Melatonin Is a Potential Oncostatic Agent to Inhibit HepG2 Cell Proliferation through Multiple Pathways

Researchers investigated melatonin’s antitumor molecular mechanisms to inhibit the proliferation of HepG2 cells.
[Heliyon]
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Identification and Functional Characterization of CD133+GFAP+CD117+Sca1+ Neural Stem Cells

C57BL/6 mice were used to isolate and identify CD133+GFAP+CD117+Sca1+ cells in the hippocampal dentate gyrus region of the mouse brain as a novel neural stem cell population, in terms of cell phenotype, self-renewal capacity, and differentiation capability.
[Molecular and Cellular Biochemistry]
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Notch Pathway Inhibition Mediated by Arsenic Trioxide Depletes Tumor Initiating Cells in Small Cell Lung Cancer

Researchers demonstrated that As2O3 had a remarkable inhibitory effect on tumor initiating cells of small cell lung cancer both in vitro and in vivo, and the mechanism might have involved the down-regulation of Notch pathway
[Molecular Biology Reports]
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Emerging Roles of CD133 in the Treatment of Gastric Cancer, a Novel Stem Cell Biomarker and Beyond

Scientists summarize the current knowledge of the role of CD133 expression in gastic cancer and aim to contribute at identifying promising new strategies for treatment and management of gastric cancer.
[Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences]
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Induction of Cancer Cell Stemness in Glioma through Glycolysis and the Long Noncoding RNA HULC-Activated FOXM1/AGR2/HIF-1α Axis

Brain tissues were clinically collected from 50 patients with glioblastoma and 35 patients with acute craniocerebral injury, followed by immunohistochemical detection of the expression patterns of Forkhead box M1, anterior gradient 2, and hypoxia-inducible factor-1α.
[Laboratory Investigation]
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Functional Assessment of miR-1291 in Colon Cancer Cells

The expression and effect of miR‑1291 in colorectal cancer cells (CRC) was investigated. It was identified that miR‑1291 significantly suppressed the proliferation, invasion, cell mobility and colony formation of CRC cells.
[International Journal of Oncology]
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Metformin Promotes the Hair-Inductive Activity of Three-Dimensional Aggregates of Epidermal and Dermal Cells Self-Assembled In Vitro

Scientists assessed the effect of metformin on hair growth in a mouse hair follicle reconstitution model generated by in vitro self-assembled 3D aggregates of epidermal and dermal cells and suggested that metformin could promote hair follicle regeneration through up-regulation of the hair inductive capability of dermal cells.
[Skin Pharmacology and Physiology]
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Phenotyping Clonal Populations of Glioma Stem Cell Reveals a High Degree of Plasticity in Response to Changes of Microenvironment

Investigators used a barcode labelling approach of glioma-initiating cells to generate clonal populations over a number of passages, in combination with phenotyping using the established stem cell markers CD133, CD15, CD44, and A2B5.
[Laboratory Investigation]
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miR-126 in Extracellular Vesicles Derived from Hepatoblastoma Cells Promotes the Tumorigenesis of Hepatoblastoma through Inducing the Differentiation of BMSCs into Cancer Stem Cells

Scientists explored the differentially expressed miRNAs related to tumor cell-derived extracellular vesciles (EVs) and the mechanism by which EVs regulated hepatoblastoma progression.
[Journal of Immunology Research]
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Hypoxia Preconditioned Mesenchymal Stem Cell-Derived Exosomes Induce Ex Vivo Expansion of Umbilical Cord Blood Hematopoietic Stem Cells CD133+ by Stimulation of Notch Signalling Pathway

Scientists examined the importance of hypoxia-preconditioned mesenchymal stem cells-derived exosomes and normoxia-preconditioned MSC-derived exosomes in the self-renewal and long-term clonogenic potential of umbilical cord blood hematopoietic stem cells.
[Biotechnology Progress]
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MYH9 Is Crucial for Stem Cell-Like Properties in Non-Small Cell Lung Cancer by Activating mTOR Signaling

The authors found that the stemness characteristics of lung cancer cells were significantly enhanced by the overexpression of non-muscle myosin heavy chain 9 (MYH9), and the knockout of MYH9 had the opposite effects.
[Cell Death Discovery]
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