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Pulmonary Cell News
Pulmonary Cell News is an online resource dedicated to the topics of respiratory disease, lung cancer, and pulmonary cells.
Co-Development of Mesoderm and Endoderm Enables Organotypic Vascularization in Lung and Gut Organoids
[Cell] Scientists co-differentiated mesoderm and endoderm within the same spheroid to vascularize lung and intestinal organoids from iPSCs.
SLC34A2 Inhibits Tumorigenesis and Progression via Upregulating LRRK2/TTF-1/SELENBP1 Axis in Lung Adenocarcinoma
[Cancer Gene Therapy] Investigators discovered that the protein expression of Napi2b (SLC34A2), SELENBP1, TTF-1, and LRRK2 were all located in human alveolar type II epithelial cells of adjacent non-tumor tissues.
SREBP-2 Promotes Cancer Progression through the Mevalonate-Akt Pathway in Non-Small Cell Lung Cancer
[Scientific Reports] The prognostic significance of sterol regulatory element-binding protein-2 (SREBP-2) in NSCLC patients, and the functional roles of SREBP-2 in NSCLC proliferation, migration, and invasion was examined.
Bio-Engineered microRNA-7 Effectively Interferes with the Akt3/P53 Axis to Suppress Human Non-Small Cell Lung Cancer
[Cancer Cell International] The authors screened p53-associated microRNAs that were differentially expressed in NSCLC and benign tissues by bioinformatic analysis.
Spatial Phenotyping of Human Bronchial Airways in Obstructive Lung Disease
[Respiratory Research] Utilizing spatial phenotyping, researchers interrogated the features and cellular landscape of lungs from non-asthmatics, asthmatics, and COPD in formalin-fixed paraffin-embedded samples by developing a 10-plex antibody panel for the Akoya PhenoCycler®-Fusion system.
DATROWAY® Approved in the U.S. as First TROP2 Directed Therapy for Patients with Previously Treated Advanced EGFR-Mutated Non-Small Cell Lung Cancer
[Daiichi-Sankyo] DATROWAY® has been approved in the U.S. for the treatment of adult patients with locally advanced or metastatic EGFR-mutated NSCLC who have received prior EGFR-directed therapy and platinum-based chemotherapy.
EGFR TKIs Suppress MUC1 Glycosylation through the PI3K/AKT/SP1/C1GALT1 Pathway to Enhance TnMUC1 CAR-T Efficacy in EGFR-Mutant NSCLC
[Cell Reports Medicine] Investigators showed that epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) enhance the efficacy of TnMUC1 CAR-T cell therapy in EGFR-mutant NSCLC, both in vitro and in vivo.
Serum Amyloid A3 Aggravates Bleomycin-Induced Pulmonary Fibrosis through KrüPpel-Like Factor 6-Dependent Interlukin-36α Expression
[Acta Pharmacologica Sinica] Scientists found that the expression of endogenous serum amyloid A3 was significantly induced in mice with bleomycin-induced fibrosis.
Direct Reprogramming of Mouse Fibroblasts into Self-Renewable Alveolar Epithelial-Like Cells
[npj Regenerative Medicine] The authors reported the direct reprogramming of mouse tail tips and embryonic fibroblasts into induced pulmonary alveolar epithelial-like cells using four transcription factor-coding genes and three-dimensional culture.
Orforglipron, an Oral Small-Molecule GLP-1 Receptor Agonist, in Early Type 2 Diabetes
[New England Journal of Medicine] In this Phase III, double-blind, placebo-controlled trial, we randomly assigned participants in a 1:1:1:1 ratio to receive orforglipron at one of three doses or placebo once daily for 40 weeks.
Stem Cell–Derived, Fully Differentiated Islets for Type 1 Diabetes
[New England Journal of Medicine] Investigators conducted a Phase I–II study of zimislecel in persons with type 1 diabetes. In part A, participants received a half dose of zimislecel as a single infusion into the portal vein, with an option for a second half dose within two years. In parts B and C, participants received a full dose of zimislecel as a single infusion.
Glucose Metabolism and Regulation in Establishing Human Stem Cell-Derived β Cell Maturation
[Cell Reports] Scientists summarize the updated understanding of glucose metabolism in mature β and stem cell-derived β (SC-β) cells, highlighting a potential metabolic defect underlying SC-β immaturity.
Spurred by advances in the modeling of the airway epithelium, Pulmonary Cell News was launched in 2012 to help scientists stay at the forefront of cutting edge research. Every week, our editors hand-select the most recent, top scientific journal articles on the topics of pulmonary cells, lung cancers, and respiratory diseases such as COPD and asthma. We also highlight current job postings and upcoming events to keep the global research community connected!
