IL-17F possessed similar pathogenic activities to IL-17A in mouse β-cell lines and islets and was likely to be a type 17 associated pathogenic factor in type 1 diabetes.
Researchers evaluated the potential beneficial effects of DGAT1 inhibitors on pancreatic β-cells, and further verified their antidiabetic effects in db/db mice.
[Acta Pharmacologica Sinica]
To further evaluate the role of UBASH3A in type 1 diabetes, scientists targeted Ubash3a in NOD mice using zinc-finger nuclease mediated mutagenesis.
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Investigators found that tectorigenin could suppress induced apoptosis and improved the viability of β-cells under glucotoxicity and lipotoxicity by activation of ERK and reduction of reactive oxygen species and endoplasmic reticulum stress.
[Journal of Biological Chemistry]
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Yao, X., Li, K., Liang, C., Zhou, Z., Wang, J., Wang, S., Liu, L., Yu, C.-L., Song, Z.-B., Bao, Y.-L., Zheng, L.-H., Sun, Y., Wang, G., Huang, Y., Yi, J., Sun, L., & Li, Y. (2020). Tectorigenin enhances PDX1 expression and protects pancreatic β-cells by activating ERK and reducing ER stress. Journal of Biological Chemistry, jbc.RA120.012849. https://doi.org/10.1074/jbc.RA120.012849 Cite
The authors review the biological sources and functions of exosomes, as well as intercellular crosstalk between β-cells and other cells that is involved in β-cell failure and regeneration.
[Archives of Physiology and Biochemistry]
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Cross talk between exosomes and pancreatic β-cells in diabetes: Archives of Physiology and Biochemistry: Vol 0, No 0. (n.d.). Retrieved July 14, 2020, from https://www.tandfonline.com/doi/abs/10.1080/13813455.2020.1760303 Cite
Investigators describe an in vitro platform that modeled features of human type 1 diabetes using stress-induced patient-derived endocrine cells and autologous immune cells.
To examine the interaction of immune cells and their cellular targets in type 1 diabetes, scientists differentiated human induced pluripotent stem cells into pancreatic endocrine cells, including β cells.
The authors review recent advances in the engineering of stem cell-derived β (SC-β) cells to understand and improve SC-β cell differentiation and functional maturation, particularly new differentiation strategies achieving dynamic glucose-responsive insulin secretion with rapid correction to normoglycemia when transplanted into diabetic mice.
[Frontiers in Bioengineering and Biotechnology]
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