microRNA-211-Mediated Targeting of the INHBA-TGF-β Axis Suppresses Prostate Tumor Formation and Growth

Scientists indicated that upregulation of miR-211 has tumor-suppressive properties by inhibiting TGF-β pathway activation via INHBA in prostate cancer stem cells.
[Cancer Gene Therapy]
Zhao, Z., Wang, K., & Tan, S. (2020). microRNA-211-mediated targeting of the INHBA-TGF-β axis suppresses prostate tumor formation and growth. Cancer Gene Therapy, 1–15. https://doi.org/10.1038/s41417-020-00237-w Cite
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Cancer Stem Cell Markers in Relation to Patient Survival Outcomes: Lessons for Integrative Diagnostics and Next-Generation Anticancer Drug Development

Researchers report original findings on expression and prognostic significance of CSC markers in several cancers. They examined and compared the transcriptional expression of CSC markers in tumor tissues versus the adjacent normal tissues using publicly available databases, The Cancer Genome Atlas and Gene Expression Profiling Interactive Analysis.
[Omics-A Journal of integrative Biology]
Dzobo, K., Ganz, C., Thomford, N. E., & Senthebane, D. A. (2020). Cancer Stem Cell Markers in Relation to Patient Survival Outcomes: Lessons for Integrative Diagnostics and Next-Generation Anticancer Drug Development. OMICS: A Journal of Integrative Biology. https://doi.org/10.1089/omi.2020.0185 Cite
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PARK7 Maintains the Stemness of Glioblastoma Stem Cells by Stabilizing Epidermal Growth Factor Receptor Variant III

Deregulation of PARK7 has been implicated in the pathogenesis of various human diseases, including cancer. Scientists clarified the effect of PARK7 on stemness and radioresistance of glioblastoma stem cells.
[Oncogene]
Kim, J.-Y., Kim, H.-J., Jung, C.-W., Choi, B.-I., Lee, D.-H., & Park, M.-J. (2020). PARK7 maintains the stemness of glioblastoma stem cells by stabilizing epidermal growth factor receptor variant III. Oncogene, 1–14. https://doi.org/10.1038/s41388-020-01543-1 Cite
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Secretory Mucin 5AC Promotes Neoplastic Progression by Augmenting KLF4-Mediated Pancreatic Cancer Cell Stemness

High-throughput RNA-sequencing analysis from pancreatic tissues of KCM animals revealed a significant decrease in cancer stem cell markers Aldh1a1, Klf4, EpCAM, and CD133.
[Cancer Research]
Ganguly, K., Krishn, S. R., Rachagani, S., Jahan, R., Shah, A., Nallasamy, P., Rauth, S., Atri, P., Cox, J. L., Pothuraju, R., Smith, L. M., Ayala, S., Evans, C., Ponusamy, M. P., Kumar, S., Kaur, S., & Batra, S. K. (2020). Secretory mucin 5AC promotes neoplastic progression by augmenting KLF4-mediated pancreatic cancer cell stemness. Cancer Research. https://doi.org/10.1158/0008-5472.CAN-20-1293 Cite
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Metabolic Programming of Distinct Cancer Stem Cells Promotes Metastasis of Pancreatic Ductal Adenocarcinoma

Scientists investigated the role of distinct subtypes of pancreatic cancer stem cells and their metabolomic signatures in organ-specific metastatic colonization.
[Oncogene]
Nimmakayala, R. K., Leon, F., Rachagani, S., Rauth, S., Nallasamy, P., Marimuthu, S., Shailendra, G. K., Chhonker, Y. S., Chugh, S., Chirravuri, R., Gupta, R., Mallya, K., Prajapati, D. R., Lele, S. M., C. Caffrey, T., L. Grem, J., Grandgenett, P. M., Hollingsworth, M. A., Murry, D. J., … Ponnusamy, M. P. (2020). Metabolic programming of distinct cancer stem cells promotes metastasis of pancreatic ductal adenocarcinoma. Oncogene, 1–17. https://doi.org/10.1038/s41388-020-01518-2 Cite
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IL-8/CXCR2 Mediates Tropism of Human Bone Marrow-Derived Mesenchymal Stem Cells toward CD133+/CD44+ Colon Cancer Stem Cells

Scientists compared the effects of three tissue‐derived mesenchynal stem cells (MSCs) in vivo on colon tumor xenograft growth. Then, they analyzed the tropism of bone marrow‐derived MSCs toward normal intestinal epithelial cells, parental colon cancer cells, CD133/CD44, and CD133+/CD44+ colon cancer cells in vitro.
[Journal of Cellular Physiology]
Ma, X., Chen, J., Liu, J., Xu, B., Liang, X., Yang, X., Feng, Y., Liang, X., & Liu, J. (n.d.). IL-8/CXCR2 mediates tropism of human bone marrow-derived mesenchymal stem cells toward CD133+/CD44+ Colon cancer stem cells. Journal of Cellular Physiology, n/a(n/a). https://doi.org/10.1002/jcp.30080 Cite
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Tideglusib Attenuates Growth of Neuroblastoma Cancer Stem/Progenitor Cells In Vitro and In Vivo by Specifically Targeting GSK-3β

Investigators evaluated the potential anti-tumor effect of Tideglusib, an irreversible glycogen synthase kinase (GSK)-3β inhibitor drug, on three human neuroblastoma cell lines, SK-N-SH, SH-SY5Y, and IMR-32.
[Pharmacological Reports]
Bahmad, H. F., Chalhoub, R. M., Harati, H., Bou-Gharios, J., Assi, S., Ballout, F., Monzer, A., Msheik, H., Araji, T., Elajami, M. K., Ghanem, P., Chamaa, F., Kadara, H., Abou-Antoun, T., Daoud, G., Fares, Y., & Abou-Kheir, W. (2020). Tideglusib attenuates growth of neuroblastoma cancer stem/progenitor cells in vitro and in vivo by specifically targeting GSK-3β. Pharmacological Reports. https://doi.org/10.1007/s43440-020-00162-7 Cite
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Therapeutic Angiogenesis Using Autologous Adipose-Derived Regenerative Cells in Patients with Critical Limb Ischaemia in Japan: A Clinical Pilot Study

Adipose tissue was obtained by ordinary liposuction method. Isolated ADRCs were injected into the ischaemic limb. Scientists performed TACT-ADRC procedure in five patients with CLI.
[Scientific Reports]
Therapeutic angiogenesis using autologous adipose-derived regenerative cells in patients with critical limb ischaemia in Japan: a clinical pilot study | Scientific Reports. (n.d.). Retrieved October 5, 2020, from https://www.nature.com/articles/s41598-020-73096-y Cite
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DCLK1, a Putative Novel Stem Cell Marker in Human Cholangiocarcinoma

Investigators evaluated in vitro the expression and the biological function of DCLK1 in intrahepatic cholangiocarcinom (CCA) and perihilar CCA.
[Hepatology]
Nevi, L., Matteo, S. D., Carpino, G., Zizzari, I., Safarikia, S., Ambrosino, V., Costantini, D., Overi, D., Giancotti, A., Monti, M., Bosco, D., Peppo, V. D., Oddi, A., Rose, A. M. D., Melandro, F., Bragazzi, M. C., Faccioli, J., Massironi, S., Grazi, G. L., … Alvaro, D. (n.d.). DCLK1, a putative novel stem cell marker in human cholangiocarcinoma. Hepatology, n/a(n/a). https://doi.org/10.1002/hep.31571 Cite
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Hypoxia Induces an Endometrial Cancer Stem-Like Cell Phenotype via HIF-Dependent Demethylation of SOX2 mRNA

Scientists investigated the regulatory mechanisms regulated by hypoxia-inducing factors (HIFs) and SOX2 in endometrial cancer stem cells (ECSCs) during endometrial cancer (EC) development. ECSCs isolated from EC cell lines and tissues were found to express stemness genes.
[Oncogenesis]
Chen, G., Liu, B., Yin, S., Li, S., Guo, Y., Wang, M., Wang, K., & Wan, X. (2020). Hypoxia induces an endometrial cancer stem-like cell phenotype via HIF-dependent demethylation of SOX2 mRNA. Oncogenesis, 9(9), 1–14. https://doi.org/10.1038/s41389-020-00265-z Cite
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Characteristics of CD133-Sustained Chemoresistant Cancer Stem-Like Cells in Human Ovarian Carcinoma

Researchers investigated changes in expression levels of the cancer stem cell (CSC) biomarker, cluster of differentiation 133 (CD133), from primary ovarian cancer (OC) cell lines to induction of CSC-spheres in an attempt to explore the mechanisms related to modulation of stemness, drug resistance, and tumorigenesis in CSCs, thus facilitating the search for new therapeutics for OC.
[International Journal of Molecular Sciences]
Liu, C. L., Chen, Y. J., Fan, M. H., Liao, Y. J., & Mao, T. L. (2020). Characteristics of CD133-Sustained Chemoresistant Cancer Stem-Like Cells in Human Ovarian Carcinoma. International Journal of Molecular Sciences, 21(18), 6467. https://doi.org/10.3390/ijms21186467 Cite
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