IKBKE Phosphorylates and Stabilizes Snail to Promote Breast Cancer Invasion and Metastasis

Researchers revealed a novel oncogenic function of IKBKE in promoting breast cancer metastasis by governing Snail abundance, and highlighted the potential of targeting IKBKE for metastatic breast cancer therapies.
[Cell Death & Differentiation]
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Role of Nischarin in the Pathology of Diseases: A Special Emphasis on Breast Cancer

The authors report the prognostic value, clinical relevance, and biological significance of the Nischarin gene in breast cancer patients using the Molecular Taxonomy of Breast Cancer International Consortium and The Cancer Genome Atlas datasets.
[Oncogene]
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The EMT-Induced lncRNA NR2F1-AS1 Positively Modulates NR2F1 Expression and Drives Gastric Cancer via miR-29a-3p/VAMP7 Axis

NR2F1-AS1 and NR2F1 were highly co-expressed in pan-tissues and pan-cancers. Depletion of NR2F1-AS1 compromised the expression level of NR2F1 in gastric cancer cells.
[Cell Death & Disease]
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Breast Cancer Circulating Tumor Cells with Mesenchymal Features — an Unreachable Target?

The authors review the clinical significance of mesenchymal circulating tumor cells (CTCs) in breast cancer together with statistical analysis of previously published data, in which they assess the suitability of a number of methods/markers used for isolation of CTCs with different epithelial-mesenchymal transition phenotypes.
[Cellular and Molecular Life Sciences]
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Nogo-B Promotes Invasion and Metastasis of Nasopharyngeal Carcinoma via RhoA-SRF-MRTFA Pathway

Scientists found that higher expression of neurite outgrowth inhibitor B (Nogo-B) was detected in nasopharyngeal carcinoma (NPC) cells and tissues. Higher expression of Nogo-B was statistically relevant to N stage, M stage, and poor prognosis in NPC patients.
[Cell Death & Disease]
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Canonical TGFβ Signaling Induces Collective Invasion in Colorectal Carcinogenesis through a Snail1- and Zeb1-Independent Partial EMT

The authors investigated the impact of oncogenic transformation and the microenvironment on tumor cell invasion using genetically engineered organoids as colorectal cancer models.
[Oncogene]
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HERC3 Regulates Epithelial-Mesenchymal Transition by Directly Ubiquitination Degradation EIF5A2 and Inhibits Metastasis of Colorectal Cancer

HERC3 was indicated to inhibit the migration, invasion and metastasis in vitro and in vivo through transwell assays, wound healing assays and vivo experiments.
[Cell Death & Disease]
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Targeting CLK4 Inhibits the Metastasis and Progression of Breast Cancer by Inactivating TGF-β Pathway

Scientists investigated the potential involvement of CLK4 in the metastasis and progression of mesenchymal-like (MES-) TNBC. In the MES-TNBC cell lines, the CLK4 expression was elevated.
[Cancer Gene Therapy]
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C/EBPβ Isoform-Specific Regulation of Migration and Invasion in Triple-Negative Breast Cancer Cells

Scientists showed that reverting the high LIP/LAP ratios in TNBC cell lines into low LIP/LAP ratios by overexpression of LAP reduced migration and matrix invasion of these TNBC cells.
[npj Breast Cancer]
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POLE2 Facilitates the Malignant Phenotypes of Glioblastoma through Promoting AURKA-Mediated Stabilization of FOXM1

The authors revealed crucial roles and a novel mechanism of poly ε-B subunit (POLE2) involved in glioblastoma (GBM) through Aurora kinase A (AURKA)-mediated stability of forkhead transcription factor (FOXM1) and may provide the theoretical basis of molecular therapy for GBM.
[Cell Death & Disease]
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Loss of Circadian Gene Timeless Induces EMT and Tumor Progression in Colorectal Cancer via Zeb1-Dependent Mechanism

Genome-wide expression profiling, in vitro and in vivo experiments, revealed that Timeless knockdown induced the activation of the epithelial-to-mesenchymal transition program.
[Cell Death & Differentiation]
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