B cells

[Pediatric Research] The authors evaluated the prognostic value of Sal-like protein 4 transcription factor (SALL4) and B cell-specific Moloney murine leukemia virus integration site 1 (BMI-1) in children with acute lymphoblastic leukemia.

[Experimental Hematology] Recent findings have shown the critical roles of signal-transducing adaptor protein (STAP)-2 in B cell progenitor cells in marrow under hematopoietic stress and STAP-1 and -2 in BCR-ABL-transduced leukemogenesis. In this review, the authors focus on the role of STAPs in the bone marrow.

[Haematologica] The authors retrospectively reviewed the characteristics and outcomes of adult patients with relapsed/refractory large B-cell lymphoma treated with Standard of care axicabtagene ciloleucel or tisagenlecleucel .

[Cell Chemical Biology] To enable tumor-localized immunotherapy following intravenous administration, investigators chemically conjugated a polyspecific integrin-binding peptide (PIP) to an immunostimulant to generate a tumor-targeted immunomodulatory agent, referred to as PIP-CpG.

[Oncogene] Researchers showed that the activation of the RON receptor tyrosine kinase signaling pathway specifically in macrophages supports breast cancer growth and metastasis.

[Science Advances] Scientists explored a critical role for programmed cell death 1 (PD-1) in brain tumor–initiating cells and uncovered a nonimmune resistance mechanism of patients with glioblastoma to PD-1– or programmed cell death ligand 1 (PD-L1)–blocking therapies.