can replicate the hematologic malignancies for personalized therapies and research studies.
Cadherin-1-Mediated Communication at the Leader-Follower Boundary Controls Mouse Breast Tumor Organoid Collective Migration
[Cell Reports] Through 3D computational simulations and live video 3D imaging of primary mouse breast tumor organoids in a microfluidic device, researchers investigated the roles of type I cadherins during collective migration.
Organoids are three-dimensional cell cultures that more accurately model cell behavior, organ function, and pathology than traditional two-dimensional cell culture. Organoid News was launched in 2020 to help scientists stay up-to-date with this revolutionary new research system. Use Organoid News to stay current with the latest applications and discoveries using organoids, as well as new reviews, jobs, news, and upcoming events.
