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Pulmonary Cell News
Pulmonary Cell News is an online resource dedicated to the topics of respiratory disease, lung cancer, and pulmonary cells.
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Autocrine SFRP2 (Secreted Frizzled Related Protein 2) Enhances Lung Myofibroblast Fibrogenic Activity by Suppressing PINK1-Mediated Mitophagy Initiation
[Autophagy] Using single-cell RNA sequencing, researchers identified SFRP2 as a critical mediator of profibrotic myofibroblasts in idiopathic pulmonary fibrosis lungs.
E2A Selectively Regulates TGF-β-Induced Apoptosis in KRAS-Mutant Non-Small Cell Lung Cancer
[Molecular Oncology] Investigators identified the transcription factor E2A as a critical mediator of resistance to transforming growth factor-β (TGF-β)-induced apoptosis in mutant KRAS–driven NSCLC.
TNIK Overexpression Is Sufficient for Chemoradiation Resistance in Limited-Stage Small Cell Lung Cancer
[Molecular Cancer Therapeutics] Researchers used patient-derived xenografts to model small cell lung cancer chemoradiation resistance and identified chemoradiation resistance candidate genes using RNA sequencing.
The Combined Inhibitory Effect of Butaselen and Decitabine against Lung Cancer Cells
[Scientific Reports] Scientists investigated the combined effects of the thioredoxin reductase inhibitor butaselen and decitabine on lung cancer cells in vitro.
TRIM3 Suppresses Tumor Progression in Non-Small-Cell Lung Cancer by Promoting PD-L1 Ubiquitination and Degradation
[Annals of Surgical Oncology] The authors investigated TRIM3 expression and its role in the immune microenvironment of NSCLC. TRIM3 levels in NSCLC tissues and cells were detected by reverse transcriptase quantitative polymerase chain reaction.
Trigonelline Suppresses the Tumor Progression via STAT2 Signalling Pathway in Non-Small Cell Lung Carcinoma
[Medical Oncology] Researchers investigated its therapeutic efficacy against A549 lung cancer cells and elucidates the underlying molecular mechanisms.
Targeting the Epithelium in Pulmonary Fibrosis
[European Respiratory Review] Scientists epithelial populations, identified and validated through cutting-edge technologies, may provide targets for the next wave of therapeutics for patients with idiopathic pulmonary fibrosis.
MicroRNA-Regulated Signaling and Tumor Microenvironment Modulation in Lung Cancer: Mechanistic Insights and Translational Opportunities
[Cancer Cell International] By providing insights into the molecular functions of miRNAs, investigators elucidate the promising prospects of miRNAs as biomarkers for early diagnosis and targets for novel therapeutic strategies in lung cancer.
Hydrogel-Based Airway-on-Tube With Perfusable Endothelial Lumen and Outward Epithelialization
[Advanced Materials] Investigators introduced an airway-on-tube that integrates an engineered ECM hydrogel, tuned to match lung tissue stiffness, with a tubular melt electrowritten scaffold.
Novocure Announces Optune Lua® Receives Reimbursement Approval in Japan for the Treatment of Non-Small Cell Lung Cancer
[Novocure] Novocure announced that Japan’s Ministry of Health, Labour and Welfare approved reimbursement for Optune Lua® through the country’s National Health Insurance coverage.
Clu Transitional Alveolar Epithelial Cells Promote Lung Injury Repair and Fibrosis Progression
[British Journal of Pharmacology] Researchers investigated an intermediate subpopulation of alveolar epithelial cells, termed “Regeneration Alveolar Epithelial cells“, which reached a peak 14 days post-injury.
Targeting the Lipid Metabolism Proteins FASN and GPAM in Alveolar Type II Cells Decreases Lung Metastasis
[Cancer Discovery] Investigators discovered that breast cancer-derived lung metastases stimulate the proliferation of alveolar type II cells in their vicinity and reprogram them into lipid feeder cells in mice and patients using spatial analysis.
Spurred by advances in the modeling of the airway epithelium, Pulmonary Cell News was launched in 2012 to help scientists stay at the forefront of cutting edge research. Every week, our editors hand-select the most recent, top scientific journal articles on the topics of pulmonary cells, lung cancers, and respiratory diseases such as COPD and asthma. We also highlight current job postings and upcoming events to keep the global research community connected!
