Characteristics and Spatially-Defined Immune (Micro)landscapes of Early-Stage PD-L1-Positive Triple-Negative Breast Cancer

A large cohort of chemotherapy-naïve triple-negative breast cancer (TNBC), clinicopathologic features, deconvoluted RNA immune signatures, and intraepithelial and stromal TIME were identified in subsets of PD-L1+ and PD-L1- TNBC.
[Clinical Cancer Research]
Carter, J. M., Polley, M.-Y. C., Leon-Ferre, R. A., Sinnwell, J., Thompson, K. J., Wang, X., Ma, Y., Zahrieh, D., Kachergus, J. M., Solanki, M., Boughey, J. C., Liu, M. C., Ingle, J. N., Kalari, K. R., Couch, F. J., Thompson, E. A., & Goetz, M. P. (2021). Characteristics and spatially-defined immune (micro)landscapes of early-stage PD-L1-positive triple-negative breast cancer. Clinical Cancer Research. https://doi.org/10.1158/1078-0432.CCR-21-0343 Cite
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Metabolic Perturbations Sensitize Triple-Negative Breast Cancers to Apoptosis Induced by BH3 Mimetics

The authors investigated the metabolic vulnerabilities of TNBC, particularly those metabolic perturbations that increased mitochondrial apoptotic priming and sensitivity to BH3 mimetics.
[Science Signaling]
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Long Noncoding RNAs in Triple-Negative Breast Cancer: A New Frontier in the Regulation of Tumorigenesis

The authors highlight the association of several long noncoding RNAs in TNBC progression and treatment, along with their possible functions and mechanisms.
[Journal of Cellular Physiology]
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Genetic Variation Associated with Thyroid Autoimmunity Shapes the Systemic Immune Response to PD-1 Checkpoint Blockade

The authors studied endocrine immune related adverse events from seven clinical trials across six cancers where atezolizumab was combined with chemotherapies and compared to standard of care.
[Nature Communications]
Khan, Z., Hammer, C., Carroll, J., Di Nucci, F., Acosta, S. L., Maiya, V., Bhangale, T., Hunkapiller, J., Mellman, I., Albert, M. L., McCarthy, M. I., & Chandler, G. S. (2021). Genetic variation associated with thyroid autoimmunity shapes the systemic immune response to PD-1 checkpoint blockade. Nature Communications, 12(1), 3355. https://doi.org/10.1038/s41467-021-23661-4 Cite
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Targeting the Tetraspanin CD81 Reduces Cancer Invasion and Metastasis

Scientists showed that a unique anti-human CD81 antibody (5A6) effectively halted invasion of TNBC cell lines. They demonstrated that 5A6 induced CD81 clustering at the cell membrane and implicated JAM-A protein in the ability of this antibody to inhibit tumor cell invasion and migration.
[Proceedings of the National Academy of Sciences of the United States of America]
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The LINC01119-SOCS5 Axis as a Critical Theranostic in Triple-Negative Breast Cancer

Mesenchymal stem/stromal cells stimulated robust expression of LINC01119 in TNBC cells, which in turn induced suppression of cytokine signaling 5 (SOCS5), leading to accelerated cancer cell growth and tumorigenesis.
[npj Breast Cancer]
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The Targetable Nanoparticle BAF312@cRGD-CaP-NP Represses Tumor Growth and Angiogenesis by Downregulating the S1PR1/P-STAT3/VEGFA Axis in Triple-Negative Breast Cancer

Researchers prepared shell-core structure nanoparticles which inhibited tumor growth and angiogenesis in vitro and in MDA-MB-231 tumor-bearing mice via downregulating the sphingosine 1 phosphate receptor 1/phosphorylated signal transducer and activator of transcription 3/vascular endothelial growth factor A axis.
[Journal of Nanobiotechnology]
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The LINC01119-SOCS5 Axis as a Critical Theranostic in Triple-Negative Breast Cancer

The authors focused on the emerging class of RNAs called long non-coding RNAs or lncRNAs and utilized a MSC-supported triple-negative breast cancer (TNBC) progression model to identify specific family members of functional relevance to TNBC pathogenesis.
[npj Breast Cancer]
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Syndecan-1 Depletion Has a Differential Impact on Hyaluronic Acid Metabolism and Tumor Cell Behavior in Luminal and Triple-Negative Breast Cancer Cells

Investigators studied the effect of syndecan-1 siRNA depletion and hyaluronic acid treatment on hallmark processes of cancer in breast cancer cell lines of different levels of aggressiveness.
[International Journal of Molecular Sciences]
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HDAC6 Inhibitors Sensitize Non-Mesenchymal Triple-Negative Breast Cancer Cells to Cysteine Deprivation

To overcome cysteine deprivation resistance in TNBC cells, scientists identified three selective HDAC6 inhibitors using epigenetic compound library screening and used them to induce cell death in the non-mesenchymal TNBC.
[Scientific Reports]
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INPP4B Promotes PI3Kα-Dependent Late Endosome Formation and Wnt/β-Catenin Signaling in Breast Cancer

Scientists found that PIK3CA-mutant ER+ breast cancers exhibited increased INPP4B mRNA and protein expression and INPP4B increased the proliferation and tumor growth of PIK3CA-mutant ER+ breast cancer cells, despite suppression of AKT signaling.
[Nature Communications]
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