SARS-CoV-2 Productively Infects Human Gut Enterocytes

In human small intestinal organoids, enterocytes were readily infected by SARS-CoV and SARS-CoV-2, as demonstrated by confocal and electron microscopy.
[Science]
Lamers, M. M., Beumer, J., Vaart, J. van der, Knoops, K., Puschhof, J., Breugem, T. I., Ravelli, R. B. G., Schayck, J. P. van, Mykytyn, A. Z., Duimel, H. Q., Donselaar, E. van, Riesebosch, S., Kuijpers, H. J. H., Schipper, D., Wetering, W. J. van de, Graaf, M. de, Koopmans, M., Cuppen, E., Peters, P. J., … Clevers, H. (2020). SARS-CoV-2 productively infects human gut enterocytes. Science, 369(6499), 50–54. https://doi.org/10.1126/science.abc1669 Cite
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Amidst Uncertainty, Flexibility Is Key in Higher Ed, Faculty Say

Life sciences professors and other staff make contingency plans for more coronavirus-related disruptions in the coming school year.
[The Scientist]
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United Kingdom Plans ‘Office for Talent’ to Smooth Entry for Top Scientists

The UK government plans to set up an “office for talent” to oversee visas and make it easier to attract top scientists after Brexit, according to an R&D road map.
[ScienceInsider]
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Hong Kong Universities Rattled by New Security Law

Academics in Hong Kong are facing new worries today after the mainland government abruptly imposed a controversial new security law that critics say could infringe on human rights and chill academic freedom.
[ScienceInsider]
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CDK5RAP3 as Tumor Suppressor Negatively Regulates Self-Renewal and Invasion and Is Regulated by ERK1/2 Signaling in Human Gastric Cancer

Researchers showed that CDK5 regulatory subunit-associated protein 3 was weakly expressed in gastric cancer stem-like cells (CSCs) and was negatively correlated with the gastric CSC marker CD44.
[British Journal of Cancer]
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Mucus Layer Modeling of Human Colonoids during Infection with Enteroaggragative E. coli

Investigators used human colonoids comprising goblet cells and a thick mucin barrier as an intestinal model to investigate Pic’s roles during infection with EAEC.
[Scientific Reports]
Liu, L., Saitz-Rojas, W., Smith, R., Gonyar, L., In, J. G., Kovbasnjuk, O., … Ruiz-Perez, F. (2020). Mucus layer modeling of human colonoids during infection with enteroaggragative E. coli. Scientific Reports, 10(1), 10533. https://doi.org/10.1038/s41598-020-67104-4 Cite
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NIH’s New Sexual-Harassment Rules Are Still Too Weak, Say Critics

On 24 June, the US National Institutes of Health (NIH) described the actions it will take when alerted to reports of unsafe behavior, including restricting scientists from peer-review panels, holding back pending grants and refusing university requests to transfer funding to other institutions in cases where a harasser changes jobs.
[Nature News]
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Cancer Cell Invasion of Mammary Organoids with Basal‐In Phenotype

Investigators described mammary organoids with a basal‐in phenotype where the basement membrane was located on the interior surface of the organoid.
[Advanced Healthcare Materials]
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Gender Gap in Research Output Widens during Pandemic

A series of recent studies has demonstrated a significant drop in the productivity of female scientists, especially those early in their careers, relative to their male peers—and the gender gap is particularly pronounced for COVID-19 researchers.
[The Scientist]
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Graduate Programs Drop GRE after Online Version Raises Concerns about Fairness

Scores of academics have raised concerns about the equity of the online version of the test, arguing it disadvantages prospective students from rural and low-income backgrounds. “If I were … a student trying to take this exam, satisfying [the online testing] criteria would be extremely difficult for me,” says Emily Levesque, an assistant professor of astronomy at the University of Washington, Seattle.
[ScienceInsider]
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COVID-19 Cancels Charity Galas and Walks. Science Is Paying the Price

Foundations that fund biomedical research in the United States, the United Kingdom, and elsewhere are reporting record revenue drops because of the pandemic. One major factor: It has forced them to cancel key fundraising events, including glitzy galas, sponsored walks, Broadway partnerships, and more.
[ScienceInsider]
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