Roche Provides Update on Phase III Study of Tecentriq in Combination with Paclitaxel for People with Metastatic Triple-Negative Breast Cancer

Roche announced that the Phase III IMpassion131 study, evaluating Tecentriq® in combination with paclitaxel, in comparison to placebo plus paclitaxel, did not meet statistical significance on its primary endpoint of progression-free survival for the initial treatment of people with metastatic triple-negative breast cancer, in the PD-L1-positive population.
[Roche]
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Effects of Cancer Stem Cells in Triple-Negative Breast Cancer and Brain Metastasis: Challenges and Solutions

Researchers summarized recent literature regarding molecules and pathways and reviewed the effects of cancer stem cells biology during the formation of brain metastasis in TNBC.
[Cancers]
Lee, K.-L., Chen, G., Chen, T.-Y., Kuo, Y.-C., & Su, Y.-K. (2020). Effects of Cancer Stem Cells in Triple-Negative Breast Cancer and Brain Metastasis: Challenges and Solutions. Cancers, 12(8), 2122. https://doi.org/10.3390/cancers12082122 Cite
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Rosmarinic Acid-Induced Apoptosis and Cell Cycle Arrest in Triple-Negative Breast Cancer Cells

Researchers evaluated the effects and mechanisms of rosmarinic acid (RA) in two racially different TNBC cell lines. Results obtained showed that RA significantly caused cytotoxic and antiproliferative effects in both cell lines in a dose- and time-dependent manner. RA induced cell cycle arrest-related apoptosis and altered the expression of many apoptosis-involved genes differently.
[European Journal of Pharmacology]
Messeha, S. S., Zarmouh, N. O., Asiri, A., & Soliman, K. F. A. (2020). Rosmarinic acid-induced apoptosis and cell cycle arrest in triple-negative breast cancer cells. European Journal of Pharmacology, 173419. https://doi.org/10.1016/j.ejphar.2020.173419 Cite
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Daiichi Sankyo and AstraZeneca Enter New Global Development and Commercialization Collaboration for Daiichi Sankyo’s ADC DS-1062

Daiichi Sankyo Company, Limited announced that it has entered into a global development and commercialization agreement with AstraZeneca for Daiichi Sankyo’s DS-1062, a TROP2 directed DXd antibody drug conjugate, currently in Phase I clinical development for non-small cell lung cancer and TNBC.
[Daiichi Sankyo Ltd.]
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Merck Announces Two US Regulatory Milestones for KEYTRUDA® (pembrolizumab) in Triple-Negative Breast Cancer (TNBC)

Merck announced that the FDA has accepted two new supplemental Biologics License Applications for KEYTRUDA, Merck’s anti-PD-1 therapy.
[Merck]
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Effects of Cancer Stem Cells in Triple-Negative Breast Cancer and Brain Metastasis: Challenges and Solutions

The authors summarize recent literature regarding molecules and pathways and reviewed the effects of cancer stem cell biology during the formation of brain metastasis in triple-negative breast cancer.
[Cancers]
Lee, K.-L., Chen, G., Chen, T.-Y., Kuo, Y.-C., & Su, Y.-K. (2020). Effects of Cancer Stem Cells in Triple-Negative Breast Cancer and Brain Metastasis: Challenges and Solutions. Cancers, 12(8), 2122. https://doi.org/10.3390/cancers12082122 Cite
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Spatiotemporal PET Imaging Reveals Differences in CAR-T Tumor Retention in Triple-Negative Breast Cancer Models

Researchers generated and characterized traceable CAR T cells and examined potential negative effects of radionuclide reporter use. They applied the platform to two different triple-negative breast cancer models and unexpectedly observed pronounced differences in CAR-T tumor retention by PET/computed tomography and confirmed data ex vivo.
[Molecular Therapy]
Volpe, A., Lang, C., Lim, L., Man, F., Kurtys, E., Ashmore-Harris, C., Johnson, P., Skourti, E., Rosales, R. T. M. de, & Fruhwirth, G. O. (2020). Spatiotemporal PET Imaging Reveals Differences in CAR-T Tumor Retention in Triple-Negative Breast Cancer Models. Molecular Therapy, 0(0). https://doi.org/10.1016/j.ymthe.2020.06.028 Cite
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Pyrvinium Pamoate Induces Death of Triple-Negative Breast Cancer Stem-Like Cells and Reduces Metastases through Effects on Lipid Anabolism

The authors investigated spheroid-forming cells in a metastatic triple-negative breast cancer model. This strategy enabled them to specifically study a population of long-lived tumor cells enriched in cancer stem-like cells, which showed stem-like characteristics and induce metastases.
[Cancer Research]
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Glycosphingolipid Expression at Breast Cancer Stem Cells after Novel Thieno[2,3-B]Pyridine Anticancer Compound Treatment

Scientists performed studies of viability, type of cell death, cancer stem cell percent and glycosphingolipid expression on CSC and non-CSC after treatment of MDA-MB-231 and MDA-MB-453 triple-negative breast cancer cells with a newly developed thienopyridine anticancer compound.
[Scientific Reports]
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LEFTY1 Is a Dual-SMAD Inhibitor that Promotes Mammary Progenitor Growth and Tumorigenesis

Scientists showed that LEFTY1, a secreted inhibitor of NODAL/SMAD2 signaling, was produced by mammary progenitor cells and, concomitantly, suppresses SMAD2 and SMAD5 signaling to promote long-term proliferation of normal and malignant mammary epithelial cells.
[Cell Stem Cell]
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Immunostimulatory and Anti-Tumor Metronomic Cyclophosphamide Regimens Assessed in Primary Orthotopic and Metastatic Murine Breast Cancer

Cyclophosphamide (CTX) increased expression of tumor cell PD-L1; however, when combined with concomitant PD-L1 antibody therapy none of the CTX regimens showed increased benefit.
[NPJ Breast Cancer]
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Aspirin Attenuates YAP and β-Catenin Expression by Promoting β-TrCP to Overcome Docetaxel and Vinorelbine Resistance in Triple-Negative Breast Cancer

Investigators demonstrated that changes in the expression of Yes-associated protein and β-catenin might be a promising predictive biomarker for neoadjuvant chemotherapy sensitivity in TNBC patients.
[Cell Death & Disease]
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