HIV

[Nature Communications] Ex vivo characterization of single Gag-specific CD4+ T cells revealed an advanced Th1 differentiation pattern in controllers, except for the CCR5 marker, which was downregulated compared to specific cells of treated patients.

[Molecular Therapy-Methods & Clinical Development] In a humanized mouse model under HIV-1 challenge, CXCR4-disrupted CD4+ T cells were enriched in the peripheral blood and spleen, indicating survival advantage due to resistance to viral infection.

[AIDS] Researchers studied CD4/CD8 over time to determine whether it predicted risk for select comorbidities and mortality among aging people with HIV with viral suppression.

[Scientific Reports] Using RNA-Seq, the authors explored CD4 T cell gene expression to identify evidence of a mechanism that might underpin virological rebound and lead to discovery of associated biomarkers.

[Proceedings of the National Academy of Sciences of the United States of America] Scientists reported that NRP-1, encoding transmembrane protein neuropilin-1, was highly expressed in macrophages and dendritic cells but not CD4+ T cells, serving as an anti-HIV factor to inhibit the infectivity of HIV-1 progeny virions.

[Nature Communications] Investigators showed the administration of allogeneic human peripheral blood natural killer cells delays viral rebound following interruption of anti-retroviral therapy in humanized mice infected with HIV-1.