Tag Archives: EMT

O-GlcNAc Modified-TIP60/KAT5 Is Required for PCK1 Deficiency-Induced HCC Metastasis

Gain- and loss-of-function studies demonstrate that phosphoenolpyruvate carboxykinase 1 (PCK1) suppressed hepatocellular carcinoma metastasis in vitro and in vivo. Specifically, lysine acetyltransferase 5 (KAT5) was highly modified by O-GlcNAcylation in PCK1 knockout hepatoma cells.
[Oncogene]
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Potentiated Lung Adenocarcinoma (LUAD) Cell Growth, Migration and Invasion by lncRNA DARS-AS1 via miR-188-5p/ KLF12 Axis

Cell functional experiments revealed that lncRNA DARS-AS1 participated in enhancing lung adenocarcinoma proliferation, invasion, and migration by inhibiting miR-188-5p.
[Aging]
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Fluid Flow Exposure Promotes Epithelial-to-Mesenchymal Transition and Adhesion of Breast Cancer Cells to Endothelial Cells

Researchers showed that fluid forces on the order of 1 Pa promoted epithelial-to-mesenchymal transition and adhesion of breast cancer cells to an endothelial monolayer and identified biomarkers were distinctly expressed in patient populations.
[Breast Cancer Research]
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The Long Non-Coding RNA ET-20 Mediates EMT by Impairing Desmosomes in Breast Cancer Cells

Researchers reported the identification of 114 novel long non-coding RNAs that changed their expression during TGFβ-induced epithelial-mesenchymal transition in murine breast cancer cells.
[Journal of Cell Science]
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SNAIL2 Contributes to Tumorigenicity and Chemotherapy Resistance in Pancreatic Cancer by Regulating IGFBP2

Scientists showed that the suppression of SNAIL2 expression using RNA interference decreased tumorigenicity in vitro and in vivo in two pancreatic cancer cell lines, KLM1 and KMP5.
[Cancer Science]
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Autophagy Provides a Conceptual Therapeutic Framework for Bone Metastasis from Prostate Cancer

The authors sum up the recent studies on the mechanism of bone metastasis involving key regulatory factors such as macrophages and AKT and further discusses as to how regulating autophagy is crucial in relieving prostate cancer bone metastasis.
[Cell Death & Disease]
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RNA Binding Protein RBMS3 Is a Common EMT Effector That Modulates Triple-Negative Breast Cancer Progression via Stabilizing PRRX1 mRNA

Scientists identified RNA Binding Motif Single Stranded Interacting Protein 3 (RBMS3) as a novel and common effector of epithelial-to-mesenchymal transition (EMT), which could be a promising therapeutic target for triple-negative breast cancer treatment.
[Oncogene]
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AHA1 Regulates Cell Migration and Invasion via the EMT Pathway in Colorectal Adenocarcinomas

To investigate how AHA1 expression regulated the cancer cell progression and/or metastasis of human colorectal cancer (CRC), the expression levels of AHA1 and Hsp90 were examined in 105 CRC tissue samples and compared with those in paired normal tissue.
[Scientific Reports]
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DCLK1-Short Splice Variant Promotes Esophageal Squamous Cell Carcinoma Progression Via the MAPK/ERK/MMP2 Pathway

Researchers found that the expression of DCLK1 isoform 4 (DCLK1-S) was significantly increased in human esophageal squamous cell carcinoma tissues and associated with malignant progression and poor prognosis.
[Molecular Cancer Research]
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LHPP Suppresses Colorectal Cancer Cell Migration and Invasion In Vitro and In Vivo by Inhibiting Smad3 Phosphorylation in the TGF-β Pathway

The Transwell assay and xenograft nude model showed that LHPP inhibited migration and invasion of colorectal cancer cells in vitro and in vivo, respectively. The expression of total and nuclear epithelial-to-mesenchymal transition-related proteins were significantly reduced after LHPP upregulation.
[Cell Death Discovery]
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Contribution of p53 in Sensitivity to EGFR Tyrosine Kinase Inhibitors in Non-Small Cell Lung Cancer

Researchers investigated the effects of p53 in primary sensitivity and acquired resistance to EGFR-TKIs in NSCLC cells.
[Scientific Reports]
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