AKT

[Scientific Reports] Scientists examined the antileukemic effects of pterostilbene, a natural methylated polyphenol analog of resveratrol that is predominantly found in berries and nuts, using various human and murine leukemic cells, as well as bone marrow samples obtained from patients with leukemia.

[Cancer Immunology Immunotherapy] Scientists investigated in vitro, ex vivo and in vivo effects of a novel chemical compound targeting HCK inhibition, in combination with the most used drugs for the treatment of myelodysplastic syndrome and de novo acute myeloid leukemia, 5-Azacytidine and Cytarabine.

[Stem Cell Research & Therapy] Scientists assessed the role of thymosin β-4 on endothelial function using diabetic human induced pluripotent stem cells derived endothelial cells as disease model of endothelial dysfunction.

[Cell Death Discovery] Scientists investigated the effects of hCAP18/LL-37 on hepatocellular carcinoma (HCC) in vitro and in vivo. Results showed that hCAP18/LL-37 overexpression significantly promoted the proliferation of cultured HCC cells and the growth of PLC/PRF-5 xenograft tumor.

[Clinical and Translational Oncology] Researchers aimed to investigate the role and underlying molecule mechanism of very-long-chain acyl-CoA dehydrogenase (VLCAD) in the pathological process of hepatocellular carcinoma.

[Nature Communications] Researchers demonstrated that a large subset of TNBC expressed significant levels of MAPK4, and this expression was critical for driving AKT activation independent of PI3K and promoting TNBC cell and xenograft growth.