β-cells

[Cell Death Discovery] Scientists investigated if TRAIL-R2 dependent signaling towards apoptosis can be induced in pancreatic β cells, whose loss by prolonged ER stress was associated with the onset of diabetes.

[Journal of Cachexia Sarcopenia and Muscle] Researchers assessed the functional, morphometric, biochemical, and molecular effects of P7C3 treatment in skeletal muscle of type 2 diabetic (db/db) mice.

[Experimental and Molecular Medicine] Using a cell culture system of NIT-1, an islet β cell line, scientists found that increased small ubiquitin-like modifier (SUMO) 2/3 conjugation to DRP1 due to SUMO-specific protease 2 (SENP2) deficiency suppressed the phosphorylation of DRP1, which possibly induced mitochondrial dysfunction.

[International Journal of Biological Macromolecules] Researchers investigated systematically the roles of a proteoglycan from Ganoderma lucidum in protection and repair of pancreatic β-cells against oxidative stress-induced injury and apoptosis on molecular, cellular and animal basis.

[Diabetes] Scientists assessed the global protein and individual protein tyrosine phosphatases (PTP) profiles in the pancreas from early onset non-obese diabetic mice treated with an anti-CD3 monoclonal antibody and interleukin-1 receptor antagonist.

[Experimental and Molecular Medicine] Researchers investigated the function of SENP2 in pancreatic β cells by generating a β cell-specific knockout mouse model.