Exosomes from Human Umbilical Cord Mesenchymal Stem Cells Attenuate the Inflammation of Severe Steroid-Resistant Asthma by Reshaping Macrophage Polarization

Investigators evaluated the effects of MSC-exosomes on airway hyper responsiveness, inflammation, histopathology, and macrophage polarization in severe, steroid-resistant asthma in mice.
[Stem Cell Research & Therapy]
Dong, B., Wang, C., Zhang, J., Zhang, J., Gu, Y., Guo, X., Zuo, X., Pan, H., Hsu, A. C.-Y., Wang, G., & Wang, F. (2021). Exosomes from human umbilical cord mesenchymal stem cells attenuate the inflammation of severe steroid-resistant asthma by reshaping macrophage polarization. Stem Cell Research & Therapy, 12(1), 204. https://doi.org/10.1186/s13287-021-02244-6 Cite
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Inhibitory Effect of Immunologically Activated Mesenchymal Stem Cells on Lung Cancer Cell Growth and Metastasis

Human umbilical cord (HUC)-MSCs were separated from the umbilical cord using the adherence method. Surface markers of HUC-MSCs were detected by flow cytometry for MSC identification.
[Cancer Biotherapy and Radiopharmaceuticals]
Ye, H., Pan, J., Gong, E., Cai, X., Xu, C., Li, Y., Zheng, H., & Cao, Z. (2021). Inhibitory Effect of Immunologically Activated Mesenchymal Stem Cells on Lung Cancer Cell Growth and Metastasis. Cancer Biotherapy and Radiopharmaceuticals. https://doi.org/10.1089/cbr.2020.3855 Cite
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NGF Nanoparticles Enhance the Potency of Transplanted Human Umbilical Cord Mesenchymal Stem Cells for Myocardial Repair

In vitro, nerve growth factor significantly improved the proliferation of human umbilical cord MSCs and mitigated cytotoxicity and apoptosis under hypoxic injury.
[American Journal of Physiology-Heart and Circulatory Physiology]
Luo, W., Gong, Y., Qiu, F., Yuan, Y., Jia, W., Liu, Z., & Gao, L. (2021). NGF Nanoparticles Enhance the Potency of Transplanted Human Umbilical Cord Mesenchymal Stem Cells for Myocardial Repair. American Journal of Physiology-Heart and Circulatory Physiology. https://doi.org/10.1152/ajpheart.00855.2020 Cite
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AP-2alpha Regulates S-Phase and is a Marker for Sensitivity to PI3K-inhibitor Buparlisib in Colon Cancer

CRISPR-Cas9 and shRNA were used to eliminate TFAP2A expression in HCT116 and a panel of colon cancer cell lines.
[Molecular Cancer Research]
Beck, A. C., Cho, E., White, J. R., Paemka, L., Li, T., Gu, V. W., Thompson, D. T., Koch, K. E., Franke, C., Gosse, M., Wu, V. T., Landers, S. R., Pamatmat, A. J., Kulak, M. V., & Weigel, R. J. (2021). AP-2alpha Regulates S-phase and is a Marker for Sensitivity to PI3K-inhibitor Buparlisib in Colon Cancer. Molecular Cancer Research. https://doi.org/10.1158/1541-7786.MCR-20-0867 Cite
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Genetic Deletion of Nox4 Enhances Cancerogen-Induced Formation of Solid Tumors

By identifying NADPH oxidase 4 (Nox4) as a protective source of reactive oxygen species (ROS) in cancerogen-induced cancer, researchers provided a piece of knowledge for understanding the role of moderate production of ROS in preventing the initiation of malignancies.
[Proceedings of the National Academy of Sciences of the United States of America]
Helfinger, V., Gall, F. F. von, Henke, N., Kunze, M. M., Schmid, T., Rezende, F., Heidler, J., Wittig, I., Radeke, H. H., Marschall, V., Anderson, K., Shah, A. M., Fulda, S., Brüne, B., Brandes, R. P., & Schröder, K. (2021). Genetic deletion of Nox4 enhances cancerogen-induced formation of solid tumors. Proceedings of the National Academy of Sciences, 118(11). https://doi.org/10.1073/pnas.2020152118 Cite
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The Oncogene AAMDC Links PI3K-AKT-mTOR Signaling with Metabolic Reprograming in Estrogen Receptor-Positive Breast Cancer

Scientists uncovered that Adipogenesis associated Mth938 domain containing (AAMDC) regulates the expression of several metabolic enzymes involved in the one-carbon folate and methionine cycles, and lipid metabolism.
[Nature Communications]
Golden, E., Rashwan, R., Woodward, E. A., Sgro, A., Wang, E., Sorolla, A., Waryah, C., Tie, W. J., Cuyàs, E., Ratajska, M., Kardaś, I., Kozlowski, P., Johnstone, E. K. M., See, H. B., Duffy, C., Parry, J., Lagerborg, K. A., Czapiewski, P., Menendez, J. A., … Blancafort, P. (2021). The oncogene AAMDC links PI3K-AKT-mTOR signaling with metabolic reprograming in estrogen receptor-positive breast cancer. Nature Communications, 12(1), 1920. https://doi.org/10.1038/s41467-021-22101-7 Cite
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LINC01419-Mediated Epigenetic Silencing of ZIC1 Promotes Metastasis in Hepatocellular Carcinoma through thePI3K/Akt Signaling Pathway

LINC01419 enhances the methylation of zinc finger of the cerebellum (ZIC1) promoter, inhibits ZIC1 expression, and activates the PI3K/Akt signaling pathway, thereby enhancing the malignant phenotypes of hepatocellular carcinoma cells in vitro as well as tumor formation and metastasis in vivo.
[Laboratory Investigation]
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MZT2A Promotes NSCLC Viability and Invasion by Increasing Akt Phosphorylation via the MOZART2 Domain

Scientists showed that mitotic spindle organizing protein 2A (MZT2A) exhibited oncogenic activity by activating galectin‐3‐binding protein and Akt in NSCLC.
[Cancer Science]
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Targeting the AnxA1/Fpr2/ALX Pathway Regulates Neutrophil Function, Promoting Thromboinflammation Resolution in Sickle Cell Disease

Administration of annexin A1 mimetic peptide AnxA1Ac2-26 ameliorated cerebral thrombotic responses in sickle transgenic mice via regulation of the FPR2/ALX pathway.
[Blood]
Ansari, J., Senchenkova, E. Y., Vital, S. A., Al-Yafeai, Z., Kaur, G., Sparkenbaugh, E. M., Orr, A. W., Pawlinski, R., Hebbel, R. P., Granger, D. N., Kubes, P., & Gavins, F. N. E. (2021). Targeting the AnxA1/Fpr2/ALX pathway regulates neutrophil function, promoting thromboinflammation resolution in sickle cell disease. Blood, 137(11), 1538–1549. https://doi.org/10.1182/blood.2020009166 Cite
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Stomatin-Mediated Inhibition of the Akt Signaling Axis Suppresses Tumor Growth

Investigators found that stomatin expression was markedly upregulated by the interaction between prostate cancer cells and stromal cells.
[Cancer Research]
Rahman, N. I. A., Sato, A., Tsevelnorov, K., Shimizu, A., Komeno, M., Amin, M. K. B. A., Molla, M. R., Soh, J. E. C., Nguyen, L. K. C., Wada, A., Kawauchi, A., & Ogita, H. (2021). Stomatin-mediated inhibition of the Akt signaling axis suppresses tumor growth. Cancer Research. https://doi.org/10.1158/0008-5472.CAN-20-2331 Cite
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HIF1α/HIF2α–Sox2/Klf4 Promotes the Malignant Progression of Glioblastoma via the EGFR–PI3K/AKT Signaling Pathway with Positive Feedback under Hypoxia

Scientists discovered that glioblastoma cells exhibited features indicative of malignant progression and were present in a hypoxic environment.
[Cell Death & Disease]
HIF1α/HIF2α–Sox2/Klf4 promotes the malignant progression of glioblastoma via the EGFR–PI3K/AKT signalling pathway with positive feedback under hypoxia | Cell Death & Disease. (n.d.). Retrieved March 24, 2021, from https://www.nature.com/articles/s41419-021-03598-8 Cite
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