AKT

[Oncogene] The authors evidenced that cholesterol promoted cell proliferation and invasion of lung adenocarcinoma (LAC) in vitro as well as LAC metastasis in vivo.

[Cell Death & Disease] The authors identified reverse signaling between glucocorticoid-induced tumour necrosis factor receptor (GITR) and its ligand (GITRL) as a cross-interaction pathway between immune cells and hepatic stem/progenitor cells that restricted the expansion of hepatic stem/progenitor cells and reduced the possibility of carcinogenesis.

[Haematologica] Scientists investigated the oncogenic function of TAL1 and the possible cooperation with PI3K-AKT pathway activation using isogenic pro-T cell cultures ex vivo and in vivo leukemia models.

[Scientific Reports] Cell viability assay revealed that apiin, rhoifolin, and vitexin could inhibit proliferation of PANC-1 and ASPC-1, with rhoifolin showing the maximum inhibitory effect.

[Cell Death & Disease] Investigators found that tripartite motif (TRIM) 46 promoted lung adenocarcinoma cell proliferation and cisplatin resistance by enhancing glycolysis.

[Cell Death Discovery] The authors demonstrated that HORMAD1 promotes the proliferation, migration and invasion of lung cancer cells both in vitro and in vivo by inducing epithelial–mesenchymal transition.