Scientists checked the combined effect of CD133 siRNA and Oxaliplatin on proliferation, migration, apoptosis, and stemness properties of olorectal cancer cells in the HT-29 cell line.
[Biomedicine & Pharmacotherapy]
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Asadzadeh, Z., Mansoori, B., Mohammadi, A., Kazemi, T., Mokhtarzadeh, A., Shanehbandi, D., Hemmat, N., Derakhshani, A., Brunetti, O., Safaei, S., Aghajani, M., Najafi, S., Silvestris, N., & Baradaran, B. (2021). The combination effect of Prominin1 (CD133) suppression and Oxaliplatin treatment in colorectal cancer therapy. Biomedicine & Pharmacotherapy, 137, 111364. https://doi.org/10.1016/j.biopha.2021.111364 Cite
Mechanistic investigations indicated that TGF-β acted on cancer cells to induce the core cancer stem cell-related genes CD133, SOX2, NESTIN, MUSASHI1 and ALDH1A expression and spheres formation via NF-κB–IL6–STAT3 signaling pathway, resulting in the increased cancer stemness and tumorigenic potential.
[Cancer Immunology Immunotherapy]
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Regulatory T cells promote glioma cell stemness through TGF-β–NF-κB–IL6–STAT3 signaling | SpringerLink. (n.d.). Retrieved February 17, 2021, from https://link.springer.com/article/10.1007%2Fs00262-021-02872-0 Cite
Scientists investigated the cancer stem cell‐promoting effect of factors released from myofibroblasts into the microenvironment of early colorectal cancer tumors and its molecular mechanism.
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Kim, B., Seo, Y., Kwon, J.-H., Shin, Y., Kim, S., Park, S. J., Park, J. J., Cheon, J. H., Kim, W. H., & Kim, T. I. (n.d.). IL-6 and IL-8, secreted by myofibroblasts in the tumor microenvironment, activate HES1 to expand the cancer stem cell population in early colorectal tumor. Molecular Carcinogenesis, n/a(n/a). https://doi.org/https://doi.org/10.1002/mc.23283 Cite
Scientists engineered a closed-loop fluidic system to analyze molecular changes induced by variations in flow rate and pressure on primary tumor-derived lung adenocarcinoma cells.
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Levels of Nanog and activated Akt were significantly higher in sarcoma cells grown as spheroids or sorted for CD133 expression to enrich for cancer stem cells.
Investigators review the research progress made in the isolation and characterization of liver cancer stem cells by considering a wide range of cell surface markers and sorting methods, as applied to side populations, microsphere cultures and the gradient centrifugation method.
[Stem Cell Reviews and Reports]
The local soft spots created by liver cancer stem cells could enhance stemness and drug resistance and provide a route of escape to facilitate hepatocellular carcinoma metastasis.
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Ng, K.-Y., Shea, Q. T., Wong, T.-L., Luk, S. T., Tong, M., Lo, C.-M., Man, K., Yun, J.-P., Guan, X.-Y., Lee, T. K., Zheng, Y.-P., & Ma, S. (n.d.). Chemotherapy-Enriched THBS2-Deficient Cancer Stem Cells Drive Hepatocarcinogenesis through Matrix Softness Induced Histone H3 Modifications. Advanced Science, n/a(n/a), 2002483. https://doi.org/https://doi.org/10.1002/advs.202002483 Cite
Scientists explored the effect of proprotein convertase subtilisin kexin type 9 inhibitors on circulating endothelial progenitor cells hypothesizing a possible pleiotropic effect.
[Cardiovascular Drugs and Therapy]
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Scientists performed an in-depth evaluation of the primitiveness, migration, adhesion, maturation, mitochondrial behavior, and pathway mechanisms of this platform using conventional assays followed by the evaluation of engraftment potential of the expanded CD34+ cells in an in vivo murine model.
[Stem Cell Research & Therapy]
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Allogeneic human umbilical cord Wharton’s jelly stem cells increase several-fold the expansion of human cord blood CD34+ cells both in vitro and in vivo | Stem Cell Research & Therapy | Full Text. (n.d.). Retrieved December 16, 2020, from https://stemcellres.biomedcentral.com/articles/10.1186/s13287-020-02048-0 Cite
Researchers showed that microfluidic devices could be used to sort marker‐based heterogeneous CSC into mechanically stiff and soft subpopulations. The isolated soft tumor cells but not the stiff ones could form a tumor in immunocompetent mice with 100 cells per inoculation.
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Lv, J., Liu, Y., Cheng, F., Li, J., Zhou, Y., Zhang, T., Zhou, N., Li, C., Wang, Z., Ma, L., Liu, M., Zhu, Q., Liu, X., Tang, K., Ma, J., Zhang, H., Xie, J., Fang, Y., Zhang, H., … Huang, B. (2020). Cell softness regulates tumorigenicity and stemness of cancer cells. The EMBO Journal, n/a(n/a), e106123. https://doi.org/10.15252/embj.2020106123 Cite
Scientists indicated that upregulation of miR-211 has tumor-suppressive properties by inhibiting TGF-β pathway activation via INHBA in prostate cancer stem cells.
[Cancer Gene Therapy]