TMSB10 Can Serve as a Potential Prognosis Prediction Biomarker and Promotes the Invasion and Angiogenesis of Gastric Cancer

The thymosin beta 10’s roles and potential mechanisms in regulating tumor growth, invasion and angiogenesis were evaluated by TMSB10 knockdown/overexpression of gastric cancer cells in vitro and ex vivo.
[Journal of Gastroenterology and Hepatology]
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Evaluating the Effect of Secretome of Human Amniotic Mesenchymal Stromal Cells on Apoptosis Induction and Epithelial-Mesenchymal Transition Inhibition in LNCaP Prostate Cancer Cells Based on 2D and 3D Cell Culture Models

Scientists employed a co-culture system to evaluate the anti-epithelial-mesenchymal transition effects of human amniotic mesenchymal stromal cells on LNCaP PCa cells.
[Cell Biochemistry and Function]
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ISL1 Promoted Tumorigenesis and EMT via Aurora Kinase A-Induced Activation of PI3K/AKT Signaling Pathway in Neuroblastoma

Investigators identified Insulin gene enhancer binding protein 1 (ISL1) as an oncogene in neuroblastoma (NB). ISL1 is preferentially upregulated in NB tissues compared with normal tissues.
[Cell Death & Disease]
Li, M., Sun, C., Bu, X., Que, Y., Zhang, L., Zhang, Y., Zhang, L., Lu, S., Huang, J., Zhu, J., Wang, J., Sun, F., & Zhang, Y. (2021). ISL1 promoted tumorigenesis and EMT via Aurora kinase A-induced activation of PI3K/AKT signaling pathway in neuroblastoma. Cell Death & Disease, 12(6), 1–13. https://doi.org/10.1038/s41419-021-03894-3 Cite
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PB01 Suppresses Radio-Resistance by Regulating ATR Signaling in Human Non-Small-Cell Lung Cancer Cells

Scientists reported the antitumor effects and mechanism of a novel benzothiazole derivative 4-methoxy-cyclohexane carboxylic acid [2-(3,5-dimethyl-isoxazole-4-yl) sulpanil-benzothiazole-6-yl]-amide (PB01) in radiation-resistant human non-small-cell lung cancer cells.
[Scientific Reports]
Kim, T. W., Hong, D.-W., & Hong, S. H. (2021). PB01 suppresses radio-resistance by regulating ATR signaling in human non-small-cell lung cancer cells. Scientific Reports, 11(1), 12093. https://doi.org/10.1038/s41598-021-91716-z Cite
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Expression Pattern and Prognostic Impact of Glycoprotein Non-Metastatic B (GPNMB) in Triple-Negative Breast Cancer

Among 759 specimens, immunohistochemistry exhibited glycoprotein non-metastatic B (GPNMB) expressions were variable in different subtypes and significantly higher in TNBC. GPNMB positively correlated with epithelial–mesenchymal transition regulators, mesenchymal marker vimentin, MMP and integrins.
[Scientific Reports]
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RANKL Immunization Inhibits Prostate Cancer Metastasis by Modulating EMT through a RANKL-Dependent Pathway

The authors used preclinical experimental models to investigate whether an inactive form of receptor activator of nuclear factor kappa-B ligand (RANKL) affected bone metastasis in RANKL-induced prostate cancer.
[Scientific Reports]
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Exosomal Linc-ROR Mediates Crosstalk between Cancer Cells and Adipocytes to Promote Tumor Growth in Pancreatic Cancer

The effects of conditioned medium collected from dedifferentiated adipocytes on pancreatic cancer cell proliferation, motility, metastasis and epithelial-mesenchymal transition (EMT) were evaluated by western blot analysis, colony forming, real-time cell analysis, 5-ethynyl-2’-deoxyuridine, immunofluorescence, Transwell and wound healing assays in vitro.
[Molecular Therapy-Nucleic Acids]
Sun, Z., Sun, D., Feng, Y., Zhang, B., Sun, P., Zhou, B., Du, L., Wang, Y., Fan, Z., Yang, J., Li, Y., Hu, S., & Zhan, H. (2021). Exosomal Linc-ROR Mediates Crosstalk between Cancer Cells and Adipocytes to Promote Tumor Growth in Pancreatic Cancer. Molecular Therapy - Nucleic Acids, 0(0). https://doi.org/10.1016/j.omtn.2021.06.001 Cite
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Role of Cytoplasmic Localization of Maspin in Promoting Cell Invasion in Breast Cancer with Aggressive Phenotype

Scientists studied the biological function of cytoplasmic maspin in breast cancer cell lines. Subcellular localization of maspin in MDA-MB-231 breast cancer cells was mainly detected in the cytoplasm, whereas in MCF10A mammary epithelial cells, maspin was present in both cytoplasm and nucleus.
[Scientific Reports]
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Long Non-Coding RNA Lnc-408 Promotes Invasion and Metastasis of Breast Cancer Cell by Regulating LIMK1

Scientists found that Lnc-408, a novel long noncoding RNA, was significantly upregulated in breast cancer (BC) cells undergoing epithelial-mesenchymal transformation and in BC tumor with lymphatic metastases compared with those without lymphatic metastases.
[Oncogene]
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Inhibition of Triple Negative Breast Cancer Metastasis and Invasiveness by Novel Drugs That Target Epithelial to Mesenchymal Transition

Using an in vitro model of epithelial to mesenchymal transition (EMT), investigators showed that nitrofen interfered with the process of EMT and promoted mesenchymal to epithelial transformation.
[Scientific Reports]
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Comprehensive Profiling of Novel Epithelial–Mesenchymal Transition Mediators and Their Clinical Significance in Colorectal Cancer

To comprehensively profile epithelial–mesenchymal transition (EMT)-related genes in colorectal cancer, investigators quantified the EMT induction ability of each gene according to its similarity to the cancer stromal gene signature and termed it “mesenchymal score.”
[Scientific Reports]
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