Cancer Stem Cell News
Cell Therapy News
Dermal Cell News
Endothelial Cell News
ESC & iPSC News
Extracellular Matrix News
Hematopoiesis News
Hepatic Cell News
Human Immunology News
Immune Regulation News
Intestinal Cell News
Mammary Cell News
Mesenchymal Cell News
Muscle Cell News
Neural Cell News
Organoid News
Pancreatic Cell News
Prostate Cell News
Pulmonary Cell News
Organoid News
Organoid News is an online resource dedicated to the latest research about and featuring organoids.
Post-Gastrulation Amnioids As a Stem Cell-Derived Model of Human Extra-Embryonic Development
[Cell] Researchers presented an ESC-derived 3D model of the post-gastrulation amnion, post-gastrulation amnioids, that faithfully recapitulates extra-embryonic development up to four weeks post-fertilization, closely mimicking the functional traits of the human amniotic sac.
Establishing Dorsal-Ventral Patterning in Human Neural Tube Organoids with Synthetic Organizers
[Cell Stem Cell] The authors presented organizers derived from PSC aggregate fusion, a method that establishes opposing BMP and SHH gradients within neural ectodermal cell aggregates.
Diverse Bat Organoids Provide Pathophysiological Models for Zoonotic Viruses
[Science] Researchers developed a collection of bat organoid models spanning five species and four organ types. This multispecies, multiorgan organoid panel shows species- and tissue-specific replication patterns for several viruses, offering robust pathophysiological models for studying respiratory, renal, and enteric zoonotic viruses.
Engineered Hydrogels for Organoid Models of Human Nonalcoholic Fatty Liver Disease
[Advanced Science] An in vitro NAFLD model was developed using chemically defined, engineered hydrogels and hiPSC-derived hepatic organoids.
Digitalized Organoids: Integrated Pipeline for High-Speed 3D Analysis of Organoid Structures Using Multilevel Segmentation and Cellular Topology
[Nature Methods] Investigators introduced an AI-based multilevel segmentation and cellular topology pipeline for screening morphology and topology modifications in 3D cell culture at both the nuclear and cytoplasmic levels, as well as at the whole-organoid scale.
Bile Acid-FXR Signaling Facilitates the Long-Term Maintenance of Hepatic Characteristics in Human iPSC-Derived Organoids
[Cell Reports] Investigators developed a human iPSC-derived hepatic organoid culture system that effectively retains hepatic characteristics long term.
An Integrated Transcriptomic Cell Atlas of Human Endoderm-Derived Organoids
[Nature Genetics] Researchers integrated single-cell transcriptomes from 218 samples covering organoids and other models of diverse endoderm-derived tissues to establish an initial version of a human endoderm-derived organoid cell atlas.
Organoid Morphology-Guided Classification for Oral Cancer Reveals Prognosis
[Cell Reports Medicine] Scientists presented a pioneering approach to classifying oral cancer subtypes based on the morphology of patient-derived organoids and proposed a therapeutic strategy.
NIH to Prioritize Human-Based Research Technologies
[NIH] The NIH is adopting a new initiative to expand innovative, human-based science while reducing animal use in research. Developing and using cutting-edge alternative nonanimal research models aligns with the US FDA's recent initiative to reduce testing in animals.
Crown Bioscience and NEXT Oncology Cement Partnership Extension
[Crown Bioscience] Crown Bioscience announced the extension of its partnership with NEXT Oncology to leverage Crown Bioscience's extensive experience in developing clinically relevant cancer organoid and patient-derived xenograft models, together with NEXT Oncology's global clinical network and Phase I clinical trials expertise.
Specification of Human Brain Regions with Orthogonal Gradients of WNT and SHH in Organoids Reveals Patterning Variations across Cell Lines
[Cell Stem Cell] The authors designed the Dual Orthogonal-Morphogen Assisted Patterning System (Duo-MAPS) diffusion device to expose spheres of iPSCs to concomitant orthogonal gradients of a posteriorizing and a ventralizing morphogen, activating WNT and SHH signaling, respectively.
Patient-Derived Models of UBA5-Associated Encephalopathy Identify Defects in Neurodevelopment and Highlight Potential Therapeutic Avenues
[Science Translational Medicine] Investigators developed and characterized patient-derived cortical organoid cultures from two patients with compound heterozygous variants in UBA5.
Organoids are three-dimensional cell cultures that more accurately model cell behavior, organ function, and pathology than traditional two-dimensional cell culture. Organoid News was launched in 2020 to help scientists stay up-to-date with this revolutionary new research system. Use Organoid News to stay current with the latest applications and discoveries using organoids, as well as new reviews, jobs, news, and upcoming events.
