Linc01133 Contributes to Gastric Cancer Growth by Enhancing YES1-Dependent YAP1 Nuclear Translocation via Sponging miR-145-5p

Scientists found that linc01133 was significantly upregulated in gastric cancer tissues compared to non-tumorous gastric tissues. Linc01133 over-expression significantly correlated with tumor size and tumor differentiation in gastric cancer patients.
[Cell Death & Disease]
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Single-Cell Analysis Reveals the Immune Characteristics of Myeloid Cells and Memory T Cells in Recovered COVID-19 Patients with Different Severities

According to large-scale single-cell analysis, recovered patients, who had severe symptoms, still exhibited peripheral immune disorders one-two months after symptom onset.
[Frontiers in Immunology]
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Hepatic IRF8 Expression Suppresses Hepatocellular Carcinoma Progression and Enhances the Response to Anti-PD-1 Therapy

Scientists identified interferon regulatory factor (IRF8) as an important prognostic biomarker in hepatocellular carcinoma patients which predicted the response and sensitivity to anti-PD-1 therapy.
[Hepatology]
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Fos Regulates Macrophage Infiltration against Surrounding Tissue Resistance by a Cortical Actin-Based Mechanism in Drosophila

Investigators found that the tissue invasion of Drosophila macrophages, also known as plasmatocytes or hemocytes, utilized enhanced cortical F-actin levels stimulated by the Drosophila member of the fos proto oncogene transcription factor family.
[PLoS Biology]
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Prostate-Specific Membrane Antigen Modulates the Progression of Prostate Cancer by Regulating the Synthesis of Arginine and Proline and the Expression of Androgen Receptors and Fos Proto-Oncogenes

Scientists constructed prostate-specific membrane antigen (PSMA)-knockdown LNCaP and 22rv1 cell lines and performed metabonomic and transcriptomic analyses to determine the effects of PSMA on prostate cancer metabolism and transcription.
[Bioengineered]
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NRIP1 Is Activated by C-JUN/C-FOS and Activates the Expression of PGR, ESR1 and CCND1 in Luminal a Breast Cancer

Researchers identified differentially expressed genes via a comparison between luminal A breast cancer subtypes and normal mammary ductal cells from healthy donors.
[Scientific Reports]
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C-FOS Drives Reversible Basal to Squamous Cell Carcinoma Transition

Researchers used surface markers of resistant basal cell carcinomas and patient single-cell and bulk transcriptomic data, and uncovered the dynamic roadmap of basal to squamous cell carcinoma transition.
[Cell Reports]
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SCIMP Is a Spatiotemporal Transmembrane Scaffold for Erk1/2 to Direct Pro-Inflammatory Signaling in TLR-Activated Macrophages

The authors revealed that the immune-specific transmembrane adaptor SCIMP was a direct scaffold for Erk1/2 in TLR pathways, with high-resolution, live-cell imaging revealing that SCIMP guided the spatial and temporal recruitment of Erk2 to membrane ruffles and macropinosomes for pro-inflammatory TLR4 signaling.
[Cell Reports]
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Regulation and Function of AP-1 in Insulinoma Cells and Pancreatic β-Cells

The authors investigated the intracellular signaling pathway following stimulation of Cav1.2 Ca2+ channels and addressed the function of the transcription factor activator protein-1 in pancreatic β-cells of transgenic mice.
[Biochemical Pharmacology]
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Drivers and Suppressors of Triple-Negative Breast Cancer

Researchers found that except for SP1, the other tethering partners of ERβ (Fos, Jun, Fra1) were down-regulated in TNBC, meaning that the tumor-suppressive functions of ERβ were severely compromised.
[Proceedings of the National Academy of Sciences of the United States of America]
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CCL2 Associated with CD38 Expression during Ex Vivo Expansion in Human Cord Blood-Derived Hematopoietic Stem Cells

Researchers compared the gene expression profiles of HSCs in ex vivo expanded serum and serum-free culture systems and analyzed the molecular functions of differentially expressed genes using microarray chips.
[Aging-Us]
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