Hypoxia Induces an Endometrial Cancer Stem-Like Cell Phenotype via HIF-Dependent Demethylation of SOX2 mRNA

Scientists investigated the regulatory mechanisms regulated by hypoxia-inducing factors (HIFs) and SOX2 in endometrial cancer stem cells (ECSCs) during endometrial cancer (EC) development. ECSCs isolated from EC cell lines and tissues were found to express stemness genes.
[Oncogenesis]
Chen, G., Liu, B., Yin, S., Li, S., Guo, Y., Wang, M., Wang, K., & Wan, X. (2020). Hypoxia induces an endometrial cancer stem-like cell phenotype via HIF-dependent demethylation of SOX2 mRNA. Oncogenesis, 9(9), 1–14. https://doi.org/10.1038/s41389-020-00265-z Cite
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Characteristics of CD133-Sustained Chemoresistant Cancer Stem-Like Cells in Human Ovarian Carcinoma

Researchers investigated changes in expression levels of the cancer stem cell (CSC) biomarker, cluster of differentiation 133 (CD133), from primary ovarian cancer (OC) cell lines to induction of CSC-spheres in an attempt to explore the mechanisms related to modulation of stemness, drug resistance, and tumorigenesis in CSCs, thus facilitating the search for new therapeutics for OC.
[International Journal of Molecular Sciences]
Liu, C. L., Chen, Y. J., Fan, M. H., Liao, Y. J., & Mao, T. L. (2020). Characteristics of CD133-Sustained Chemoresistant Cancer Stem-Like Cells in Human Ovarian Carcinoma. International Journal of Molecular Sciences, 21(18), 6467. https://doi.org/10.3390/ijms21186467 Cite
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SMOC2, an Intestinal Stem Cell Marker, Is an Independent Prognostic Marker Associated with Better Survival in Colorectal Cancers

Investigators showed that SPARC-related modular calcium-binding protein 2 transcript level was higher in colorectal cancer samples than in normal mucosa; this level was not associated with candidate cancer stem cell markers or intestinal stem cell markers except for OLFM4.
[Scientific Reports]
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SMOC2, an Intestinal Stem Cell Marker, Is an Independent Prognostic Marker Associated with Better Survival in Colorectal Cancers

Researchers showed that SPARC-related modular calcium-binding protein 2 (SMOC2) transcript level was higher in colorectal cancer samples than in normal mucosa; this level was not associated with candidate cancer stem cell markers or intestinal stem cell markers except for OLFM4.
[Scientific Reports]
Jang, B. G., Kim, H. S., Bae, J. M., Kim, W. H., Kim, H. U., & Kang, G. H. (2020). SMOC2, an intestinal stem cell marker, is an independent prognostic marker associated with better survival in colorectal cancers. Scientific Reports, 10(1), 14591. https://doi.org/10.1038/s41598-020-71643-1 Cite
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Prevention of Akt Phosphorylation Is a Key to Targeting Cancer Stem-Like Cells by mTOR Inhibition

Scientists established a CD133+ cell-rich subline from Capan-1 pancreatic cancer cells as a pancreatic cancer stem cell model and compared the effects of KU-0063794, a dual mTORC1/mTORC2 inhibitor, against those of mTORC1-specific rapamycin.
[Human Cell]
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1,25-Dihydroxyvitamin D3 Signaling-Induced Decreases in IRX4 Inhibits NANOG-Mediated Cancer Stem-Like Properties and Gefitinib Resistance in NSCLC Cells

Researchers discovered that increased iroquois-class homeodomain protein 4 (IRX4) was related to gefitinib resistance in non-small cell lung cancer (NSCLC) cells. Knockdown of IRX4 inhibited cell proliferation, sphere formation, and the expression of CD133, ALDH1A1, NANOG, Sox2 and Notch1, and the transcriptional activity of NANOG promoter.
[Cell Death & Disease]
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Circulating Endothelial Progenitor Cells during Pregnancy in Multiple Sclerosis

CD34+ and CD133+ were longitudinally detected by flow cytometry in the maternal plasma of 29 healthy controls and nine multiple sclerosis patients and in the cord blood of their newborns.
[Neurological Sciences]
Mallucci, G., Beneventi, F., Bergamaschi, R., Bizzotto, C., Cavagnoli, C., De Maggio, I., Bellingeri, C., Monti, C., Viarengo, G., & Spinillo, A. (2020). Circulating endothelial progenitor cells during pregnancy in multiple sclerosis. Neurological Sciences. https://doi.org/10.1007/s10072-020-04648-3 Cite
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Intracoronary Injection of Hematopoietic Precursor Cells Regenerates the Borders, but Not the Core, of Old Myocardial Scars

The authors studied function recovery at the scar zone and its impact in global left ventricular function after intracoronary injection of hematopoietic precursor cells.
[ESC Heart Failure]
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Identification of a Subpopulation of Long-Term Tumor-Initiating Cells in Colon Cancer

Based on the methods for isolating and identifying cancer stem cells and the functional features of long-term tumor-initiating cells (LT-TICs), the authors aimed to identify a subpopulation of LT-TICs.
[Bioscience Reports]
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A New Protocol for Long‐Term Culture of a Specific Subpopulation of Liver Cancer Stem Cells Enriched by Cell Surface Markers

Scientists provide a new in vitro long‐term culture model for a specific subpopulation of liver cancer stem cells enriched by cell surface markers.
[Febs Open Bio]
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