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Organoid News is an online resource dedicated to the latest research about and featuring organoids.
A Pancreatic Cancer Organoid-in-Matrix Platform Shows Distinct Sensitivities to T Cell Killing
[Scientific Reports] Investigators described an INTERaction with Organoid-in-MatriX model system, that presentd a 3D co-culture-based platform for investigating matrix-dependent cellular crosstalk. They describe its potential to uncover new molecular mechanisms of T cell responses to murine KPC pancreatic ductal adenocarcinoma (PDAC) cells as well as PDAC patient-derived organoids.
Antisense Oligonucleotide Therapeutic Approach for Timothy Syndrome
[Nature] Scientists developed antisense oligonucleotides (ASOs) to effectively decrease the inclusion of exon 8A in human cells. They discovered that the ASO-mediated switch from exon 8A to 8 robustly rescued defects in patient-derived cortical organoids and migration in forebrain assembloids.
Spatiotemporally Resolved Colorectal Oncogenesis in Mini-Colons Ex Vivo
[Nature] Researchers developed topobiologically complex mini-colons that were able to undergo tumorigenesis ex vivo by integrating microfabrication, optogenetic, and tissue engineering approaches.
Endogenous Mutant Huntingtin Alters the Corticogenesis via Lowering Golgi Recruiting ARF1 in Cortical Organoid
[Molecular Psychiatry] The authors replicated the altered corticogenesis in the Huntington’s disease (HD) fetal brain using HD patient-derived human cortical organoids.
Phototoxicity Avoidance Is a Potential Therapeutic Approach for Retinal Dystrophy Caused by EYS Dysfunction
[JCI Insight] Scientists generated retinal organoids from iPSCs derived from patients with eyes shut homolog (EYS)-associated retinal dystrophy.
LPA5-Dependent Signaling Regulates Regeneration of the Intestinal Epithelium Following Irradiation
The effects of lysophosphatidic acid (LPA)5 on intestinal stem cells were corroborated by studies using organoids derived from Lgr5-lineage tracking reporter mice with deletion...
Combination of Bazedoxifene with Chemotherapy and SMAC-Mimetics for the Treatment of Colorectal Cancer
Researchers provided evidence that bazedoxifene inhibited tumour growth via direct interaction with the gp130 receptor to suppress IL-6 and IL-11-mediated STAT3 signalling. Additionally, bazedoxifene...
Complex Activity and Short-Term Plasticity of Human Cerebral Organoids Reciprocally Connected with Axons
[Nature Communications] To understand the mechanistic significance of inter-regional projections on development of neural circuits, researchers investigated an in vitro neural tissue model for inter-regional connections, in which two cerebral organoids are connected with a bundle of reciprocally extended axons.
Intestinal Inflammation Marker Calprotectin Regulates Epithelial Intestinal Zinc Metabolism and Proliferation in Mouse Jejunal Organoids
[Biomedicine & Pharmacotherapy] Scientists aimed to characterize the effect of calprotectin on mouse jejunal organoids as a model epithelium, focusing on Zn2+ metabolism and cell proliferation.
Modeling HIV-1 Infection and NeuroHIV in hiPSCs-Derived Cerebral Organoid Cultures
[Journal Of Neurovirology] Researchers generated and characterized several human-induced pluripotent stem cell lines from healthy human donor skin fibroblast cells. hiPSCs were then used for the generation of microglia-containing human cerebral organoids.
Generation of Human Cerebral Organoids with a Structured Outer Subventricular Zone
[Cell Reports] Scientists indicated that increasing the cellular complexity of the organoid microenvironment promoted the emergence of oRG and supported a platform to study the outer radial glia in human pluripotent stem cells-derived brain organoids routinely.
Evaluation of EGFR and COX Pathway Inhibition in Human Colon Organoids of Serrated Polyposis and Other Hereditary Cancer Syndromes
[Familial Cancer] Researchers examined the effects of EGFR and COX pathway inhibition in organoid cultures derived from uninvolved colon and polyps of serrated polyposis syndrome patients. They also compared with organoids representing the hereditary gastrointestinal syndromes, Familial Adenomatous Polyposis and Lynch syndrome.
Organoids are three-dimensional cell cultures that more accurately model cell behavior, organ function, and pathology than traditional two-dimensional cell culture. Organoid News was launched in 2020 to help scientists stay up-to-date with this revolutionary new research system. Use Organoid News to stay current with the latest applications and discoveries using organoids, as well as new reviews, jobs, news, and upcoming events.
