Keep Current with the Latest in Cell Biology Research

COVID-19 Revisiting Inflammatory Pathways of Arthritis

The pattern of pro-inflammatory cytokines induced in COVID-19 has similarities to those targeted in the treatment of rheumatoid arthritis. Several clinical studies are underway that test the effects of inhibiting IL-6, IL-1β or TNF or targeting cytokine signaling via Janus kinase inhibition in the treatment of COVID-19.
[Nature Reviews Rheumatology]
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Mucosal-Associated Invariant T (MAIT) Cells Provide B-Cell Help in Vaccinated and Subsequently SIV-Infected Rhesus Macaques

Scientists investigated MAIT cell dynamics and function in rhesus macaque blood and bronchoalveolar lavage following mucosal adenovirus-SIV recombinant priming, intramuscular SIV envelope boosting and infection following repeated low-dose intravaginal SIV exposures.
[Scientific Reports]
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T-Cell Responses following Natural Influenza Infection or Vaccination in Solid Organ Transplant Recipients

Investigators evaluated the CD4+ and CD8+ responses to influenza A and B infection in a cohort of solid organ transplant patients.
[Scientific Reports]
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Peripherally Induced Brain Tissue–Resident Memory CD8+ T Cells Mediate Protection against CNS Infection

Researchers showed that peripheral infections generated antigen-specific CD8+ memory T cells in the brain that adopted a unique tissue resident memory signature.
[Nature Immunology]
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Factors Associated with Immunosenescence during Early Adulthood in HIV-Infected Patients after Durable Efficient Combination Antiretroviral Therapy

Scientists evaluated which factors independently contributed to immunosenescence in HIV-infected young adults with a very different HIV infection duration, after durable efficient combination antiretroviral therapy.
[Scientific Reports]
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Generation of Knockout Rabbits with X-Linked Severe Combined Immunodeficiency (X-SCID) Using CRISPR/Cas9

X-SCID rabbits presented immunodeficient phenotypes including the loss of T and B cells and hypoplasia of the thymus.
[Scientific Reports]
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The Contribution from Interleukin-27 towards Rheumatoid Inflammation: Insights from Gene Expression

The authors assessed expression of genes encoding the heterodimeric IL-27 cytokine and constituent subunits of the Il-27 receptor in rheumatoid arthritis, including in extra-articular, subcutaneous rheumatoid nodules.
[Genes and Immunity]
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PD-L1 Expression by Dendritic Cells Is a Key Regulator of T-Cell Immunity in Cancer

Investigators demonstrated that dendritic cells represented a critical source of PD-L1, despite being vastly outnumbered by PD-L1+ macrophages.
[Nature Cancer]
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Tet2 and Tet3 in B Cells Are Required to Repress CD86 and Prevent Autoimmunity

The authors report that deficiency of ten–eleven translocation (Tet) DNA demethylase family members Tet2 and Tet3 in B cells led to hyperactivation of B and T cells, autoantibody production and lupus-like disease in mice.
[Nature Immunology]
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Analysis of Ex Vivo Expanded and Activated Clinical-Grade Human NK Cells after Cryopreservation

Scientists evaluated activity of fresh and C/T EA NK cells generated by interleukin (IL)-15, IL-2 and CD137L expansion.
[CytoTherapy]
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Serum Adipokines/Related Inflammatory Factors and Ratios as Predictors of Infrapatellar Fat Pad Volume in Osteoarthritis: Applying Comprehensive Machine Learning Approaches

Scientists used machine learning approaches to predict serum levels of some adipokines/related inflammatory factors and their ratios on knee infrapatellar fat pad volume of osteoarthritis patients.
[Scientific Reports]
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