Tumor Immune Microenvironment during Epithelial-Mesenchymal Transition

Epithelial-mesenchymal transition (EMT) has been shown to play a critical role in tumor development from initiation to metastasis. EMT could be regarded as a continuum, with intermediate hybrid epithelial and mesenchymal phenotypes having high plasticity.
[Clinical Cancer Research]
Taki, M., Abiko, K., Ukita, M., Murakami, R., Yamanoi, K., Yamaguchi, K., Hamanishi, J., Baba, T., Matsumura, N., & Mandai, M. (2021). Tumor Immune Microenvironment during Epithelial-Mesenchymal Transition. Clinical Cancer Research. https://doi.org/10.1158/1078-0432.CCR-20-4459 Cite
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Nitidine Chloride Suppresses Epithelial-Mesenchymal Transition and Stem Cell-Like Properties in Glioblastoma by Regulating JAK2/STAT3 Signaling

Researchers investigated the inhibitory effect of nitidine chloride on the epithelial‐mesenchymal transition process and stem cell‐like properties in glioma cells.
[Cancer Medicine]
Jia, M., Wang, Y., Guo, Y., Yu, P., Sun, Y., Song, Y., & Zhao, L. (n.d.). Nitidine chloride suppresses epithelial-mesenchymal transition and stem cell-like properties in glioblastoma by regulating JAK2/STAT3 signaling. Cancer Medicine, n/a(n/a). https://doi.org/https://doi.org/10.1002/cam4.3869 Cite
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TFAP2A Potentiates Lung Adenocarcinoma Metastasis by a Novel miR-16 Family/TFAP2A/PSG9/TGF-β Signaling Pathway

Scientists investigated TFAP2A expression profiling, clinical significance, biological function and molecular underpinnings in LUAD.
[Cell Death & Disease]
Xiong, Y., Feng, Y., Zhao, J., Lei, J., Qiao, T., Zhou, Y., Lu, Q., Jiang, T., Jia, L., & Han, Y. (2021). TFAP2A potentiates lung adenocarcinoma metastasis by a novel miR-16 family/TFAP2A/PSG9/TGF-β signaling pathway. Cell Death & Disease, 12(4), 1–13. https://doi.org/10.1038/s41419-021-03606-x Cite
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LncRNA UCC Promotes Epithelial–Mesenchymal Transition via the miR-143-3p/SOX5 Axis in Non-Small-Cell Lung Cancer

A dual-luciferase reporter system and RIP assays showed that UCC specifically bound to miR-143-3p and acted as a sponge of miR-143-3p in NSCLC cells.
[Laboratory Investigation]
Chen, R., Zhang, C., Cheng, Y., Wang, S., Lin, H., & Zhang, H. (2021). LncRNA UCC promotes epithelial–mesenchymal transition via the miR-143-3p/SOX5 axis in non-small-cell lung cancer. Laboratory Investigation, 1–13. https://doi.org/10.1038/s41374-021-00586-6 Cite
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BCL3 Couples Cancer Stem Cell Enrichment with Pancreatic Cancer Molecular Subtypes

Scientists demonstrated that Bcl3 impacted pancreatic carcinogenesis by restraining cancer stem cell expansion and by curtailing an aggressive and metastatic tumor burden in pancreatic ductal adenocarcinoma across species.
[Gastroenterology]
Ai, J., Wörmann, S. M., Görgülü, K., Vallespinos, M., Zagorac, S., Alcala, S., Wu, N., Kabacaoglu, D., Berninger, A., Navarro, D., Kaya-Aksoy, E., Ruess, D. A., Ciecielski, K. J., Kowalska, M., Demir, E. I., Ceyhan, G. O., Heid, I., Braren, R., Riemann, M., … Algül, H. (2021). BCL3 couples cancer stem cell enrichment with pancreatic cancer molecular subtypes. Gastroenterology, 0(0). https://doi.org/10.1053/j.gastro.2021.03.051 Cite
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HomeoboxC6 Promotes Metastasis by Orchestrating the DKK1/Wnt/β-Catenin Axis in Right-Sided Colon Cancer

Hmeobox C6 was validated to be overexpressed in right-sided colon cancer and associated with poor prognosis.
[Cell Death & Disease]
Qi, L., Chen, J., Zhou, B., Xu, K., Wang, K., Fang, Z., Shao, Y., Yuan, Y., Zheng, S., & Hu, W. (2021). HomeoboxC6 promotes metastasis by orchestrating the DKK1/Wnt/β-catenin axis in right-sided colon cancer. Cell Death & Disease, 12(4), 1–13. https://doi.org/10.1038/s41419-021-03630-x Cite
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Zinc‐Finger E‐Box‐Binding Homeobox 1 (ZEB1) Plays a Crucial Role in the Maintenance of Lung Cancer Stem Cells Resistant to Gefitinib

PC9 and HCC827 non‐small cell lung cancer cell lines were treated with high concentrations of gefitinib, and surviving cells were referred to as “gefitinib‐resistant persisters” (GRPs). Zinc‐finger E‐box‐binding homeobox 1 (ZEB1) knockdown or overexpression was performed to determine the biological significance of ZEB1 in the cancer stem cell features of GRPs, and animal models were studied for in vivo validation.
[Thoracic Cancer]
Nurwidya, F., Takahashi, F., Winardi, W., Tajima, K., Mitsuishi, Y., Murakami, A., Kobayashi, I., Nara, T., Hashimoto, M., Kato, M., Hidayat, M., Suina, K., Hayakawa, D., Asao, T., Ko, R., Shukuya, T., Yae, T., Shimada, N., Yoshioka, Y., … Takahashi, K. (n.d.). Zinc-finger E-box-binding homeobox 1 (ZEB1) plays a crucial role in the maintenance of lung cancer stem cells resistant to gefitinib. Thoracic Cancer, n/a(n/a). https://doi.org/https://doi.org/10.1111/1759-7714.13937 Cite
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Circ-HMGA2 (hsa_circ_0027446) Promotes the Metastasis and Epithelial-Mesenchymal Transition of Lung Adenocarcinoma Cells through the miR-1236-3p/ZEB1 Axis

Through microarray analysis, investigators obtained the circRNA expression profile of lung adenocarcinoma and found that circ-HMGA2, a novel RNA, was highly expressed in lung adenocarcinoma.
[Cell Death & Disease]
Circ-HMGA2 (hsa_circ_0027446) promotes the metastasis and epithelial-mesenchymal transition of lung adenocarcinoma cells through the miR-1236-3p/ZEB1 axis | Cell Death & Disease. (n.d.). Retrieved March 25, 2021, from https://www.nature.com/articles/s41419-021-03601-2 Cite
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miR‑454‑3p Inhibits Non‑Small Cell Lung Cancer Cell Proliferation and Metastasis by Targeting TGFB2

miR‑454‑3p overexpression led to the suppression of proliferation, migration, and invasion in A549 and NCI‑H1650 cells. The overexpression of miR‑454‑3p in A549 and NCI‑H1650 cells significantly inhibited EMT. TGFB2 was revealed to be a direct target of miR‑454‑3p by using TargetScan database and luciferase reporter assay.
[Oncology Reports]
Liao, H., Liang, Y., Kang, L., Xiao, Y., Yu, T., & Wan, R. (2021). miR‑454‑3p inhibits non‑small cell lung cancer cell proliferation and metastasis by targeting TGFB2. Oncology Reports, 45(5), 1–12. https://doi.org/10.3892/or.2021.8018 Cite
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Isolating and Targeting the Real-Time Plasticity and Malignant Properties of Epithelial-Mesenchymal Transition in Cancer

3D high-content screening of ~23,000 compounds using dual-reporter mesenchymal SW620 tumor organoids identified small molecule probes that modulate EMT, and a subset of probes that effectively induced MET.
[Oncogene]
Esquer, H., Zhou, Q., Nemkov, T., Abraham, A. D., Rinaldetti, S., Chen, Y.-C., Zhang, X., Orman, M. V., D’Alessandro, A., Ferrer, M., Messersmith, W. A., & LaBarbera, D. V. (2021). Isolating and targeting the real-time plasticity and malignant properties of epithelial-mesenchymal transition in cancer. Oncogene, 1–14. https://doi.org/10.1038/s41388-021-01728-2 Cite
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Nongenotoxic ABCB1 Activator Tetraphenylphosphonium Can Contribute to Doxorubicin Resistance in MX-1 Breast Cancer Cell Line

Scientists describe possible mechanisms, that might contribute to upregulation of ABCB1 and synergistically boost the acquisition of doxorubicin resistance in breast cancer MX-1 cell line.
[Scientific Reports]
Kubiliute, R., Januskeviciene, I., Urbanaviciute, R., Daniunaite, K., Drobniene, M., Ostapenko, V., Daugelavicius, R., & Jarmalaite, S. (2021). Nongenotoxic ABCB1 activator tetraphenylphosphonium can contribute to doxorubicin resistance in MX-1 breast cancer cell line. Scientific Reports, 11(1), 6556. https://doi.org/10.1038/s41598-021-86120-6 Cite
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