Organoid News

Organoid News is an online resource dedicated to the latest research about and featuring organoids.

High-Throughput Drug Screening Identifies EGFR/MAPK Pathway Targeting Sensitivities in Organoid Models of Ovarian Carcinosarcoma

January 7, 2026

[Journal of Experimental & Clinical Cancer Research] Researchers carried out drug screens in the presence of cisplatin or eribulin to identify synergistic combinations. They validated the top combinations in their unique ovarian carcinosarcoma cell line, organoid, and patient-derived xenograph models.

Patient-Derived Organoids Predict Responses to Chemotherapy and PARP Inhibitors in Advanced Ovarian Cancer

January 7, 2026

[Journal of Translational Medicine] Patient-derived organoids were established from treatment-naive epithelial ovarian cancer specimens and characterized by H&E staining, immunohistochemistry, and whole-exome sequencing.

Formation of an Endometrial Epithelial Monolayer in a Microfluidic Device with Human Tissue-Derived Endometrial Organoids

January 7, 2026

[Lab on a Chip] Scientists built a microfluidic model of the human endometrial epithelium using patient-derived organoids and defined a parameterized device and ECM conditions that yield a stable, polarized monolayer on chip.

Optimized Patient-Derived Lung Cancer Organoids Recapitulating the Immune Landscape for Precision Therapy Evaluation

January 7, 2026

[Cellular Oncology] Investigators developed an optimized air-liquid interface culture method to generate patient-derived lung cancer organoids from 19 lung cancer samples.

Application of HepG2-Derived Organoid and Organ-on-a-Chip Platforms in Elucidating Selenium-Mediated Protection against Cadmium-Induced Liver Dysfunction

January 7, 2026

[NPJ Science of Food] HepG2 cells were cultured into liver organoids and integrated into a microfluidic chip, which regulates flow, nutrients, and waste to simulate in vivo hepatic microcirculation.

Development and Validation of Deep Learning for Predicting the Growth of Ovarian Cancer Organoids

January 7, 2026

[Chinese Medical Journal] Researchers developed an interpretable deep learning-based model to predict the cultivation outcome of ovarian cancer organoids in advance.

Patient-Derived 3D Organoid Platform for Functional Assessment of GPC3-Targeted CAR T Cell Cytotoxic Activity in Head and Neck Squamous Cell Carcinoma

January 7, 2026

[Oral Oncology] Scientists established a simplified and optimized 3D head and neck cancer organoid –chimeric antigen receptor T cell co-culture platform that maintains uniform spheroid architecture to recapitulate physiological hypoxia while preserving the tumor secretome.

Investigating the Neurodevelopmental Toxicity of Graphene Oxides Using 3D Human Brain Organoids and Zebrafish Models: Emphasis on GABAergic Neuron Alterations at Single-Cell Resolution

January 7, 2026

[Chemico-Biological Interactions] Investigators utilized 3D human brain organoids and zebrafish larvae to investigate grapheve oxide-induced neurodevelopmental toxicity.

A Human Lung Organoid Platform for Studying Radiation-Induced Pulmonary Fibrosis and Antifibrotic Drug Screening

January 7, 2026

[Scientific Reports] Researchers established a human embryonic stem cells-derived human lung organoids model, comprising major epithelial cell types, including AT1, AT2, goblet, basal, club, and ciliated cells.

Integrative Bioengineering Strategies for Endometrial Regeneration: From Biomaterials and Stem Cells to Organoids and Organ-on-a-Chip Technologies

January 7, 2026

[Theranostics] The authors comprehensively examines integrative bioengineering strategies for endometrial regeneration, focusing on the synergistic applications of biomaterials, stem cells, organoids, and organ-on-a-chip technologies.

Novoron Bioscience Awarded $2.5 Million NIH/NIA SBIR Grant to Accelerate Alzheimer’s Drug Discovery with Human Brain Organoids

January 7, 2026

[Novoron Bioscience (PR Newswire)] Novoron Bioscience has received a $2.5 million Small Business Innovation Research (SBIR) grant from the National Institute on Aging at the National Institutes of Health.

Hematopoietic Organoids: Opportunities and Challenges in Modeling Human Hematopoiesis and Diseases In Vitro

January 6, 2026

[Stem Cell Reports] The authors summarize recent progress in hematopoietic organoid (HO) construction, explore their potential applications in both basic research and clinical translation, and discuss current opportunities and remaining challenges in generating physiologically relevant HO models.

Organoids are three-dimensional cell cultures that more accurately model cell behavior, organ function, and pathology than traditional two-dimensional cell culture. Organoid News was launched in 2020 to help scientists stay up-to-date with this revolutionary new research system. Use Organoid News to stay current with the latest applications and discoveries using organoids, as well as new reviews, jobs, news, and upcoming events.