Anlotinib Suppresses Tumor Progression via Blocking the VEGFR2/PI3K/Akt Cascade in Intrahepatic Cholangiocarcinoma

Using in vitro experiments, investigators found that anlotinib had significant effects on proliferation inhibition, migration and invasion restraint, and cell-cycle arrestment in intrahepatic cholangiocarcinoma.
[Cell Death & Disease]
Song, F., Hu, B., Cheng, J.-W., Sun, Y.-F., Zhou, K.-Q., Wang, P.-X., Guo, W., Zhou, J., Fan, J., Chen, Z., & Yang, X.-R. (2020). Anlotinib suppresses tumor progression via blocking the VEGFR2/PI3K/AKT cascade in intrahepatic cholangiocarcinoma. Cell Death & Disease, 11(7), 1–14. https://doi.org/10.1038/s41419-020-02749-7 Cite
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Targeting Disseminated Estrogen-Receptor-Positive Breast Cancer Cells in Bone Marrow

Investigators utilized a 3D co-culture model incorporating estrogen receptor-positive breast cancer cells and bone marrow mesenchymal stem cells to represent disseminated tumors cells in a bone marrow niche.
[Oncogene]
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SOX2 and p53 Expression Control Converges in PI3K/AKT Signaling with Versatile Implications for Stemness and Cancer

The authors summarize the latest advances in the understanding of PI3K/AKT/SOX2-driven stemness and its intertwined relations to p53-signaling in DNA damage response under conditions of pluripotency, reprogramming, and transformation.
[International Journal of Molecular Sciences]
Schaefer, T., Steiner, R., & Lengerke, C. (2020). SOX2 and p53 Expression Control Converges in PI3K/AKT Signaling with Versatile Implications for Stemness and Cancer. International Journal of Molecular Sciences, 21(14), 4902. https://doi.org/10.3390/ijms21144902 Cite
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Insulin Signaling and Glucose Metabolism in Different Hepatoma Cell Lines Deviate from Hepatocyte Physiology toward a Convergent Aberrant Phenotype

The authors investigated insulin signaling, gluconeogenic gene expression, glucose production, and fatty acid synthase abundance in primary hepatocytes and in HepG2, Hepa 1–6, and McARH7777 hepatoma cell lines.
[Scientific Reports]
Molinaro, A., Becattini, B., & Solinas, G. (2020). Insulin signaling and glucose metabolism in different hepatoma cell lines deviate from hepatocyte physiology toward a convergent aberrant phenotype. Scientific Reports, 10(1), 12031. https://doi.org/10.1038/s41598-020-68721-9 Cite
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A Novel 4-Aminoquinazoline Derivative, DHW-208, Suppresses the Growth of Human Breast Cancer Cells by Targeting the PI3K/AKT/mTOR Pathway

Researchers report for the first time that DHW-208 suppressed the growth of human breast cancer cells by inhibiting the PI3K/AKT/mTOR-signaling pathway both in vivo and in vitro.
[Cell Death & Disease]
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