H3K27

[PLoS Genetics] Scientists showed that stable overexpression of MED19 in androgen-dependent LNCaP cells promoted growth under conditions of androgen deprivation.

[Nature Communications] Investigators identified the histone methyltransferase Mll1 as a regulator of Wnt-driven intestinal cancer. Mll1 is highly expressed in Lgr5+ stem cells and human colon carcinomas with increased nuclear β-catenin.

[Molecular Therapy-Nucleic Acids] The authors analyzed the epigenetic alterations of long non-coding RNAs (lncRNAs) at important regulatory elements in three breast cancer subtypes.

[Nature] Researchers generated a conditional triple-H1-knockout mouse strain and depleted H1 in haematopoietic cells. H1 depletion in T cells leads to de-repression of T cell activation genes, a process that mimics normal T cell activation.

[Hepatology] In vitro, epigenome‐editing of carbon tetrachloride (CCL2) enhancer and promoter regions by CRISPR‐dCas9‐KRAB technology repressed TNFα‐induced CCL2 transcription via H3K9 tri‐methylation.

[Blood] In 290 normal subjects from the GeneSTAR Research Study, investigators generated whole genome sequence data from whole blood and RNA sequence data from extracted non-ribosomal RNA from 185 induced pluripotent stem cell-derived megakaryocyte cell lines and 290 blood platelet samples from these subjects.