Prostate-Specific Membrane Antigen Modulates the Progression of Prostate Cancer by Regulating the Synthesis of Arginine and Proline and the Expression of Androgen Receptors and Fos Proto-Oncogenes

Scientists constructed prostate-specific membrane antigen (PSMA)-knockdown LNCaP and 22rv1 cell lines and performed metabonomic and transcriptomic analyses to determine the effects of PSMA on prostate cancer metabolism and transcription.