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Pulmonary Cell News
Pulmonary Cell News is an online resource dedicated to the topics of respiratory disease, lung cancer, and pulmonary cells.
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Zanubrutinib Mitigates Pulmonary Fibrosis in Aged Mice by Targeting the Wnt/β-catenin Signaling Pathway
[Biochemical Pharmacology] The authors discussed the potential effects and mechanisms of Zanubrutinib on aging lung fibrosis in vivo and in vitro.
Alveolar Epithelial Cell-Derived Exosomes Regulate Autophagy through miR-450b-5p/HDAC7 to Improve Pulmonary Fibrosis
[FASEB Journal] A cell fibrosis model was constructed using TGF-β, and a mouse fibrosis model was constructed with bleomycin, treated with alveolar epithelial cell-derived exosomes, which was interfered with by treatment with a miR-450b-5p inhibitor.
Luteoloside Alleviates Bleomycin-Induced Pulmonary Fibrosis in Mice via SIRT1-Mediated Protective Effect against Alveolar Epithelial Cell Senescence
[Scientific Reports] The authors explored the anti-senescence and anti-fibrotic effects of luteoloside in experimental pulmonary fibrosis and investigate its underlying molecular mechanisms.
RAS-GTP Inhibition Overcomes Acquired Resistance to KRASG12C Inhibitors Mediated by Oncogenic and Wildtype RAS Activation in Non-Small Cell Lung Cancer
[Cancer Research] Scientists generated resistant cell lines and patient-derived xenograft models to KRASG12C(OFF) and RAS(ON) G12C-selective inhibitors and interrogated resistance mechanisms.
Lamin A/C Loss Promotes R-Loop-Mediated Genomic Instability and Poor Survival in Small-Cell Lung Cancer
[Proceedings of The National Academy of Sciences of The United States of America] Researchers showed that lamin A/C loss disrupts nuclear pore complex organization and impairs RNA export, leading to R-loop accumulation, replication stress, and genome instability.
Genome-Wide Association, Single-Cell, and Spatial Transcriptomics Analyses Reveal the Role of the STK24-Expressing Positive Cells in LUAD Progression, and the Tumor Microenvironment, Identifying STK24...
[Journal of Translational Medicine] Scientists integrated GWAS data from FinnGen, IEU OpenGWAS, and GWAS Catalog with single-cell and spatial transcriptomics from GEO to investigate LUAD genetics and pathology.
Therapeutic Approach to COPD by Targeting Pulmonary Associated Cell Signaling Pathways
[Life Sciences] Investigators explore the mechanistic involvement of key signaling pathways in COPD progression, focusing on their impact on inflammation, oxidative stress, airway remodeling, and fibrosis.
Lung Association Steps Up with $22 Million in Research Funding as Federal Support for Science Wavers
[American Lung Association] The American Lung Association Research Institute announced it has invested $22 million in new research grants, clinical research and strategic partnerships to advance the understanding, diagnosis, treatment, and prevention of lung disease.
MYSM1 Promotes Lung Adenocarcinoma Progression via TRAF2/3-Mediated Activation of MAPK and Non-Canonical NF-κB Pathways
[npj Precision Oncology] Functional assays demonstrated that MYSM1 promotes LUAD cell proliferation and migration in vitro and in vivo.
Hypoxia-Induced Exosomal LUCAT1 Promotes Osimertinib Resistance in Lung Adenocarcinoma by Stabilizing c-MET
[Cell Death & Disease] Researchers elucidated the function and mechanisms of hypoxia-induced exosomes in promoting osimertinib resistance in LUAD, with the goal of identifying potential diagnostic biomarkers and therapeutic targets.
Particulate Matter Exposure-Induced Cholesterol Metabolism Dysregulation in Lung Epithelial Cells
[Toxicology in Vitro] RNA sequencing was employed to explore the molecular mechanisms of micrometer-sized particulate matters obtained from air near the Yellow River on mink lung epithelial cells.
p53 Drives Lung Cancer Regression through a TSC2/TFEB-Dependent Senescence Program
[Cancer Discovery] Scientists used mouse and human models to deconstruct the transcriptional programs and sequelae underlying robust therapeutic responses in LUAD.
Spurred by advances in the modeling of the airway epithelium, Pulmonary Cell News was launched in 2012 to help scientists stay at the forefront of cutting edge research. Every week, our editors hand-select the most recent, top scientific journal articles on the topics of pulmonary cells, lung cancers, and respiratory diseases such as COPD and asthma. We also highlight current job postings and upcoming events to keep the global research community connected!
