Category Archives: Pulmonary Cell

Pulmonary Cell News is an online publication and email newsletter dedicated to the topics of respiratory disease, lung cancer, and pulmonary cells.
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Spurred by advances in the modeling of the airway epithelium, Pulmonary Cell News was launched in 2012 to help scientists stay at the forefront of cutting edge research. Every week, our editors hand-select the most recent, top scientific journal articles on the topics of pulmonary cells, lung cancers, and respiratory diseases such as COPD and asthma. We also highlight current job postings and upcoming events to keep the global research community connected!

Dissecting the Multi-Omics Atlas of the Exosomes Released by Human Lung Adenocarcinoma Stem-Like Cells

Scientists presented a detail transcriptome and proteome atlas of the exosomes released by human lung adenocarcinoma stem-like cells.
[NPJ Genomic Medicine]
Luo, H.-T., Zheng, Y.-Y., Tang, J., Shao, L.-J., Mao, Y.-H., Yang, W., Yang, X.-F., Li, Y., Tian, R.-J., & Li, F.-R. (2021). Dissecting the multi-omics atlas of the exosomes released by human lung adenocarcinoma stem-like cells. Npj Genomic Medicine, 6(1), 1–14. https://doi.org/10.1038/s41525-021-00217-5 Cite
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MicroRNA-326 Attenuates Immune Escape and Prevents Metastasis in Lung Adenocarcinoma by Targeting PD-L1 and B7-H3

Investigators verified that microRNA-326 (miR-326) repressed the gene expression of immune checkpoint molecules PD-L1 and B7-H3 in lung adenocarcinoma (LUAD). They detected that the expression of miR-326 in LUAD tissue was negatively correlated with PD-L1/B7-H3.
[Cell Death Discovery]
Shao, L., He, Q., Wang, J., He, F., Lin, S., Wu, L., Gao, Y., Ma, W., Dong, J., Yang, X., & Li, F. (2021). MicroRNA-326 attenuates immune escape and prevents metastasis in lung adenocarcinoma by targeting PD-L1 and B7-H3. Cell Death Discovery, 7(1), 1–10. https://doi.org/10.1038/s41420-021-00527-8 Cite
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GPC3 Affects the Prognosis of Lung Adenocarcinoma and Lung Squamous Cell Carcinoma

Scientists comprehensively evaluated the expression of GPC3 in non-small cell lung cancer (NSCLC) and develop a risk-score model for predicting the prognosis of NSCLC.
[BMC Pulmonary Medicine]
Ning, J., Jiang, S., Li, X., Wang, Y., Deng, X., Zhang, Z., He, L., Wang, D., & Jiang, Y. (2021). GPC3 affects the prognosis of lung adenocarcinoma and lung squamous cell carcinoma. BMC Pulmonary Medicine, 21(1), 199. https://doi.org/10.1186/s12890-021-01549-9 Cite
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Epidermal Growth Factor Receptor Expression and Resistance Patterns to Targeted Therapy in Non-small Cell Lung Cancer: A Review

The authors critically analyse the mechanisms of epidermal growth factor receptor expression in non-small cell lung cancer (NSCLC), its relevance to currently approved targeted treatment options, and the complex nature of secondary mutations and intrinsic and acquired resistance patterns in NSCLC.
[Cells]
Karlsen, E.-A., Kahler, S., Tefay, J., Joseph, S. R., & Simpson, F. (2021). Epidermal Growth Factor Receptor Expression and Resistance Patterns to Targeted Therapy in Non-Small Cell Lung Cancer: A Review. Cells, 10(5), 1206. https://doi.org/10.3390/cells10051206 Cite
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Dissecting the Multi-Omics Atlas of the Exosomes Released by Human Lung Adenocarcinoma Stem-Like Cells

Although there have been numerous studies on tumor exosomes, the constituents and functional properties of CSC-derived exosomes are still poorly characterized. The authors presented a detail transcriptome and proteome atlas of the exosomes released by human lung adenocarcinoma stem-like cells.
[npj Genomic Medicine]
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A Size-Shrinkable Matrix Metallopeptidase-2-Sensitive Delivery Nanosystem Improves the Penetration of Human Programmed Death-Ligand 1 siRNA into Lung-Tumor Spheroids

To decrease programmed death-ligand 1 (PD-L1) expression and increase the penetration efficacy of solid tumors, scientists synthesized a novel tumor-microenvironment-sensitive delivery polymer by conjugating hyaluronic acid to polyethyleneimine, with a matrix metalloproteinase-2 -sensitive peptide acting as the linker, for use in delivery of PD-L1–siRNA.
[Drug Delivery]
Wen, J., Qiu, N., Zhu, Z., Bai, P., Hu, M., Qi, W., Liu, Y., Wei, A., & Chen, L. (2021). A size-shrinkable matrix metallopeptidase-2-sensitive delivery nanosystem improves the penetration of human programmed death-ligand 1 siRNA into lung-tumor spheroids. Drug Delivery, 28(1), 1055–1066. https://doi.org/10.1080/10717544.2021.1931560 Cite
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D-Dopachrome Tautomerase Contributes to Lung Epithelial Repair via Atypical Chemokine Receptor 3-Dependent Akt Signaling

Investigators studied effects of recombinant D-dopachrome tautomerase (DDT) on cell proliferation and survival by clonogenic assay and annexin V-PI staining respectively. DDT-induced signaling was investigated by Western blot.
[Ebiomedicine]
Song, S., Liu, B., Habibie, H., Bor, J. van den, Smit, M. J., Gosens, R., Wu, X., Brandsma, C.-A., Cool, R. H., Haisma, H. J., Poelarends, G. J., & Melgert, B. N. (2021). D-dopachrome tautomerase contributes to lung epithelial repair via atypical chemokine receptor 3-dependent Akt signaling. EBioMedicine, 68. https://doi.org/10.1016/j.ebiom.2021.103412 Cite
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IMFINZI Demonstrated Unprecedented Survival in Unresectable Stage III Lung Cancer with 43% of Patients Surviving Five Years

Updated results from the positive PACIFIC Phase III trial showed AstraZeneca’s IMFINZI® (durvalumab) demonstrated a sustained, clinically meaningful overall survival (OS) and progression-free survival (PFS) benefit at five years in patients with unresectable Stage III non-small cell lung cancer (NSCLC) who had not progressed following concurrent chemoradiation therapy (CRT).
[AstraZeneca, Inc. (BusinessWire, Inc.)]
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MigVax’s Subunit Oral COVID-19 Vaccine Preclinical Trial Demonstrates Effectivity as a Booster

MigVax Ltd., a startup company developing an oral subunit vaccine against COVID-19, today announced promising results from preclinical tests that demonstrated the effectivity of its MigVax-101 subunit oral vaccine as a booster for previously vaccinated persons.
[MigVax Ltd. (BusinessWire, Inc.)]
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Metformin Inhibition of Mitochondrial ATP and DNA Synthesis Abrogates NLRP3 Inflammasome Activation and Pulmonary Inflammation

Researchers showed that metformin inhibited NLRP3 inflammasome activation and interleukin (IL)-1β production in cultured and alveolar macrophages along with inflammasome-independent IL-6 secretion, thus attenuating lipopolysaccharide- and SARS-CoV-2-induced Acute respiratory distress syndrome.
[Immunity]
Xian, H., Liu, Y., Nilsson, A. R., Gatchalian, R., Crother, T. R., Tourtellotte, W. G., Zhang, Y., Aleman-Muench, G. R., Lewis, G., Chen, W., Kang, S., Luevanos, M., Trudler, D., Lipton, S. A., Soroosh, P., Teijaro, J., Torre, J. C. de la, Arditi, M., Karin, M., & Sanchez-Lopez, E. (2021). Metformin inhibition of mitochondrial ATP and DNA synthesis abrogates NLRP3 inflammasome activation and pulmonary inflammation. Immunity, 0(0). https://doi.org/10.1016/j.immuni.2021.05.004 Cite
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m6A Modification Regulates Lung Fibroblast-to-Myofibroblast Transition through Modulating KCNH6 mRNA Translation

Researchers revealed that m6A modification was up-regulated in bleomycin induced pulmonary fibrosis mice model, FMT-derived myofibroblasts and idiopathic pulmonary fibrosis patient lung samples.
[Molecular Therapy]
Zhang, J., Huang, P., Wang, D., Yang, W., Lu, J., Zhu, Y., Meng, X., Wu, X., Lin, Q., Lv, H., Xie, H., & Wang, R. (2021). m6A modification regulates lung fibroblast-to-myofibroblast transition through modulating KCNH6 mRNA translation. Molecular Therapy, 0(0). https://doi.org/10.1016/j.ymthe.2021.06.008 Cite
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