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Organoid News is an online resource dedicated to the latest research about and featuring organoids.
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Retinal Ganglion Cell Survival and Functional Maturation in Transiently Vascularized Human Retinal Organoids
[Cell Stem Cell] Scientists incorporated stem cell-derived endothelial cells to induce transient vascular-like networks and used microfluidic devices to stabilize axonal growth. The resulting organoids showed reduced hypoxia, increased size, and decreased apoptosis, indicating improved long-term survival and maturation of retinal ganglion cells.
Dynamic Allele Usage of X-Linked Genes Ameliorates Neurodevelopmental Disease Phenotypes in Brain Organoids
[Nature Communications] Scientists used clonal human female induced pluripotent stem cells to track allele-specific expression of X-chromosomal genes along neural differentiation.
A Human Tumor-Immune Organoid Model of Glioblastoma
[Cell Reports] Researchers developed an immune-human organoid tumor transplantation model, an autologous co-culture platform that integrates patient-derived tumor cells and matched peripheral blood mononuclear cells within human cortical organoids to enable the study of patient-specific immune responses and tumor-immune interactions.
Hybrid Endometrial-Derived Hydrogel and Human Endometrial Organoids Synergize for Uterine Regeneration in an Immunocompetent Murine Model
[Stem Cell Research & Therapy] Researchers explored a dual regenerative strategy combining a hybrid hydrogel — composed of synthetic PuraMatrix® and endometrial extracellular matrix hydrogel — with human endometrial organoids in an immunocompetent murine model with uterine damage.
Does Mechanobiology Drive Respiratory Disease? Biomechanical Induction of Mucus Hypersecretion in Human Bronchial Organoids Using a Photocontrolled Biomaterial Gel
[Biomaterials Science] Researchers introduced a combined biomaterial and 3D-organoid model, based on a hybrid biomaterial-matrix double-network gel, whose mechanical properties are dynamically photocontrolled by the application of light.
Single Cell Transcriptomic Comparison of the Developing Human Fetal Stomach and Pluripotent Stem Cell-Derived Gastric Organoids
[Development] To determine the robustness of human antral gastric organoids (hAGOs) and how additional germ layers impact development, we benchmarked these hAGOs with the developing human stomach.
Evolution of the Lipidome Uncovers Early Changes in Adrenoleukodystrophy Human Cortical and Spinal Organoids
[iScience] To investigate lipid dynamics in central nervous system development and adrenoleukodystrophy pathogenesis, we generated hiPSC-derived cortical and spinal cord organoids and performed lipidomics over 200 days.
A miRNA Screen Reveals a Transcriptional Network Controlling the Initiation of Mammary Organoids
[FEBS Journal] Investigators revealed that miR-106a-3p acts as a central modulator of mammary epithelial plasticity, enriching for stem/progenitor-like cells, driving organoid expansion, fostering K14+/K19+ lineage intermixing, and promoting branching morphogenesis characteristic of early ductal development.
Evaluating Carboplatin and PARP Inhibitor Combination Efficacy Using High-Grade Serous Carcinoma Spheroids and Organoids
[Cancer Biology & Therapy] First-line carboplatin treatment remains ideal, yet there may be select utility for PARPi prior to chemotherapy. Using patient-derived tumor models such as spheroids and organoids may provide insights for on-going and future clinical trials to enhance therapeutic outcomes for high-grade serous carcinoma patients.
The Evolution of Endometriosis Research Models: A Paradigm Shift from Immortalized Cell Lines to Organoids†
[Biology of Reproduction] Investigators highlight the transformative potential of organoids in disease modeling, drug screening, and personalized therapy.
Vascularized Brain Organoids: Engineering Strategies and Neurobiological Applications
[Cell Proliferation] The authors explore how vascularization enhances the structural and physiological relevance of brain organoids and their growing significance in disease modeling and therapeutic screening.
Advances in Three-Dimensional Modeling of Ischemic Injury
[Journal of Cerebral Blood Flow and Metabolism] Scientists investigate the rapid advancement and growing body of research involving 3D brain models, particularly organoids and assembloids.
Organoids are three-dimensional cell cultures that more accurately model cell behavior, organ function, and pathology than traditional two-dimensional cell culture. Organoid News was launched in 2020 to help scientists stay up-to-date with this revolutionary new research system. Use Organoid News to stay current with the latest applications and discoveries using organoids, as well as new reviews, jobs, news, and upcoming events.
