EMT

[Nature Communications] The authors showed that persistent oncogenic RAS signaling caused highly metastatic triple-negative mammary tumors in mice. The continuous signaling of oncogenic RAS played a crucial role in the cellular plasticity and maintenance of the mesenchymal and stem cell characteristics of claudin-low mammary cancer cells.

[Acta Pharmacologica Sinica] Scientists demonstrated that oroxylin A, a natural product extracted from Scutellaria radix, significantly inhibited transforming growth factor-beta1-induced epithelial–mesenchymal transition and metastasis in hepatocellular carcinoma.

[Journal of Gastroenterology and Hepatology] The thymosin beta 10's roles and potential mechanisms in regulating tumor growth, invasion and angiogenesis were evaluated by TMSB10 knockdown/overexpression of gastric cancer cells in vitro and ex vivo.

[Cell Death & Disease] Investigators identified Insulin gene enhancer binding protein 1 (ISL1) as an oncogene in neuroblastoma (NB). ISL1 is preferentially upregulated in NB tissues compared with normal tissues.

[Cell Biochemistry and Function] Scientists employed a co-culture system to evaluate the anti-epithelial-mesenchymal transition effects of human amniotic mesenchymal stromal cells on LNCaP PCa cells.

[Scientific Reports] Among 759 specimens, immunohistochemistry exhibited glycoprotein non-metastatic B (GPNMB) expressions were variable in different subtypes and significantly higher in TNBC. GPNMB positively correlated with epithelial–mesenchymal transition regulators, mesenchymal marker vimentin, MMP and integrins.