The Combination Effect of Prominin1 (CD133) Suppression and Oxaliplatin Treatment in Colorectal Cancer Therapy

Scientists checked the combined effect of CD133 siRNA and Oxaliplatin on proliferation, migration, apoptosis, and stemness properties of olorectal cancer cells in the HT-29 cell line.
[Biomedicine & Pharmacotherapy]
Asadzadeh, Z., Mansoori, B., Mohammadi, A., Kazemi, T., Mokhtarzadeh, A., Shanehbandi, D., Hemmat, N., Derakhshani, A., Brunetti, O., Safaei, S., Aghajani, M., Najafi, S., Silvestris, N., & Baradaran, B. (2021). The combination effect of Prominin1 (CD133) suppression and Oxaliplatin treatment in colorectal cancer therapy. Biomedicine & Pharmacotherapy, 137, 111364. https://doi.org/10.1016/j.biopha.2021.111364 Cite
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Regulatory T Cells Promote Glioma Cell Stemness through TGF-β–NF-κB–IL6–STAT3 Signaling

Mechanistic investigations indicated that TGF-β acted on cancer cells to induce the core cancer stem cell-related genes CD133, SOX2, NESTIN, MUSASHI1 and ALDH1A expression and spheres formation via NF-κB–IL6–STAT3 signaling pathway, resulting in the increased cancer stemness and tumorigenic potential.
[Cancer Immunology Immunotherapy]
Regulatory T cells promote glioma cell stemness through TGF-β–NF-κB–IL6–STAT3 signaling | SpringerLink. (n.d.). Retrieved February 17, 2021, from https://link.springer.com/article/10.1007%2Fs00262-021-02872-0 Cite
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IL-6 and IL-8, Secreted by Myofibroblasts in the Tumor Microenvironment, Activate HES1 to Expand the Cancer Stem Cell Population in Early Colorectal Tumor

Scientists investigated the cancer stem cell‐promoting effect of factors released from myofibroblasts into the microenvironment of early colorectal cancer tumors and its molecular mechanism.
[Molecular Carcinogenesis]
Kim, B., Seo, Y., Kwon, J.-H., Shin, Y., Kim, S., Park, S. J., Park, J. J., Cheon, J. H., Kim, W. H., & Kim, T. I. (n.d.). IL-6 and IL-8, secreted by myofibroblasts in the tumor microenvironment, activate HES1 to expand the cancer stem cell population in early colorectal tumor. Molecular Carcinogenesis, n/a(n/a). https://doi.org/https://doi.org/10.1002/mc.23283 Cite
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Circulatory Shear Stress Induces Molecular Changes and Side Population Enrichment in Primary Tumor-Derived Lung Cancer Cells with Higher Metastatic Potential

Scientists engineered a closed-loop fluidic system to analyze molecular changes induced by variations in flow rate and pressure on primary tumor-derived lung adenocarcinoma cells.
[Scientific Reports]
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PI3K/Akt Pathway and Nanog Maintain Cancer Stem Cells in Sarcomas

Levels of Nanog and activated Akt were significantly higher in sarcoma cells grown as spheroids or sorted for CD133 expression to enrich for cancer stem cells.
[Oncogenesis]
Yoon, C., Lu, J., Yi, B. C., Chang, K. K., Simon, M. C., Ryeom, S., & Yoon, S. S. (2021). PI3K/Akt pathway and Nanog maintain cancer stem cells in sarcomas. Oncogenesis, 10(1), 1–14. https://doi.org/10.1038/s41389-020-00300-z Cite
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Advances in Liver Cancer Stem Cell Isolation and their Characterization

Investigators review the research progress made in the isolation and characterization of liver cancer stem cells by considering a wide range of cell surface markers and sorting methods, as applied to side populations, microsphere cultures and the gradient centrifugation method.
[Stem Cell Reviews and Reports]
Liu, L., & Borlak, J. (2021). Advances in Liver Cancer Stem Cell Isolation and their Characterization. Stem Cell Reviews and Reports. https://doi.org/10.1007/s12015-020-10114-6 Cite
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Chemotherapy-Enriched THBS2-Deficient Cancer Stem Cells Drive Hepatocarcinogenesis through Matrix Softness Induced Histone H3 Modifications

The local soft spots created by liver cancer stem cells could enhance stemness and drug resistance and provide a route of escape to facilitate hepatocellular carcinoma metastasis.
[Advanced Science]
Ng, K.-Y., Shea, Q. T., Wong, T.-L., Luk, S. T., Tong, M., Lo, C.-M., Man, K., Yun, J.-P., Guan, X.-Y., Lee, T. K., Zheng, Y.-P., & Ma, S. (n.d.). Chemotherapy-Enriched THBS2-Deficient Cancer Stem Cells Drive Hepatocarcinogenesis through Matrix Softness Induced Histone H3 Modifications. Advanced Science, n/a(n/a), 2002483. https://doi.org/https://doi.org/10.1002/advs.202002483 Cite
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The Effect of Proprotein Convertase Subtilisin Kexin Type 9 Inhibitors on Circulating Endothelial Progenitor Cells in Patients with Cardiovascular Disease

Scientists explored the effect of proprotein convertase subtilisin kexin type 9 inhibitors on circulating endothelial progenitor cells hypothesizing a possible pleiotropic effect.
[Cardiovascular Drugs and Therapy]
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Allogeneic Human Umbilical Cord Wharton’s Jelly Stem Cells Increase Several-Fold the Expansion of Human Cord Blood CD34+ Cells Both In Vitro and In Vivo

Scientists performed an in-depth evaluation of the primitiveness, migration, adhesion, maturation, mitochondrial behavior, and pathway mechanisms of this platform using conventional assays followed by the evaluation of engraftment potential of the expanded CD34+ cells in an in vivo murine model.
[Stem Cell Research & Therapy]
Allogeneic human umbilical cord Wharton’s jelly stem cells increase several-fold the expansion of human cord blood CD34+ cells both in vitro and in vivo | Stem Cell Research & Therapy | Full Text. (n.d.). Retrieved December 16, 2020, from https://stemcellres.biomedcentral.com/articles/10.1186/s13287-020-02048-0 Cite
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Cell Softness Regulates Tumorigenicity and Stemness of Cancer Cells

Researchers showed that microfluidic devices could be used to sort marker‐based heterogeneous CSC into mechanically stiff and soft subpopulations. The isolated soft tumor cells but not the stiff ones could form a tumor in immunocompetent mice with 100 cells per inoculation.
[EMBO Journal]
Lv, J., Liu, Y., Cheng, F., Li, J., Zhou, Y., Zhang, T., Zhou, N., Li, C., Wang, Z., Ma, L., Liu, M., Zhu, Q., Liu, X., Tang, K., Ma, J., Zhang, H., Xie, J., Fang, Y., Zhang, H., … Huang, B. (2020). Cell softness regulates tumorigenicity and stemness of cancer cells. The EMBO Journal, n/a(n/a), e106123. https://doi.org/10.15252/embj.2020106123 Cite
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microRNA-211-Mediated Targeting of the INHBA-TGF-β Axis Suppresses Prostate Tumor Formation and Growth

Scientists indicated that upregulation of miR-211 has tumor-suppressive properties by inhibiting TGF-β pathway activation via INHBA in prostate cancer stem cells.
[Cancer Gene Therapy]
Zhao, Z., Wang, K., & Tan, S. (2020). microRNA-211-mediated targeting of the INHBA-TGF-β axis suppresses prostate tumor formation and growth. Cancer Gene Therapy, 1–15. https://doi.org/10.1038/s41417-020-00237-w Cite
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