FLT3-ITD

[Blood Cancer Journal] OTS167 alone or in combination with tyrosine kinase inhibitors were used to investigate the effect of OTS167 on FLT3 signaling and expression in human Fms-like tyrosine kinase 3 (FLT3) mutant acute myeloid leukemia cell lines and primary cells.

[Oncogenesis] Using a recently developed specific inhibitor, the authors found that vacuolar protein sorting 34 inhibition induces apoptosis in acute myeloid leukemia cells but not in normal CD34+ hematopoietic cells.

[Cell Death & Disease] Scientists reported that a newly emerged histone deacetylase inhibitor, chidamide, at low-cytotoxicity dose enhanced the anti-AML activity of ABT-199, while sparing normal hematopoietic progenitor cells.

[Cell Cycle] The author summarizes the role of all-trans retinoic acidin normal hematopoiesis and in cute amyeloid leukemia (AML), focusing on its impact on AML stem cells.

[Cell Cycle] This authors summarize the role of all-trans retinoic acid in normal hematopoiesis and in acute myeloid leukemia (AML), focusing on its impact on AML stem cells.

[Blood Cancer Journal] Investigators characterized the distribution of FLT3-ITD mutation in different progenitor cell subsets to shed light on the subclonal architecture of FLT3-ITDmut acute myeloid leukemia.