Development and Validation of a Hypoxia-Associated Signature for Lung Adenocarcinoma

Researchers developed a lung adenocarcinoma (LUAD) hypoxia-related gene expression signature. RNAseq was used to identify genes significantly differentially expressed under hypoxia in four LUAD cell lines.
[Scientific Reports]
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Characterization of the COPD Alveolar Niche Using Single-Cell RNA Sequencing

The authors analyzed single-cell RNA sequencing profiles of explanted lung tissue from subjects with advanced COPD or control lungs and identified a subpopulation of alveolar epithelial type II cells with transcriptional evidence for aberrant cellular metabolism and reduced cellular stress tolerance in COPD.
[Nature Communications]
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Targeting ADRB2 Enhances Sensitivity of Non-Small Cell Lung Cancer to VEGFR2 Tyrosine Kinase Inhibitors

Investigators suggested that treatment with vascular endothelial growth factor receptor 2 (VEGFR2)-tyrosine kinase inhibitors upregulated ADRB2 expression in NSCLC cells.
[Cell Death Discovery]
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Nogo-B Promotes Invasion and Metastasis of Nasopharyngeal Carcinoma via RhoA-SRF-MRTFA Pathway

Scientists found that higher expression of neurite outgrowth inhibitor B (Nogo-B) was detected in nasopharyngeal carcinoma (NPC) cells and tissues. Higher expression of Nogo-B was statistically relevant to N stage, M stage, and poor prognosis in NPC patients.
[Cell Death & Disease]
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SARS-CoV-2 Infection Triggers Paracrine Senescence and Leads to a Sustained Senescence-Associated Inflammatory Response

In cultured human cells or bronchial organoids, SASR-CoV-2 infection-induced senescent cells expressed high levels of a series of inflammatory factors known as senescence-associated secretory phenotypes 4 in a sustained manner, even after SARS-CoV-2 was no longer detectable.
[Nature Aging]
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ArkBio Announces Completion of Patient Enrollment and Dosing in AIRFLO, a Phase III Registration Trial of Ziresovir for Treatment of Respiratory Syncytial Virus Infection

Ark Biopharmaceutical Co., Ltd. announced the completion of patient enrollment and dosing of ziresovir for the treatment of respiratory syncytial virus infection in a Phase III registration clinical trial.
[Ark Biopharmaceutical Co., Ltd.]
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Biomimetic Human Lung-on-a-Chip with Colorful Displaying Microphysiological Breath

Scientists presented a novel biomimetic 3D microphysiological lung-on-a-chip system with breathing visuality.
[Advanced Materials]
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Estrogen Receptor Beta Promotes Lung Cancer Invasion via Increasing CXCR4 Expression

Scientists found that ERβ could promote NSCLC cell invasion via increasing the circular RNA (circRNA), circ-TMX4, expression via directly binding to the 5′ promoter region of its host gene TMX4.
[Cell Death & Disease]
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RBL2/DREAM-Mediated Repression of the Aurora Kinase A/B Pathway Determines Therapy Responsiveness and Outcome in p53 WT NSCLC

Researchers found heightened expression of RB-family (RBL) 2 and reduced expression of AURKA/B pathway genes was associated with improved outcomes in p53 wild-type but not p53 mutant NSCLC patients.
[Scientific Reports]
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CDK4/6-USP51 Axis Regulates Lung Adenocarcinoma Metastasis through ZEB1

Scientists demonstrated that USP51 was overexpressed in metastatic human lung adenocarcinoma and patients with high USP51 expression in their tumors have shorter overall survival than those with low expression of USP51.
[Cancer Gene Therapy]
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Extracellular Vesicles Released by Non-Small Cell Lung Cancer Cells Drive Invasion and Permeability in Non-tumorigenic Lung Epithelial Cells

Secretion analysis revealed that cancer cells vary in their secretion level, with some cell lines having relatively low secretion rates.
[Scientific Reports]
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