HIV

[BMC Immunology] Investigators analyzed the profile of regulatory T cells and their correlation with the status of T cells activation, the expression of IL-2 and IFNγ, and the profile of HIV-1 specific antibodies response in Mozambican people living chronically with HIV-1.

[PLoS Pathogens] Researchers showed that the transcriptional co-activator and the central mediator of canonical Wnt signaling, β-catenin, inhibited HIV transcription in CD4+ T cells via TCF-4 LTR binding sites.

[Cell Reports] Scientists found that proteasomal activity generated multiple length variants of KK10, which bound TAP and human leukocyte antigen-B∗27:05.

[JCI Insight] Scientists examined the spatial localization, phenotype, and function of CD8+ T cells in the human duodenal tissue from people living with HIV and healthy controls.

[PLoS Pathogens] Researchers investigated whether infusion of T cells expressing an simian immunodeficiency virus-specific chimeric antigen receptor and the follicular homing receptor, CXCR5, could successfully kill viral-RNA+ cells in targeted lymphoid follicles in SIV-infected rhesus macaques.

[Ebiomedicine] Scientists review recent evidence on the role of immune checkpoints in persistent HIV infection and discuss the potential for employing immune checkpoint blockade as a therapeutic approach to target HIV persistence on antiretroviral therapy.