IL-17F Induces Inflammation, Dysfunction and Cell Death in Mouse Islets

IL-17F possessed similar pathogenic activities to IL-17A in mouse β-cell lines and islets and was likely to be a type 17 associated pathogenic factor in type 1 diabetes.
[Scientific Reports]
Catterall, T., Fynch, S., Kay, T. W. H., Thomas, H. E., & Sutherland, A. P. R. (2020). IL-17F induces inflammation, dysfunction and cell death in mouse islets. Scientific Reports, 10(1), 13077. https://doi.org/10.1038/s41598-020-69805-2 Cite
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DGAT1 Inhibitors Protect Pancreatic β-Cells from Palmitic Acid-Induced Apoptosis

Researchers evaluated the potential beneficial effects of DGAT1 inhibitors on pancreatic β-cells, and further verified their antidiabetic effects in db/db mice.
[Acta Pharmacologica Sinica]
Huang, J., Guo, B., Wang, G., Zeng, L., Hu, Y., Wang, T., & Wang, H. (2020). DGAT1 inhibitors protect pancreatic β-cells from palmitic acid-induced apoptosis. Acta Pharmacologica Sinica, 1–8. https://doi.org/10.1038/s41401-020-0482-7 Cite
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UBASH3A Deficiency Accelerates Type 1 Diabetes Development and Enhances Salivary Gland Inflammation in NOD Mice

To further evaluate the role of UBASH3A in type 1 diabetes, scientists targeted Ubash3a in NOD mice using zinc-finger nuclease mediated mutagenesis.
[Scientific Reports]
Chen, Y.-G., Ciecko, A. E., Khaja, S., Grzybowski, M., Geurts, A. M., & Lieberman, S. M. (2020). UBASH3A deficiency accelerates type 1 diabetes development and enhances salivary gland inflammation in NOD mice. Scientific Reports, 10(1), 12019. https://doi.org/10.1038/s41598-020-68956-6 Cite
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Tectorigenin Enhances PDX1 Expression and Protects Pancreatic β-Cells by Activating ERK and Reducing ER Stress

Investigators found that tectorigenin could suppress induced apoptosis and improved the viability of β-cells under glucotoxicity and lipotoxicity by activation of ERK and reduction of reactive oxygen species and endoplasmic reticulum stress.
[Journal of Biological Chemistry]
Yao, X., Li, K., Liang, C., Zhou, Z., Wang, J., Wang, S., Liu, L., Yu, C.-L., Song, Z.-B., Bao, Y.-L., Zheng, L.-H., Sun, Y., Wang, G., Huang, Y., Yi, J., Sun, L., & Li, Y. (2020). Tectorigenin enhances PDX1 expression and protects pancreatic β-cells by activating ERK and reducing ER stress. Journal of Biological Chemistry, jbc.RA120.012849. https://doi.org/10.1074/jbc.RA120.012849 Cite
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Cross Talk between Exosomes and Pancreatic β-Cells in Diabetes

The authors review the biological sources and functions of exosomes, as well as intercellular crosstalk between β-cells and other cells that is involved in β-cell failure and regeneration.
[Archives of Physiology and Biochemistry]
Cross talk between exosomes and pancreatic β-cells in diabetes: Archives of Physiology and Biochemistry: Vol 0, No 0. (n.d.). Retrieved July 14, 2020, from https://www.tandfonline.com/doi/abs/10.1080/13813455.2020.1760303 Cite
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Modeling Type 1 Diabetes In Vitro Using Human Pluripotent Stem Cells

Investigators describe an in vitro platform that modeled features of human type 1 diabetes using stress-induced patient-derived endocrine cells and autologous immune cells.
[Cell Reports]
Leite, N. C., Sintov, E., Meissner, T. B., Brehm, M. A., Greiner, D. L., Harlan, D. M., & Melton, D. A. (2020). Modeling Type 1 Diabetes In Vitro Using Human Pluripotent Stem Cells. Cell Reports, 32(2). https://doi.org/10.1016/j.celrep.2020.107894 Cite
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Modeling Type 1 Diabetes In Vitro Using Human Pluripotent Stem Cells

To examine the interaction of immune cells and their cellular targets in type 1 diabetes, scientists differentiated human induced pluripotent stem cells into pancreatic endocrine cells, including β cells.
[Cell Reports]
Leite, N. C., Sintov, E., Meissner, T. B., Brehm, M. A., Greiner, D. L., Harlan, D. M., & Melton, D. A. (2020). Modeling Type 1 Diabetes In Vitro Using Human Pluripotent Stem Cells. Cell Reports, 32(2). https://doi.org/10.1016/j.celrep.2020.107894 Cite
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Advances Toward Engineering Functionally Mature Human Pluripotent Stem Cell-Derived β Cells

The authors review recent advances in the engineering of stem cell-derived β (SC-β) cells to understand and improve SC-β cell differentiation and functional maturation, particularly new differentiation strategies achieving dynamic glucose-responsive insulin secretion with rapid correction to normoglycemia when transplanted into diabetic mice.
[Frontiers in Bioengineering and Biotechnology]
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