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Pulmonary Cell NewsResearchers devised a simple, efficient and non-patient-specific gene-editing strategy through targeting of two introns of the genes involved in the rearrangement, allowing for robust disruption of the fusion oncogenes specifically in cancer cells.
[Nature Communications]
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Martinez-Lage, M., Torres-Ruiz, R., Puig-Serra, P., Moreno-Gaona, P., Martin, M. C., Moya, F. J., Quintana-Bustamante, O., Garcia-Silva, S., Carcaboso, A. M., Petazzi, P., Bueno, C., Mora, J., Peinado, H., Segovia, J. C., Menendez, P., & Rodriguez-Perales, S. (2020). In vivo CRISPR/Cas9 targeting of fusion oncogenes for selective elimination of cancer cells. Nature Communications, 11(1), 5060. https://doi.org/10.1038/s41467-020-18875-x Cite
