GDF15 Promotes Glioma Stem Cell-Like Phenotype via Regulation of ERK1/2–C-Fos–LIF Signaling

The authors report that growth differentiation factor 15 (GDF15) promotes the glioma stem cell (GSC)-like phenotype in GSC-like cells through the activation of leukemia inhibitor factor (LIF)–STAT3 signaling.
[Cell Death Discovery]
Zhu, S., Yang, N., Guan, Y., Wang, X., Zang, G., Lv, X., Deng, S., Wang, W., Li, T., & Chen, J. (2021). GDF15 promotes glioma stem cell-like phenotype via regulation of ERK1/2–c-Fos–LIF signaling. Cell Death Discovery, 7(1), 1–12. https://doi.org/10.1038/s41420-020-00395-8 Cite
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Locally Applied Stem Cell Exosome-Scaffold Attenuates Nerve Injury-Induced Pain in Rats

Researchers developed an alginate scaffold with human umbilical cord mesenchymal stem cell exosomes to treat nerve injury-induced pain. In vitro studies of PC12 and HEK293 cells were used to evaluate the neuroprotective and neurotrophic effects of exosomes.
[Journal of Pain Research]
Hsu, J.-M., Shiue, S.-J., Yang, K. D., Shiue, H.-S., Hung, Y.-W., Pannuru, P., Poongodi, R., Lin, H.-Y., & Cheng, J.-K. (2020, December 4). <p>Locally Applied Stem Cell Exosome-Scaffold Attenuates Nerve Injury-Induced Pain in Rats</p>. Journal of Pain Research. https://doi.org/10.2147/JPR.S286771 Cite
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Recurrent FOS Rearrangement in Proliferative Fasciitis/Proliferative Myositis

c-FOS immunohistochemistry was negative in 45 cases of selected mesenchymal tumor types with epithelioid components that may histologically mimic PF/PM, including pleomorphic sarcoma with epithelioid features and epithelioid sarcoma.
[Modern Pathology]
Makise, N., Mori, T., Motoi, T., Shibahara, J., Ushiku, T., & Yoshida, A. (2020). Recurrent FOS rearrangement in proliferative fasciitis/proliferative myositis. Modern Pathology, 1–9. https://doi.org/10.1038/s41379-020-00725-2 Cite
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Bidirectional Perisomatic Inhibitory Plasticity of a Fos Neuronal Network

Investigators reveal an instructive role for FOS and SCG2 in establishing a network of Fos-activated neurons via the rewiring of local inhibition to form a selectively modulated state.
[Nature]
Yap, E.-L., Pettit, N. L., Davis, C. P., Nagy, M. A., Harmin, D. A., Golden, E., Dagliyan, O., Lin, C., Rudolph, S., Sharma, N., Griffith, E. C., Harvey, C. D., & Greenberg, M. E. (2020). Bidirectional perisomatic inhibitory plasticity of a Fos neuronal network. Nature, 1–7. https://doi.org/10.1038/s41586-020-3031-0 Cite
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In Vivo CRISPR/Cas9 Targeting of Fusion Oncogenes for Selective Elimination of Cancer Cells

Researchers devised a simple, efficient and non-patient-specific gene-editing strategy through targeting of two introns of the genes involved in the rearrangement, allowing for robust disruption of the fusion oncogenes specifically in cancer cells.
[Nature Communications]
Martinez-Lage, M., Torres-Ruiz, R., Puig-Serra, P., Moreno-Gaona, P., Martin, M. C., Moya, F. J., Quintana-Bustamante, O., Garcia-Silva, S., Carcaboso, A. M., Petazzi, P., Bueno, C., Mora, J., Peinado, H., Segovia, J. C., Menendez, P., & Rodriguez-Perales, S. (2020). In vivo CRISPR/Cas9 targeting of fusion oncogenes for selective elimination of cancer cells. Nature Communications, 11(1), 5060. https://doi.org/10.1038/s41467-020-18875-x Cite
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Early Programming of CD8+ T Cell Response by the Orphan Nuclear Receptor NR4A3

Scientists showed that NR4A3-deficient murine CD8+ T cells differentiated preferentially into memory precursor and central memory cells, but also produced more cytokines.
[Proceedings of the National Academy of Sciences of the United States of America]
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The Stress-Like Cancer Cell State Is a Consistent Component of Tumorigenesis

Scientists found that the stress-like subpopulation of cancer cells was present from the early stages of tumorigenesis.
[Cell Systems]
Baron, M., Tagore, M., Hunter, M. V., Kim, I. S., Moncada, R., Yan, Y., Campbell, N. R., White, R. M., & Yanai, I. (2020). The Stress-Like Cancer Cell State Is a Consistent Component of Tumorigenesis. Cell Systems, 0(0). https://doi.org/10.1016/j.cels.2020.08.018 Cite
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Importin α3 Regulates Chronic Pain Pathways in Peripheral Sensory Neurons

Importin α3–bound c-Fos and importin α3–deficient neurons were impaired in c-Fos nuclear import. Knockdown or dominant-negative inhibition of c-Fos or c-Jun in sensory neurons reduced neuropathic pain.
[Science]
Marvaldi, L., Panayotis, N., Alber, S., Dagan, S. Y., Okladnikov, N., Koppel, I., Pizio, A. D., Song, D.-A., Tzur, Y., Terenzio, M., Rishal, I., Gordon, D., Rother, F., Hartmann, E., Bader, M., & Fainzilber, M. (2020). Importin α3 regulates chronic pain pathways in peripheral sensory neurons. Science, 369(6505), 842–846. https://doi.org/10.1126/science.aaz5875 Cite
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Chelerythrine Suppresses Proliferation and Metastasis of Human Prostate Cancer Cells via Modulating MMP/TIMP/NF-κB System

The addition of chelerythrine significantly inhibited the proliferation of androgen-independent prostate cancer DU145 and PC-3 cells at the concentration of 5 and 10 μM, but not on androgen-dependent prostate cancer LNCaP cells as well as normal prostate epithelial cell line PrEC cells.
[Molecular and Cellular Biochemistry]
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FOSL1 Is a Novel Mediator of Endotoxin/Lipopolysaccharide-Induced Pulmonary Angiogenic Signaling

Researchers undertook an unbiased discovery approach to identify novel signaling pathways programming sepsis-induced deviant lung angiogenesis. Pulmonary endothelial cells were isolated for RNA-Seq from newborn C57BL/6 mice treated with intraperitoneal lipopolysaccharide to mimic systemic sepsis.
[Scientific Reports]
Nitkin, C. R., Xia, S., Menden, H., Yu, W., Xiong, M., Heruth, D. P., Ye, S. Q., & Sampath, V. (2020). FOSL1 is a novel mediator of endotoxin/lipopolysaccharide-induced pulmonary angiogenic signaling. Scientific Reports, 10(1), 13143. https://doi.org/10.1038/s41598-020-69735-z Cite
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