Scientists presented a detail transcriptome and proteome atlas of the exosomes released by human lung adenocarcinoma stem-like cells.
[NPJ Genomic Medicine]
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Luo, H.-T., Zheng, Y.-Y., Tang, J., Shao, L.-J., Mao, Y.-H., Yang, W., Yang, X.-F., Li, Y., Tian, R.-J., & Li, F.-R. (2021). Dissecting the multi-omics atlas of the exosomes released by human lung adenocarcinoma stem-like cells. Npj Genomic Medicine, 6(1), 1–14. https://doi.org/10.1038/s41525-021-00217-5 Cite
Investigators verified that microRNA-326 (miR-326) repressed the gene expression of immune checkpoint molecules PD-L1 and B7-H3 in lung adenocarcinoma (LUAD). They detected that the expression of miR-326 in LUAD tissue was negatively correlated with PD-L1/B7-H3.
[Cell Death Discovery]
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Shao, L., He, Q., Wang, J., He, F., Lin, S., Wu, L., Gao, Y., Ma, W., Dong, J., Yang, X., & Li, F. (2021). MicroRNA-326 attenuates immune escape and prevents metastasis in lung adenocarcinoma by targeting PD-L1 and B7-H3. Cell Death Discovery, 7(1), 1–10. https://doi.org/10.1038/s41420-021-00527-8 Cite
Scientists comprehensively evaluated the expression of GPC3 in non-small cell lung cancer (NSCLC) and develop a risk-score model for predicting the prognosis of NSCLC.
[BMC Pulmonary Medicine]
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The authors critically analyse the mechanisms of epidermal growth factor receptor expression in non-small cell lung cancer (NSCLC), its relevance to currently approved targeted treatment options, and the complex nature of secondary mutations and intrinsic and acquired resistance patterns in NSCLC.
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Although there have been numerous studies on tumor exosomes, the constituents and functional properties of CSC-derived exosomes are still poorly characterized. The authors presented a detail transcriptome and proteome atlas of the exosomes released by human lung adenocarcinoma stem-like cells.
[npj Genomic Medicine]
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To decrease programmed death-ligand 1 (PD-L1) expression and increase the penetration efficacy of solid tumors, scientists synthesized a novel tumor-microenvironment-sensitive delivery polymer by conjugating hyaluronic acid to polyethyleneimine, with a matrix metalloproteinase-2 -sensitive peptide acting as the linker, for use in delivery of PD-L1–siRNA.
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Wen, J., Qiu, N., Zhu, Z., Bai, P., Hu, M., Qi, W., Liu, Y., Wei, A., & Chen, L. (2021). A size-shrinkable matrix metallopeptidase-2-sensitive delivery nanosystem improves the penetration of human programmed death-ligand 1 siRNA into lung-tumor spheroids. Drug Delivery, 28(1), 1055–1066. https://doi.org/10.1080/10717544.2021.1931560 Cite
Investigators studied effects of recombinant D-dopachrome tautomerase (DDT) on cell proliferation and survival by clonogenic assay and annexin V-PI staining respectively. DDT-induced signaling was investigated by Western blot.
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Song, S., Liu, B., Habibie, H., Bor, J. van den, Smit, M. J., Gosens, R., Wu, X., Brandsma, C.-A., Cool, R. H., Haisma, H. J., Poelarends, G. J., & Melgert, B. N. (2021). D-dopachrome tautomerase contributes to lung epithelial repair via atypical chemokine receptor 3-dependent Akt signaling. EBioMedicine, 68. https://doi.org/10.1016/j.ebiom.2021.103412 Cite
Updated results from the positive PACIFIC Phase III trial showed AstraZeneca’s IMFINZI® (durvalumab) demonstrated a sustained, clinically meaningful overall survival (OS) and progression-free survival (PFS) benefit at five years in patients with unresectable Stage III non-small cell lung cancer (NSCLC) who had not progressed following concurrent chemoradiation therapy (CRT).
[AstraZeneca, Inc. (BusinessWire, Inc.)]
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MigVax Ltd., a startup company developing an oral subunit vaccine against COVID-19, today announced promising results from preclinical tests that demonstrated the effectivity of its MigVax-101 subunit oral vaccine as a booster for previously vaccinated persons.
[MigVax Ltd. (BusinessWire, Inc.)]
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Researchers showed that metformin inhibited NLRP3 inflammasome activation and interleukin (IL)-1β production in cultured and alveolar macrophages along with inflammasome-independent IL-6 secretion, thus attenuating lipopolysaccharide- and SARS-CoV-2-induced Acute respiratory distress syndrome.
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Xian, H., Liu, Y., Nilsson, A. R., Gatchalian, R., Crother, T. R., Tourtellotte, W. G., Zhang, Y., Aleman-Muench, G. R., Lewis, G., Chen, W., Kang, S., Luevanos, M., Trudler, D., Lipton, S. A., Soroosh, P., Teijaro, J., Torre, J. C. de la, Arditi, M., Karin, M., & Sanchez-Lopez, E. (2021). Metformin inhibition of mitochondrial ATP and DNA synthesis abrogates NLRP3 inflammasome activation and pulmonary inflammation. Immunity, 0(0). https://doi.org/10.1016/j.immuni.2021.05.004 Cite
Researchers revealed that m6A modification was up-regulated in bleomycin induced pulmonary fibrosis mice model, FMT-derived myofibroblasts and idiopathic pulmonary fibrosis patient lung samples.
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Zhang, J., Huang, P., Wang, D., Yang, W., Lu, J., Zhu, Y., Meng, X., Wu, X., Lin, Q., Lv, H., Xie, H., & Wang, R. (2021). m6A modification regulates lung fibroblast-to-myofibroblast transition through modulating KCNH6 mRNA translation. Molecular Therapy, 0(0). https://doi.org/10.1016/j.ymthe.2021.06.008 Cite