C-FOS Drives Reversible Basal to Squamous Cell Carcinoma Transition

Researchers used surface markers of resistant basal cell carcinomas and patient single-cell and bulk transcriptomic data, and uncovered the dynamic roadmap of basal to squamous cell carcinoma transition.
[Cell Reports]
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SCIMP Is a Spatiotemporal Transmembrane Scaffold for Erk1/2 to Direct Pro-Inflammatory Signaling in TLR-Activated Macrophages

The authors revealed that the immune-specific transmembrane adaptor SCIMP was a direct scaffold for Erk1/2 in TLR pathways, with high-resolution, live-cell imaging revealing that SCIMP guided the spatial and temporal recruitment of Erk2 to membrane ruffles and macropinosomes for pro-inflammatory TLR4 signaling.
[Cell Reports]
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Regulation and Function of AP-1 in Insulinoma Cells and Pancreatic β-Cells

The authors investigated the intracellular signaling pathway following stimulation of Cav1.2 Ca2+ channels and addressed the function of the transcription factor activator protein-1 in pancreatic β-cells of transgenic mice.
[Biochemical Pharmacology]
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Drivers and Suppressors of Triple-Negative Breast Cancer

Researchers found that except for SP1, the other tethering partners of ERβ (Fos, Jun, Fra1) were down-regulated in TNBC, meaning that the tumor-suppressive functions of ERβ were severely compromised.
[Proceedings of the National Academy of Sciences of the United States of America]
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CCL2 Associated with CD38 Expression during Ex Vivo Expansion in Human Cord Blood-Derived Hematopoietic Stem Cells

Researchers compared the gene expression profiles of HSCs in ex vivo expanded serum and serum-free culture systems and analyzed the molecular functions of differentially expressed genes using microarray chips.
[Aging-Us]
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Fosl1 Is Vital to Heart Regeneration upon Apex Resection in Adult Xenopus tropicalis

Researchers demonstrated that cardiomyocyte proliferation greatly contributed to heart regeneration in adult Xenopus tropicalis upon apex resection.
[NPJ Regenerative Medicine]
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Inhibitors of PD-1/PD-L1 and ERK1/2 Impede the Proliferation of Receptor Positive and Triple-Negative Breast Cancer Cell Lines

The effect of combined PD-1/PD-L1 and extracellular signal-regulated kinase 1/2 (ERK1/2) inhibitor treatment was investigated of cell growth and intracellular impact of breast cancer cell lines.
[Journal of Cancer Research and Clinical Oncology]
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Plantaricin NC8 αβ Prevents Staphylococcus aureus-Mediated Cytotoxicity and Inflammatory Responses of Human Keratinocytes

Investigators characterized the antimicrobial effects of PLNC8 αβ on cell signaling pathways and inflammatory responses of human keratinocytes infected with S. aureus.
[Scientific Reports]
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The lncRNA XIST/miR-150-5p/C-Fos Axis Regulates Sepsis-Induced Myocardial Injury via TXNIP-Modulated Pyroptosis

The authors investigated the role of lncRNA X-inactive specific transcript (XIST) in septic myocardial injury and explored its mechanism.
[Laboratory Investigation]
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Hematopoietic Stem Cells Retain Functional Potential and Molecular Identity in Hibernation Cultures

The authors describe a powerful seven day HSC hibernation culture system that maintained HSCs as single cells in the absence of a physical niche.
[Stem Cell Reports]
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RNA-Seq of Human T Cells after Hematopoietic Stem Cell Transplantation Identifies Linc00402 as a Regulator of T Cell Alloimmunity

Linc00402 was increased in donor T cells from patients who underwent allogeneic cardiac transplantation and in murine T cells.
[Science Translational Medicine]
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