Galera Therapeutics Announces Dosing of First Patient in the Phase I/II GRECO-1 Clinical Trial of GC4711 in Combination with SBRT for Non-Small Cell Lung Cancer

Galera Therapeutics, Inc. announced that the first patient has been dosed in the Phase I/II GRECO-1 clinical trial of GC4711 in combination with stereotactic body radiation therapy in patients with non-small cell lung cancer.
[Galera Therapeutics, Inc.]
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Guanosine Triphosphate Links MYC-Dependent Metabolic and Ribosome Programs in Small Cell Lung Cancer

Investigators demonstrated that primary MYCHigh human small cell lung cancer tumors contain abundant guanosine nucleotides.
[Journal of Clinical Investigation]
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SCLC-CellMiner: A Resource for Small Cell Lung Cancer Cell Line Genomics and Pharmacology Based on Genomic Signatures

The authors demonstrated the reproducibility and stability of data from multiple sources and validate the small cell lung cancer (SCLC) consensus nomenclature on the basis of expression of master transcription factors NEUROD1, ASCL1, POU2F3, and YAP1.
[Cell Reports]
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Lineage Cell Therapeutics and Cancer Research UK Announce Encouraging Preliminary Phase I Study Results with VAC2 for the Treatment of Non-Small Cell Lung Cancer

Lineage Cell Therapeutics, Inc. and Cancer Research UK have announced encouraging preliminary results from an ongoing Phase I clinical study of VAC2 in non-small cell lung cancer (NSCLC). Produced from a pluripotent cell technology using a directed differentiation method, VAC2 has demonstrated remarkably potent induction of immune responses in all patients dosed to date.
[nan]
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PLCγ1 Suppression Promotes the Adaptation of KRAS-Mutant Lung Adenocarcinomas to Hypoxia

Using a lipidomic screen, scientists found that PLCγ1 was suppressed during hypoxia in KRAS-mutant human lung adenocarcinoma cancer cell lines.
[Nature Cell Biology]
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CHIP-Mediated CIB1 Ubiquitination Regulated Epithelial–Mesenchymal Transition and Tumor Metastasis in Lung Adenocarcinoma

The expression levels of CIB1 in lung adenocarcinoma tissues and adjacent normal tissues were examined by immunohistochemistry, and the relationship between CIB1 expression and patient clinicopathological characteristics was analyzed.
[Cell Death & Differentiation]
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Consequences of Zmat3 Loss in c-MYC– and Mutant KRAS-Driven Tumorigenesis

To investigate which oncogenic drivers co-operate with Zmat3 loss to promote neoplastic transformation, researchers utilized Zmat3 knockout mice in models of c-MYC-driven lymphomagenesis and KrasG12D-driven lung adenocarcinoma development.
[Cell Death & Disease]
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Expression of SARS-CoV-2 Entry Factors in Lung Epithelial Stem Cells and Its Potential Implications for COVID-19

Scientists analyzed published RNA-seq datasets and demonstrated that cells of four different lung epithelial stem cell types express SARS-CoV-2 entry factors, including Ace2.
[Scientific Reports]
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Upregulation of KCNQ1OT1 Promotes Resistance to Stereotactic Body Radiotherapy in Lung Adenocarcinoma by Inducing ATG5/ATG12-Mediated Autophagy via miR-372-3p

The differential lncRNAs were screened by microarray assay, then the expression was detected in LUAD tumor tissues and cell lines by qPCR. The influence on radiation response was assessed via in vitro and in vivo assays, and autophagy levels were evaluated by western blot and transmission electron microscopy.
[Cell Death & Disease]
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Importin 13 Promotes NSCLC Progression by Mediating RFPL3 Nuclear Translocation and hTERT Expression Upregulation

The authors identified RFPL3 as a potential import cargo for IPO13, which was found to be overexpressed in NSCLC cells and tissues.
[Cell Death & Disease]
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Aberrant Super-Enhancer Landscape Reveals Core Transcriptional Regulatory Circuitry in Lung Adenocarcinoma

By integrating profiles of H3K27Ac chromatin immunoprecipitation sequencing from normal adult lung and lung adenocarcinoma cell lines, researchers revealed that widespread alterations of the super-enhancer were present during lung carcinogenesis.
[Oncogenesis]
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