Scientists used total HDL and HDL subfractions isolated from human plasma, to test insulin secretion under different glucose concentrations as well as insulin content and cholesterol efflux in the insulinoma MIN-6 cell line.
[Journal of Endocrinological Investigation]
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Ochoa-Guzmán, A., Guillén-Quintero, D., Muñoz-Hernández, L., García, A., Díaz-Díaz, E., Pérez-Méndez, O., Rodríguez-Guillén, R., Mitre-Aguilar, I. B., Zentella-Dehesa, A., Aguilar-Salinas, C. A., & Tusié-Luna, M. T. (2021). The influence of high-density lipoprotein (HDL) and HDL subfractions on insulin secretion and cholesterol efflux in pancreatic derived β-cells. Journal of Endocrinological Investigation. https://doi.org/10.1007/s40618-021-01504-9 Cite
Investigators present the physiological roles, pharmacology and clinical studies of lipid receptors and discuss the challenges associated with their clinical development for the treatment of type 2 diabetes mellitus.
[Nature Reviews Endocrinology]
Researchers suggested that microdose lithium conferred a protective effect on islet β-cells via targeting the GSK3β-regulated Nrf2 antioxidant response and thereby ameliorated type 1 diabetes mellitus and its related kidney impairment.
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The authors showed that La-related protein 1 (LARP1) was the most expressed LARP in mouse islets and human β-cells, being two–four-fold more abundant than LARP1B, a member of the family that also interacts with rapamycin complex 1.
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Scientists showed that shRNA-mediated SIX2 or SIX3 suppression in human pancreatic adult islets impaired insulin secretion.
[Genes & Development]
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Researchers showed that a recently identified autophagy enhancer (MSL-7) reduces human IAPP oligomer accumulation in human iPSC-derived β-cells and diminishes oligomer-mediated apoptosis of β-cells.
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Kim, J., Park, K., Kim, M. J., Lim, H., Kim, K. H., Kim, S.-W., Lee, E.-S., Kim, H. (Henry), Kim, S. J., Hur, K. Y., Kim, J. H., Ahn, J. H., Yoon, K.-H., Kim, J.-W., & Lee, M.-S. (2021). An autophagy enhancer ameliorates diabetes of human IAPP -transgenic mice through clearance of amyloidogenic oligomer. Nature Communications, 12(1), 183. https://doi.org/10.1038/s41467-020-20454-z Cite
Adocia announced it has developed a hydrogel scaffold that hosts and protects pancreatic β cells for replacement of the missing cells of people with type 1 diabetes.
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Scientists developed a stable β-cell line that retains the characteristics of mature β-cells.
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Establishment of a long-term stable β-cell line and its application to analyze the effect of Gcg expression on insulin secretion | Scientific Reports. (n.d.). Retrieved January 12, 2021, from https://www.nature.com/articles/s41598-020-79992-7 Cite
The authors performed miRNA-seq analysis from isolated Interstitial cells of Cajal (ICCs) in diabetic mice and plasma from patients with idiopathic and diabetic gastroparesis.
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Scientists report a key β cell-macrophage crosstalk pathway mediated by the miRNA-29-TNF-receptor-associated factor 3 (TRAF3) axis.
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Sun, Y., Zhou, Y., Shi, Y., Zhang, Y., Liu, K., Liang, R., Sun, P., Chang, X., Tang, W., Zhang, Y., Li, J., Wang, S., Zhu, Y., & Han, X. (2021). Expression of miRNA-29 in Pancreatic β Cells Promotes Inflammation and Diabetes via TRAF3. Cell Reports, 34(1). https://doi.org/10.1016/j.celrep.2020.108576 Cite
Scientists discuss the different cell types used to prepare heterocellular organoids for islet transplantation and their contribution to the organoids design.
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Recent advances in the design of implantable insulin secreting heterocellular islet organoids - ScienceDirect. (n.d.). Retrieved January 5, 2021, from https://www.sciencedirect.com/science/article/abs/pii/S0142961220308747 Cite