[Oral Diseases] The authors suggested that in the route to cisplatin chemoresistance, epigenetic modifications could be associated with epithelial-mesenchymal transition activation and cancer stem cell accumulation which originated more aggressive tumors.
[Journal of Molecular and Cellular Cardiology] Investigators tested the outcome after implantation of contractile engineered heart muscle and non-contractile engineered connective tissue as well as engineered mesenchymal tissue allografts as transmural heart wall replacement.
[Cell Death Discovery] Breast cancer-related microRNA (miRNA) and messenger RNA microarray data sets were retrieved for differential analyses. Subsequently, the expression patterns of miR-4731-5p, PAICS, and FAK in breast cancer tissues and cells were determined.
[Molecular Omics] Overexpression of miR-4732-5p significantly inhibited the migration, invasion, and metastasis of lung adenocarcinoma in vitro and in vivo, which could be reversed by overexpression of xenotropic and polytropic retrovirus receptor 1 (XPR1).
[Journal of Cellular and Molecular Medicine] Scientists found that A549 human lung cancer cells stably expressing vestigial-like family member 3 exhibited spindle-like morphological changes, reduction in the epithelial marker E-cadherin and induction of the mesenchymal marker Snail.