The pattern of pro-inflammatory cytokines induced in COVID-19 has similarities to those targeted in the treatment of rheumatoid arthritis. Several clinical studies are underway that test the effects of inhibiting IL-6, IL-1β or TNF or targeting cytokine signaling via Janus kinase inhibition in the treatment of COVID-19.
Scientists investigated MAIT cell dynamics and function in rhesus macaque blood and bronchoalveolar lavage following mucosal adenovirus-SIV recombinant priming, intramuscular SIV envelope boosting and infection following repeated low-dose intravaginal SIV exposures.
Researchers showed that peripheral infections generated antigen-specific CD8+ memory T cells in the brain that adopted a unique tissue resident memory signature.
Scientists evaluated which factors independently contributed to immunosenescence in HIV-infected young adults with a very different HIV infection duration, after durable efficient combination antiretroviral therapy.
The authors assessed expression of genes encoding the heterodimeric IL-27 cytokine and constituent subunits of the Il-27 receptor in rheumatoid arthritis, including in extra-articular, subcutaneous rheumatoid nodules.
The authors report that deficiency of ten–eleven translocation (Tet) DNA demethylase family members Tet2 and Tet3 in B cells led to hyperactivation of B and T cells, autoantibody production and lupus-like disease in mice.
Scientists used machine learning approaches to predict serum levels of some adipokines/related inflammatory factors and their ratios on knee infrapatellar fat pad volume of osteoarthritis patients.
