EMT

[FEBS Journal] The authors discuss cancer-type specific molecular targets, context-dependent mechanisms and future directions of research in targeting EHMT1/EHMT2 for the treatment of cancer.

[Cancer Biology & Therapy] C-Myc overexpression is a common finding in pancreatic cancer and predicts the aggressive behavior of cancer cells. It binds to the promoter of different genes, thereby regulating their transcription.

[Cell Death & Disease] The authors identified a novel long non-coding RNA KDM4A-AS1, which was aberrantly overexpressed in hepatocellular carcinoma (HCC) tissues, associated with unfavorable clinical features and poor prognosis of patients. KDM4A-AS1 promoted HCC cell proliferation, migration, and invasion in vitro and contributed to HCC growth and lung metastasis in vivo.

[Cell Death Discovery] Researchers explored the potential functions of hypoxia-induced upregulation of Fascin-1 in liver cancer and found that Fascin-1 was upregulated by hypoxia in liver cancer cell lines, elevated in liver cancer patients and correlated with larger tumor size, lymph node metastasis, distant metastasis, and shorter overall survival.

[Molecular Cancer Research] Scientists demonstrated that overexpression of G protein–coupled receptors implicated in breast cancer pathogenesis, specifically the receptors for Angiotensin II and thrombin, drove a strong epithelial-to-mesenchymal transition program in breast cancer cells that was characteristic of claudin-low, TNBC.

[Cancer Cell International] Investigators characterized the function of eukaryotic translation initiation factors (eIFs) in epithelial-mesenchymal-transition (EMT) and metastasis in pancreatic cancer cells to investigate whether eIFs and downstream c-MYC affect EMT and metastasis by joint interference.