Scientists investigated the regulatory mechanisms regulated by hypoxia-inducing factors (HIFs) and SOX2 in endometrial cancer stem cells (ECSCs) during endometrial cancer (EC) development. ECSCs isolated from EC cell lines and tissues were found to express stemness genes.
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Researchers investigated changes in expression levels of the cancer stem cell (CSC) biomarker, cluster of differentiation 133 (CD133), from primary ovarian cancer (OC) cell lines to induction of CSC-spheres in an attempt to explore the mechanisms related to modulation of stemness, drug resistance, and tumorigenesis in CSCs, thus facilitating the search for new therapeutics for OC.
[International Journal of Molecular Sciences]
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Investigators showed that SPARC-related modular calcium-binding protein 2 transcript level was higher in colorectal cancer samples than in normal mucosa; this level was not associated with candidate cancer stem cell markers or intestinal stem cell markers except for OLFM4.
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Researchers showed that SPARC-related modular calcium-binding protein 2 (SMOC2) transcript level was higher in colorectal cancer samples than in normal mucosa; this level was not associated with candidate cancer stem cell markers or intestinal stem cell markers except for OLFM4.
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Scientists established a CD133+ cell-rich subline from Capan-1 pancreatic cancer cells as a pancreatic cancer stem cell model and compared the effects of KU-0063794, a dual mTORC1/mTORC2 inhibitor, against those of mTORC1-specific rapamycin.
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Researchers discovered that increased iroquois-class homeodomain protein 4 (IRX4) was related to gefitinib resistance in non-small cell lung cancer (NSCLC) cells. Knockdown of IRX4 inhibited cell proliferation, sphere formation, and the expression of CD133, ALDH1A1, NANOG, Sox2 and Notch1, and the transcriptional activity of NANOG promoter.
[Cell Death & Disease]
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CD34+ and CD133+ were longitudinally detected by flow cytometry in the maternal plasma of 29 healthy controls and nine multiple sclerosis patients and in the cord blood of their newborns.
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Mallucci, G., Beneventi, F., Bergamaschi, R., Bizzotto, C., Cavagnoli, C., De Maggio, I., Bellingeri, C., Monti, C., Viarengo, G., & Spinillo, A. (2020). Circulating endothelial progenitor cells during pregnancy in multiple sclerosis. Neurological Sciences. https://doi.org/10.1007/s10072-020-04648-3 Cite
The authors studied function recovery at the scar zone and its impact in global left ventricular function after intracoronary injection of hematopoietic precursor cells.
[ESC Heart Failure]
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Based on the methods for isolating and identifying cancer stem cells and the functional features of long-term tumor-initiating cells (LT-TICs), the authors aimed to identify a subpopulation of LT-TICs.
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Scientists provide a new in vitro long‐term culture model for a specific subpopulation of liver cancer stem cells enriched by cell surface markers.
[Febs Open Bio]
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