LncRNA SLCO4A1-AS1 Modulates Colon Cancer Stem Cell Properties by Binding to miR-150-3p and Positively Regulating SLCO4A1

The authors explored the specific role of solute carrier organic anion transporter family member 4A1-AS1 (SLCO4A1-AS1) in colon CSCs.
[Laboratory Investigation]
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Monitoring Levels of Vimentin-Positive Circulating Cancer Stem Cells and Tumor Cells in Patients with Advanced EGFR-Mutated Non-Small Cell Lung Cancer

The cell surface vimentin antibody was used for circulating tumor cells (CTCs) detection and CD133 antibody for CCSC detection.
[Lung Cancer]
Hsu, C.-L., Tsai, T.-H., Huang, C.-K., Yang, C.-Y., Liao, W.-Y., Ho, C.-C., Ruan, S.-Y., Chen, K.-Y., Shih, J.-Y., & Yang, P.-C. (2021). Monitoring levels of vimentin-positive circulating cancer stem cells and tumor cells in patients with advanced EGFR-mutated non-small cell lung cancer. Lung Cancer, 156, 50–58. https://doi.org/10.1016/j.lungcan.2021.04.014 Cite
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CRISPR/Cas9-Mediated Knockout of PIM3 Suppresses Tumorigenesis and Cancer Cell Stemness in Human Hepatoblastoma Cells

Scientists use dCRISPR/Cas9 gene editing with dual gRNAs to introduce large inactivating deletions in the PIM3 gene and achieve stable PIM3 knockout in the human hepatoblastoma cell line, HuH6.
[Cancer Gene Therapy]
Marayati, R., Stafman, L. L., Williams, A. P., Bownes, L. V., Quinn, C. H., Markert, H. R., Easlick, J. L., Stewart, J. E., Crossman, D. K., Mroczek-Musulman, E., & Beierle, E. A. (2021). CRISPR/Cas9-mediated knockout of PIM3 suppresses tumorigenesis and cancer cell stemness in human hepatoblastoma cells. Cancer Gene Therapy, 1–15. https://doi.org/10.1038/s41417-021-00334-4 Cite
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Morphological and Molecular Characteristics of Spheroid Formation in HT-29 and Caco-2 Colorectal Cancer Cell Lines

Colorectal cancer spheroids were developed using hanging drop and forced floating in serum-free and non-attachment conditions and their morphological features were evaluated by scanning electron microscopy.
[Cancer Cell International]
Gheytanchi, E., Naseri, M., Karimi-Busheri, F., Atyabi, F., Mirsharif, E. S., Bozorgmehr, M., Ghods, R., & Madjd, Z. (2021). Morphological and molecular characteristics of spheroid formation in HT-29 and Caco-2 colorectal cancer cell lines. Cancer Cell International, 21(1), 204. https://doi.org/10.1186/s12935-021-01898-9 Cite
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Phenotypic Characterization of Leukemia-Initiating Stem Cells in Chronic Myelomonocytic Leukemia

Scientists found that leukemic stem cells in chronic myelomonocytic leukemia resided in a CD34+/CD38 fraction of the malignant clone.
[Leukemia]
Eisenwort, G., Sadovnik, I., Keller, A., Ivanov, D., Peter, B., Berger, D., Stefanzl, G., Bauer, K., Slavnitsch, K., Greiner, G., Gleixner, K. V., Sperr, W. R., Willmann, M., Sill, H., Bettelheim, P., Geissler, K., Deininger, M., Rülicke, T., & Valent, P. (2021). Phenotypic characterization of leukemia-initiating stem cells in chronic myelomonocytic leukemia. Leukemia, 1–12. https://doi.org/10.1038/s41375-021-01227-z Cite
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Identification and Characterization of a Subpopulation of CD133+ Cancer Stem-Like Cells Derived from SK-UT-1 Cells

Scientists characterized and identify a subpopulation of CD133+ cancer stem-like cells derived from SK-UT-1 cell line.
[Cancer Cell International]
Gao, J., Yang, T., Wang, X., Zhang, Y., Wang, J., Zhang, B., Tang, D., Liu, Y., Gao, T., Lin, Q., Tang, J., & Cai, J. (2021). Identification and characterization of a subpopulation of CD133+ cancer stem‐like cells derived from SK-UT-1 cells. Cancer Cell International, 21(1), 157. https://doi.org/10.1186/s12935-021-01817-y Cite
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Simultaneously Target of Normal and Stem Cells-Like Gastric Cancer Cells via Cisplatin and Anti-CD133 CAR-T Combination Therapy

Cisplatin and anti-CD133 chimeric antigen receptor T (CAR-T) combination treatment inhibited tumor progression in three different xenograft models with diminished CD133 positive stem cell-like cell infiltration.
[Cancer Immunology Immunotherapy]
Han, Y., Sun, B., Cai, H., & Xuan, Y. (2021). Simultaneously target of normal and stem cells-like gastric cancer cells via cisplatin and anti-CD133 CAR-T combination therapy. Cancer Immunology, Immunotherapy. https://doi.org/10.1007/s00262-021-02891-x Cite
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Inhibition of Bruton’s Tyrosine Kinase as a Therapeutic Strategy for Chemoresistant Oral Squamous Cell Carcinoma and Potential Suppression of Cancer Stemness

Researchers investigated the effects of Bruton’s tyrosine kinase (BTK) on oncurrent chemoradiotherapy-resistant oral squamous cell carcinoma tissues (OSCC). The effect of ibrutinib, a first-in-class BTK inhibitor, was tested on stem cell-like OSCC tumorspheres.
[Oncogenesis]
Liu, S.-C., Wu, Y.-C., Huang, C.-M., Hsieh, M.-S., Huang, T.-Y., Huang, C.-S., Hsu, T.-N., Huang, M.-S., Lee, W.-H., Yeh, C.-T., & Lin, C.-S. (2021). Inhibition of Bruton’s tyrosine kinase as a therapeutic strategy for chemoresistant oral squamous cell carcinoma and potential suppression of cancer stemness. Oncogenesis, 10(2), 1–18. https://doi.org/10.1038/s41389-021-00308-z Cite
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The Combination Effect of Prominin1 (CD133) Suppression and Oxaliplatin Treatment in Colorectal Cancer Therapy

Scientists checked the combined effect of CD133 siRNA and Oxaliplatin on proliferation, migration, apoptosis, and stemness properties of olorectal cancer cells in the HT-29 cell line.
[Biomedicine & Pharmacotherapy]
Asadzadeh, Z., Mansoori, B., Mohammadi, A., Kazemi, T., Mokhtarzadeh, A., Shanehbandi, D., Hemmat, N., Derakhshani, A., Brunetti, O., Safaei, S., Aghajani, M., Najafi, S., Silvestris, N., & Baradaran, B. (2021). The combination effect of Prominin1 (CD133) suppression and Oxaliplatin treatment in colorectal cancer therapy. Biomedicine & Pharmacotherapy, 137, 111364. https://doi.org/10.1016/j.biopha.2021.111364 Cite
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Regulatory T Cells Promote Glioma Cell Stemness through TGF-β–NF-κB–IL6–STAT3 Signaling

Mechanistic investigations indicated that TGF-β acted on cancer cells to induce the core cancer stem cell-related genes CD133, SOX2, NESTIN, MUSASHI1 and ALDH1A expression and spheres formation via NF-κB–IL6–STAT3 signaling pathway, resulting in the increased cancer stemness and tumorigenic potential.
[Cancer Immunology Immunotherapy]
Regulatory T cells promote glioma cell stemness through TGF-β–NF-κB–IL6–STAT3 signaling | SpringerLink. (n.d.). Retrieved February 17, 2021, from https://link.springer.com/article/10.1007%2Fs00262-021-02872-0 Cite
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IL-6 and IL-8, Secreted by Myofibroblasts in the Tumor Microenvironment, Activate HES1 to Expand the Cancer Stem Cell Population in Early Colorectal Tumor

Scientists investigated the cancer stem cell‐promoting effect of factors released from myofibroblasts into the microenvironment of early colorectal cancer tumors and its molecular mechanism.
[Molecular Carcinogenesis]
Kim, B., Seo, Y., Kwon, J.-H., Shin, Y., Kim, S., Park, S. J., Park, J. J., Cheon, J. H., Kim, W. H., & Kim, T. I. (n.d.). IL-6 and IL-8, secreted by myofibroblasts in the tumor microenvironment, activate HES1 to expand the cancer stem cell population in early colorectal tumor. Molecular Carcinogenesis, n/a(n/a). https://doi.org/https://doi.org/10.1002/mc.23283 Cite
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