MYH9 Is Crucial for Stem Cell-Like Properties in Non-Small Cell Lung Cancer by Activating mTOR Signaling

The authors found that the stemness characteristics of lung cancer cells were significantly enhanced by the overexpression of non-muscle myosin heavy chain 9 (MYH9), and the knockout of MYH9 had the opposite effects.
[Cell Death Discovery]
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M6A RNA Methylation-Mediated RMRP Stability Renders Proliferation and Progression of Non-Small Cell Lung Cancer through Regulating TGFBR1/SMAD2/SMAD3 Pathway

Based on an integrative analysis of The Cancer Genome Atlas database, investigators identified long non-coding RNA-RNA Component of Mitochondrial RNA Processing Endoribonuclease (RMRP) as one of the most highly upregulated lncRNAs that are associated with poor survival in non-small cell lung cancer.
[Cell Death & Differentiation]
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Lixte Biotechnology Announces Collaboration with Netherlands Cancer Institute (Amsterdam) and Oncode Institute (Utrecht) to Identify the Most Promising Drug Combinations for its Lead Clinical Compound, LB-100, for Cancer Treatment

Lixte Biotechnology Holdings, Inc. announced entry into a collaboration with the Netherlands Cancer Institute, Amsterdam, and Oncode Institute, Utrecht to identify the most promising drugs to be combined with LB-100, and potentially LB-100 analogues, to be used to treat a range of cancers, as well as to identify the specific molecular mechanisms underlying the identified combinations.
[Lixte Biotechnology Holdings, Inc.]
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TSSK4 Upregulation in Alveolar Epithelial Type-II Cells Facilitates Pulmonary Fibrosis through HSP90-AKT Signaling Restriction and AT-II Apoptosis

Alveolar epithelial injury is one of the important pathological changes in idiopathic pulmonary interstitial fibrosis, but the regulatory mechanism remains unclear. Scientists reported that alveolar epithelial type-II cells played important roles in pathological process of pulmonary fibrosis.
[Cell Death & Disease]
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Evolution of MET and NRAS Gene Amplification as Acquired Resistance Mechanisms in EGFR Mutant NSCLC

A patient-derived cell line obtained at the time of disease progression was used to identify NRAS gene amplification as an additional driver of drug resistance to combination EGFR/MET therapies.
[npj Precision Oncology]
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In Vitro Impact Preliminary Assessment of Airborne Particulate from Metalworking and Woodworking Industries

3D airway epithelial tissues allowed to mimic exposure conditions in vitro, generated human-relevant toxicology data, and allowed to elucidate the mode of action of pollutants.
[Scientific Reports]
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Protein Co-Expression Network-Based Profiles Revealed from Laser-Microdissected Cancerous Cells of Lung Squamous-Cell Carcinomas

Researchers unveiled disease-related protein networks by proteomic and bioinformatic assessment of laser-microdissected cancerous cells from seven lung squamous cell cancer compared with eight representative lung adenocarcinomas.
[Scientific Reports]
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B.1.617.2 Enters and Fuses Lung Cells with Increased Efficiency and Evades Antibodies Induced by Infection and Vaccination

Investigators showed increased Calu-3 lung cell entry and enhanced cell-to-cell fusion of B.1.617.2, which might contribute to augmented transmissibility and pathogenicity of this variant.
[Thoracic Cancer]
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Comparative Microsomal Proteomics of a Model Lung Cancer Cell Line NCI-H23 Reveals Distinct Differences between Molecular Profiles of 3D and 2D Cultured Cells

To ascertain phenotypical differences between these two distinct culture conditions, scientists carried out a comparative proteomic analysis of a membrane fraction obtained from 3D- and 2D-cultured NSCLC model cell line NCI-H23.
[Oncotarget]
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Ferroptosis: A New Promising Target for Lung Cancer Therapy

The authors summarize the characteristics of ferroptosis from its underlying basis and role in lung cancer and provide possible applications for it in lung cancer therapies.
[Oxidative Medicine and Cellular Longevity]
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Protective Effect of Xiao-Xu-Ming Decoction-Mediated Inhibition of ROS/NLRP3 Axis on Lipopolysaccharide-Induced Acute Lung Injury In Vitro and In Vivo

As a traditional Chinese medicine prescription, Xiao-Xu-Ming decoction (XXMD) could reduce the incidence of lung infection of patients with cerebral infarction. In vitro, human pulmonary alveolar epithelial cells were treated with XXMD and were followed by lipopolysaccharide treatment.
[Evidence-Based Complementary and Alternative Medicine]
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