Fos

[Nature] Investigators reveal an instructive role for FOS and SCG2 in establishing a network of Fos-activated neurons via the rewiring of local inhibition to form a selectively modulated state.

[Nature Communications] Researchers devised a simple, efficient and non-patient-specific gene-editing strategy through targeting of two introns of the genes involved in the rearrangement, allowing for robust disruption of the fusion oncogenes specifically in cancer cells.

[Proceedings of the National Academy of Sciences of the United States of America] Scientists showed that NR4A3-deficient murine CD8+ T cells differentiated preferentially into memory precursor and central memory cells, but also produced more cytokines.

[Cell Systems] Scientists found that the stress-like subpopulation of cancer cells was present from the early stages of tumorigenesis.

[Science] Importin α3–bound c-Fos and importin α3–deficient neurons were impaired in c-Fos nuclear import. Knockdown or dominant-negative inhibition of c-Fos or c-Jun in sensory neurons reduced neuropathic pain.

[Molecular and Cellular Biochemistry] The addition of chelerythrine significantly inhibited the proliferation of androgen-independent prostate cancer DU145 and PC-3 cells at the concentration of 5 and 10 μM, but not on androgen-dependent prostate cancer LNCaP cells as well as normal prostate epithelial cell line PrEC cells.