ATR Is Essential for Preservation of Cell Mechanics and Nuclear Integrity during Interstitial Migration

ATR-defective cells were defective in neuronal migration during development and in metastatic dissemination from circulating tumor cells.
[Nature Communications]
Kidiyoor, G. R., Li, Q., Bastianello, G., Bruhn, C., Giovannetti, I., Mohamood, A., Beznoussenko, G. V., Mironov, A., Raab, M., Piel, M., Restuccia, U., Matafora, V., Bachi, A., Barozzi, S., Parazzoli, D., Frittoli, E., Palamidessi, A., Panciera, T., Piccolo, S., … Foiani, M. (2020). ATR is essential for preservation of cell mechanics and nuclear integrity during interstitial migration. Nature Communications, 11(1), 4828. https://doi.org/10.1038/s41467-020-18580-9 Cite
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PCAF-Mediated Histone Acetylation Promotes Replication Fork Degradation by MRE11 and EXO1 in BRCA-Deficient Cells

Researchers report the histone acetyltransferase PCAF as a fork-associated protein that promotes fork degradation in BRCA-deficient cells by acetylating H4K8 at stalled replication forks, which recruits MRE11 and EXO1.
[Molecular Cell]
Kim, J. J., Lee, S. Y., Choi, J.-H., Woo, H. G., Xhemalce, B., & Miller, K. M. (2020). PCAF-Mediated Histone Acetylation Promotes Replication Fork Degradation by MRE11 and EXO1 in BRCA-Deficient Cells. Molecular Cell, 0(0). https://doi.org/10.1016/j.molcel.2020.08.018 Cite
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EB Virus-Induced ATR Activation Accelerates Nasopharyngeal Carcinoma Growth via M2-Type Macrophages Polarization

Scientists showed that Epstein–Barr virus could promote the expression of p-ATR and M2-type TAMs transformation in clinical nasopharyngeal carcinoma specimens.
[Cell Death & Disease]
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Dynamic Remodelling of the Human Host Cell Proteome and Phosphoproteome upon Enterovirus Infection

The authors describe an unbiased, system-wide and time-resolved analysis of the proteome and phosphoproteome of human cells infected with coxsackievirus B3.
[Nature Communications]
Giansanti, P., Strating, J. R. P. M., Defourny, K. A. Y., Cesonyte, I., Bottino, A. M. S., Post, H., Viktorova, E. G., Ho, V. Q. T., Langereis, M. A., Belov, G. A., Nolte-‘t Hoen, E. N. M., Heck, A. J. R., & van Kuppeveld, F. J. M. (2020). Dynamic remodelling of the human host cell proteome and phosphoproteome upon enterovirus infection. Nature Communications, 11(1), 4332. https://doi.org/10.1038/s41467-020-18168-3 Cite
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p53 Activation during Ribosome Biogenesis Regulates Normal Erythroid Differentiation

A detailed characterization of ribosome biogenesis dynamics during human and murine erythropoiesis shows that ribosome biogenesis is abruptly interrupted by the drop of rDNA transcription and the collapse of ribosomal protein neo-synthesis.
[Blood]
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Inhibition of miR-1193 Leads to Synthetic Lethality in Glioblastoma Multiforme Cells Deficient of DNA-PKcs

By implementing a highly efficient high-throughput screening platform using an in-house-constructed genome-wide human microRNA inhibitor library, scientists demonstrated that miR-1193 inhibition sensitized glioblastoma multiforme tumor cells with DNA-PKcs deficiency.
[Cell Death & Disease]
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