MALT1 Is a Targetable Driver of Epithelial-to-Mesenchymal Transition in Claudin-Low, Triple-Negative Breast Cancer

Scientists demonstrated that overexpression of G protein–coupled receptors implicated in breast cancer pathogenesis, specifically the receptors for Angiotensin II and thrombin, drove a strong epithelial-to-mesenchymal transition program in breast cancer cells that was characteristic of claudin-low, TNBC.