CD8

[Nature Cell Biology] The authors reported that cancer cells with aberrant expression of glutamate decarboxylase 1 rewired glutamine metabolism for the synthesis of γ-aminobutyric acid (GABA)—a prominent neurotransmitter—in non-nervous tissues.

[JCI Insight] Scientists examined the spatial localization, phenotype, and function of CD8+ T cells in the human duodenal tissue from people living with HIV and healthy controls.

[Science Advances] Investigators found that T cell–specific deletion of nuclear helicase Dhx9 led to impaired CD8+ T cell survival, effector differentiation, and viral clearance.

[PLoS Pathogens] Researchers investigated whether infusion of T cells expressing an simian immunodeficiency virus-specific chimeric antigen receptor and the follicular homing receptor, CXCR5, could successfully kill viral-RNA+ cells in targeted lymphoid follicles in SIV-infected rhesus macaques.

[Science] By mapping 55 neoantigen-specific TCR clonotypes from 10 metastatic human tumors to their single-cell transcriptomes, scientists identified signatures of CD8+ and CD4+ neoantigen-reactive tumor-infiltrating lymphocytes.

[Science Immunology] Scientists studied neutralizing antibodies and T-cell responses targeting SARS-CoV-2 D614G (wildtype), and Beta, Delta, and Omicron variants of concern in a cohort of 60 health care workers after immunization with ChAdOx-1 S, Ad26.COV2.S, mRNA-1273 or BNT162b2.