Targeting CLK4 Inhibits the Metastasis and Progression of Breast Cancer by Inactivating TGF-β Pathway

Scientists investigated the potential involvement of CLK4 in the metastasis and progression of mesenchymal-like (MES-) TNBC. In the MES-TNBC cell lines, the CLK4 expression was elevated.
[Cancer Gene Therapy]
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Autophagy Inhibits Cancer Stemness in Triple-Negative Breast Cancer via miR-181a-Mediated Regulation of ATG5 and/or ATG2B

The authors identified that autophagy flux was inhibited in triple-negative breast cancer (TNBC) stem cells. miRNA-181a (miR-181a) expression is upregulated both in TNBC CSCs and patient tissues.
[Molecular Oncology]
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C/EBPβ Isoform-Specific Regulation of Migration and Invasion in Triple-Negative Breast Cancer Cells

Scientists showed that reverting the high LIP/LAP ratios in TNBC cell lines into low LIP/LAP ratios by overexpression of LAP reduced migration and matrix invasion of these TNBC cells.
[npj Breast Cancer]
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Rubius Therapeutics Announces Dosing of First Patient in Phase I/II Trial of RTX-224, a Broad Immune Agonist, for the Treatment of Certain Solid Tumors

Rubius Therapeutics, Inc. announced that the first patient has been dosed in its Phase I/II clinical trial of RTX-224 for the treatment of patients with certain relapsed/refractory or locally advanced solid tumors, including non-small cell lung cancer, cutaneous melanoma, head and neck squamous cell carcinoma, urothelia carcinoma and triple-negative breast cancer.
[Rubius Therapeutics, Inc.]
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MUC1-C Dictates JUN and BAF-Mediated Chromatin Remodeling at Enhancer Signatures in Cancer Stem Cells

The authors demonstrated that MUC1-C drove global changes in chromatin architecture in the dedifferentiation of CRPC and triple-negative breast cancer cells.
[Molecular Cancer Research]
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RNA-Binding Protein p54nrb/NONO Potentiates Nuclear EGFR-Mediated Tumorigenesis of Triple-Negative Breast Cancer

Scientists indicated that NONO enhanced nuclear epidermal growth factor receptor (EGFR)-mediated tumorigenesis and may be a potential therapeutic target for TNBC patients with nuclear EGFR expression.
[Cell Death & Disease]
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Targeting Prooxidant MnSOD Effect Inhibits Triple-Negative Breast Cancer (TNBC) Progression and M2 Macrophage Functions under the Oncogenic Stress

Knockdown of MnSOD inhibited TNBC cell invasion, breast cancer stem cells, mitochondrial reactive oxygen species, and interleukin-6 excretion promoted by multiple copies in T cell malignancy-1.
[Cell Death & Disease]
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Endoplasmic Reticulum Stress Inhibits AR Expression via the PERK/eIF2α/ATF4 Pathway in Luminal Androgen Receptor Triple-Negative Breast Cancer and Prostate Cancer

Investigators demonstrated that endoplasmic reticulum stress could decrease androgen receptor mRNA and protein levels via PERK/eIF2α/ATF4 signaling in luminal androgen receptor TNBC and prostate cancer.
[npj Breast Cancer]
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KDM6A Depletion in Breast Epithelial Cells Leads to Reduced Sensitivity to Anticancer Agents and Increased TGF-β Activity

Using MCF10A as a model of non-tumorigenic epithelial breast cells, scientists found that silencing KDM6A promoted cell migration and transformation demonstrated by the formation of tumor-like acini in three-dimensional culture.
[Molecular Cancer Research]
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Regulatory T Cells: Their Role in Triple-Negative Breast Cancer Progression and Metastasis

Researchers review the role of tumor-infiltrating Tregs in tumor progression and metabolic reprogramming of the tumor microenvironment.
[Cancer]
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Neoadjuvant STING Activation, Extended Half-life IL2, and Checkpoint Blockade Promote Metastasis Clearance via Sustained NK-Cell Activation

Investigators combined intratumoral STimulator of INterferon Genes (STING) agonist therapy with systemically injected extended half-life IL2 and anti–PD-1 checkpoint blockade to drive innate and adaptive antitumor immunity in models of triple-negative breast cancer.
[Cancer Immunology Research]
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