Tag Archives: EMT

Escherichia coli Foster Bladder Cancer Cell Line Progression via Epithelial Mesenchymal Transition, Stemness and Metabolic Reprogramming

In vitro infection of the T24 cell line with E. coli was performed to study the bacterial impact on bladder cancer cells. EMT markers were assessed using immunohistochemistry, western blot and RT-PCR. Stemness characteristics were monitored using RT-PCR.
[Scientific Reports]
Abd-El-Raouf, R., Ouf, S. A., Gabr, M. M., Zakaria, M. M., El-Yasergy, K. F., & Ali-El-Dein, B. (2020). Escherichia coli foster bladder cancer cell line progression via epithelial mesenchymal transition, stemness and metabolic reprogramming. Scientific Reports, 10(1), 18024. https://doi.org/10.1038/s41598-020-74390-5 Cite
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Epigenetic Silencing of ZIC4 Contributes to Cancer Progression in Hepatocellular Carcinoma

Functionally, zic family member 4 (ZIC4) inhibition facilitated the proliferation, migration, invasion, and epithelial-mesenchymal transition in vitro and in vivo. Conversely, ZIC4 overexpression reduced proliferation and invasiveness of hepatoceullar carcinoma cells.
[Cell Death & Disease]
Chen, W., Tang, D., Tang, D., & Dai, Y. (2020). Epigenetic silencing of ZIC4 contributes to cancer progression in hepatocellular carcinoma. Cell Death & Disease, 11(10), 1–11. https://doi.org/10.1038/s41419-020-03109-1 Cite
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Neddylation Blockade Induces HIF-1α Driven Cancer Cell Migration via Upregulation of ZEB1

Scientists report that inhibiting neddylation activates the hypoxia-inducible factor 1α (HIF-1α) through the PI3K-Akt pathway, which eventually regulates the epithelial to mesenchymal transition-activator zinc finger E-box binding homeobox 1 (ZEB1) in various cancer cell lines.
[Scientific Reports]
Park, J. B., Seo, J., Park, J.-W., & Chun, Y.-S. (2020). Neddylation blockade induces HIF-1α driven cancer cell migration via upregulation of ZEB1. Scientific Reports, 10(1), 18210. https://doi.org/10.1038/s41598-020-75286-0 Cite
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Rosuvastatin Inhibit Spheroid Formation and Epithelial-Mesenchymal Transition (EMT) in Prostate Cancer PC-3 Cell Line

PC-3 cells were cultured in adherence and/or spheroid culture system. The cells were treated with different concentrations of Rosuvastatin. After 96 hours, the cell proliferation, viability, type and number of spheroids, the expression of E-Cadherin, Vimentin and Zeb-1 were analyzed.
[Molecular Biology Reports]
Deezagi, A., & Safari, N. (2020). Rosuvastatin inhibit spheroid formation and epithelial–mesenchymal transition (EMT) in prostate cancer PC-3 cell line. Molecular Biology Reports. https://doi.org/10.1007/s11033-020-05918-1 Cite
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Identification of Drivers of Breast Cancer Invasion by Secretome Analysis: Insight Into CTGF Signaling

Scientists combined data from secretome and proteome analysis using mass spectrometry with microarray data from mesenchymal transformed breast cancer cells to elucidate the drivers of epithelial-mesenchymal transition and cell invasion.
[Scientific Reports]
Identification of drivers of breast cancer invasion by secretome analysis: insight into CTGF signaling | Scientific Reports. (n.d.). Retrieved October 21, 2020, from https://www.nature.com/articles/s41598-020-74838-8 Cite
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SCLC-CellMiner: A Resource for Small Cell Lung Cancer Cell Line Genomics and Pharmacology Based on Genomic Signatures

The authors demonstrated the reproducibility and stability of data from multiple sources and validate the small cell lung cancer (SCLC) consensus nomenclature on the basis of expression of master transcription factors NEUROD1, ASCL1, POU2F3, and YAP1.
[Cell Reports]
Tlemsani, C., Pongor, L., Elloumi, F., Girard, L., Huffman, K. E., Roper, N., Varma, S., Luna, A., Rajapakse, V. N., Sebastian, R., Kohn, K. W., Krushkal, J., Aladjem, M. I., Teicher, B. A., Meltzer, P. S., Reinhold, W. C., Minna, J. D., Thomas, A., & Pommier, Y. (2020). SCLC-CellMiner: A Resource for Small Cell Lung Cancer Cell Line Genomics and Pharmacology Based on Genomic Signatures. Cell Reports, 33(3). https://doi.org/10.1016/j.celrep.2020.108296 Cite
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Oncogenic KRAS-Expressing Organoids with Biliary Epithelial Stem Cell Properties Give Rise to Biliary Tract Cancer in Mice

Researchers isolated epithelial cell adhesion molecule-positive biliary epithelial cells from the mouse intrahepatic bile duct, gallbladder, and extrahepatic bile duct and established organoids derived from these cells.
[Cancer Science]
Kasuga, A., Semba, T., Sato, R., Nobusue, H., Sugihara, E., Takaishi, H., Kanai, T., Saya, H., & Arima, Y. (n.d.). Oncogenic KRAS–expressing organoids with biliary epithelial stem cell properties give rise to biliary tract cancer in mice. Cancer Science, n/a(n/a). https://doi.org/10.1111/cas.14703 Cite
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CHIP-Mediated CIB1 Ubiquitination Regulated Epithelial–Mesenchymal Transition and Tumor Metastasis in Lung Adenocarcinoma

The expression levels of CIB1 in lung adenocarcinoma tissues and adjacent normal tissues were examined by immunohistochemistry, and the relationship between CIB1 expression and patient clinicopathological characteristics was analyzed.
[Cell Death & Differentiation]
Liu, Y., Zhou, Y., Zhang, P., Li, X., Duan, C., & Zhang, C. (2020). CHIP-mediated CIB1 ubiquitination regulated epithelial–mesenchymal transition and tumor metastasis in lung adenocarcinoma. Cell Death & Differentiation, 1–15. https://doi.org/10.1038/s41418-020-00635-5 Cite
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PDSS2-Del2, a New Variant of PDSS2, Promotes Tumor Cell Metastasis and Angiogenesis in Hepatocellular Carcinoma via Activating NF-κB

PDSS2‐Del2 levels correlated significantly with microvessel counts in hepatocellular carcinoma (HCC) tumor tissues. Importantly, PDSS2‐Del2 overexpression functionally promoted HCC metastasis as demonstrated by in vitro and in vivo migration assays.
[Molecular Oncology]
Zeng, T., Tang, Z., Liang, L., Suo, D., Li, L., Li, J., Yuan, Y., Guan, X.-Y., & Li, Y. (n.d.). PDSS2-Del2, a new variant of PDSS2, promotes tumor cell metastasis and angiogenesis in hepatocellular carcinoma via activating NF-κB. Molecular Oncology, n/a(n/a). https://doi.org/10.1002/1878-0261.12826 Cite
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LncRNA SNHG10 Promotes the Proliferation and Invasion of Osteosarcoma via Wnt/β-Catenin Signaling

In vitro experiments (including colony formation, CCK-8, wound healing and transwell assays) and in vivo experiments indicated that down-regulation of SNHG10 significantly suppressed the proliferation and invasion of osteosarcoma cells
[Molecular Therapy-Nucleic Acids]
Zhu, S., Liu, Y., Wang, X., Wang, J., & Xi, G. (2020). LncRNA SNHG10 promotes the proliferation and invasion of osteosarcoma via Wnt/β-catenin signaling. Molecular Therapy - Nucleic Acids, 0(0). https://doi.org/10.1016/j.omtn.2020.10.010 Cite
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Mesenchymal Stem Cells Reverse EMT Process through Blocking the Activation of NF-κB and Hedgehog Pathways in LPS-Induced Acute Lung Injury

Researchers investigated the mechanism underneath MSC-reversed lung injury and fibrosis. They determined that coculture with MSC led to the inactivation of NF-κB signaling and therefore suppressed the hedgehog pathway in LPS-treated MLE-12 cells.
[Cell Death & Disease]
Xiao, K., He, W., Guan, W., Hou, F., Yan, P., Xu, J., Zhou, T., Liu, Y., & Xie, L. (2020). Mesenchymal stem cells reverse EMT process through blocking the activation of NF-κB and Hedgehog pathways in LPS-induced acute lung injury. Cell Death & Disease, 11(10), 1–17. https://doi.org/10.1038/s41419-020-03034-3 Cite
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