CD133

[Cell Reports] Researchers reported that Ewing sarcoma cells were dependent on the autocrine signaling mediated by NELL2, a secreted glycoprotein that has been characterized as an axon guidance molecule.

[Molecular Medicine Reports] M2‑like tumor‑associated macrophages (TAMs) accelerated the metastasis and increased the stemness of anaplastic thyroid carcinoma cells, and the underlying mechanism may have been related to the section of insulin‑like growth factor by M2‑like TAMs, which activated the IR‑A/IGF1R‑mediated PI3K/AKT/mTOR signaling pathway.

[Oncogene] Investigators demonstrated that ZEB2, the transcription factor of epithelial–mesenchymal transition, was upregulated in ascites cells from high-grade serous ovarian cancer patients and in CD133+ cancer stem-like cells from epithelial ovarian cancer cell lines.

[Nutrition and Cancer-An International Journal] Scientists evaluated the effects of Bryophytes like Abietinella abietina, Homolothecium sericeum, Tortella tortuosa, Syntrichia ruralis, and Bryoerythrophyllum rubrum species extracted with ethyl alcohol on 5-fluorouracil resistant colorectal cancer cell lines.

[Molecular Therapy-Oncolytics] Researchers hypothesized that by creating an MHC independent vaccination, they would give rise to a sustained immune response against CD133 in triple negative breast carcinomas.

[Nature Communications] Scientists used 4T1 mammary tumor cells to validate the contribution of the human ribonuclease 1–tyrosine kinase receptor ephrin A4 axis to breast tumorigenicity.