GLI1

[Acta Pharmacologica Sinica] Berberine promotes the degradation of SHH mRNA in colorectal cancer cells, interrupting the paracrine Hedgehog signaling pathway activity thus suppresses the colorectal cancer growth.

[Oncogene] Investigators showed that novel combinations of JAK2 inhibitors with SMO inhibitors synergistically inhibited in vitro growth of TNBC and HER2-positive trastuzumab-resistant BT474-TtzmR cells.

[Oncogene] Researchers presented a therapeutically relevant crosstalk between Hedgehog (HH) signaling and the glucocorticoid receptor pathway acting at the level of GLI1 transcription factor.

[Cell Death & Disease] The authors showed that LIN28B-AS1 was expressed in established/primary human hepatocellular carcinoma (HCC) cells and HCC tissues. RNA-immunoprecipitation and RNA pull-down results confirmed that LIN28B-AS1 directly associated with IGF2BP1 protein in HCC cells.

[Nucleic Acids Research] Investigators found that glioma-associated oncogene family zinc finger 1was activated in TNBC cells in response to ionizing radiation (IR) and localized to ribosomal DNA (rDNA) sequences in response to both global double-strand breaks (DSBs) generated by IR and site-specific DSBs in rDNA.

[Phytomedicine] Colony formation assay and flow cytometry were used to evaluate the effect of garcinone C on the proliferation and cell cycle progression of colon cancer cells.