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Epithelial-Mesenchymal Transition and Cancer Stem Cells: A Route to Acquired Cisplatin Resistance through Epigenetics in HNSCC

[Oral Diseases] The authors suggested that in the route to cisplatin chemoresistance, epigenetic modifications could be associated with epithelial-mesenchymal transition activation and cancer stem cell accumulation which originated more aggressive tumors.

Stem Cell Conversion to the Cardiac Lineage Requires Nucleotide Signaling from Apoptosing Cells

[Nature Cell Biology] Investigators observed that initiation of differentiation in iPSCs and ESCs triggered widespread apoptosis, followed by a synchronous epithelial–mesenchymal transition.

Transmural Myocardial Repair with Engineered Heart Muscle in a Rat Model of Heterotopic Heart Transplantation – a Proof-of-Concept Study

[Journal of Molecular and Cellular Cardiology] Investigators tested the outcome after implantation of contractile engineered heart muscle and non-contractile engineered connective tissue as well as engineered mesenchymal tissue allografts as transmural heart wall replacement.

Tumor Suppressive Role of MicroRNA-4731-5p in Breast Cancer through Reduction of PAICS-Induced FAK Phosphorylation

[Cell Death Discovery] Breast cancer-related microRNA (miRNA) and messenger RNA microarray data sets were retrieved for differential analyses. Subsequently, the expression patterns of miR-4731-5p, PAICS, and FAK in breast cancer tissues and cells were determined.

The miR-4732-5p/XPR1 Axis Suppresses the Invasion, Metastasis, and Epithelial–Mesenchymal Transition of Lung Adenocarcinoma via the PI3K/Akt/GSK3β/Snail Pathway

[Molecular Omics] Overexpression of miR-4732-5p significantly inhibited the migration, invasion, and metastasis of lung adenocarcinoma in vitro and in vivo, which could be reversed by overexpression of xenotropic and polytropic retrovirus receptor 1 (XPR1).

Vestigial-Like Family Member 3 Stimulates Cell Motility by Inducing High-Mobility Group AT-Hook 2 Expression in Cancer Cells

[Journal of Cellular and Molecular Medicine] Scientists found that A549 human lung cancer cells stably expressing vestigial-like family member 3 exhibited spindle-like morphological changes, reduction in the epithelial marker E-cadherin and induction of the mesenchymal marker Snail.