EGFR

[Cancer Research] Using genetically defined models, researchers showed that HDAC2 was a cellular fitness factor that controls cell cycle in vitro and metastasis in vivo, particularly in undifferentiated, mesenchymal pancreatic ductal adenocarcinoma cells.

[Communications Biology] Researchers presented a small-molecule compound D6 which selectively inhibited tumor cell growth and migration in NSCLC cells with EGFR-TKI-resistant T790M-EGFR-activated mutations.

[Military Medical Research] Researchers evaluated the antitumor activities of LR004-VC-MMAE against epidermal growth factor receptor (EGFR)-positive TNBC and further studied its possible mechanism of antitumor action.

[Experimental & Molecular Medicine] The authors reported that BIX01294 (BIX) induced apoptotic cell death in EGFR-mutant NSCLC cells but not in their wild-type counterparts. Treatment with BIX resulted in a significant reduction in the EGFR level and inhibition of EGFR signaling only in EGFR-mutant NSCLC cells, leading to apoptosis.

[Journal of Biological Chemistry] Scientists examined for the first time the effect of N-myc-downregulated gene 1 (NDRG1) on androgen receptor expression, activation, and downstream signaling in LNCaP, 22Rv1 and C4-2B prostate cancer cell types.

[Laboratory Investigation] Scientists explored the protective effect of vitamin E on chronic obstructive pulmonary disease and the underlying mechanisms.