HMGB1

[Aging] Researchers showed that ANRIL was up-regulated while miR-181a was down-regulated in pancreatic cancer tissues and HMGB1 was highly expressed. Knockdown of ANRIL in pancreatic cancer repressed cellular proliferation, invasion, migration, and reduced chemotherapy resistance to gemcitabine.

[Nature Communications] Researchers reported and characterized a long noncoding RNA, termed Brain Specific DNA-damage Related lncRNA1 (BS-DRL1), in the central nervous system.

[Journal of Biochemical and Molecular Toxicology] Using human vascular smooth muscle cells (VSMCs) treated by oxidized low-density lipoprotein to establish an atherosclerosis cell model, researchers explored the functional roles and molecular mechanisms of miR-141-5p in VSMCs dysfunction.

[Proceedings of the National Academy of Sciences of the United States of America] To understand the pathophysiology of COVID-19 infection, it is necessary to understand cell function during hypoxia. Researchers investigated aspects of human monocyte activation under hypoxic conditions.

[Science Translational Medicine] Researchers identified the alarmin high-mobility group box 1 (HMGB1) as a functional link between oxidative stress and inflammation in muscular dystrophies and demonstrated that the balance between HMGB1 redox isoforms dictated whether skeletal muscle was in an inflamed or regenerating state.

[Journal of Cellular and Molecular Medicine] Scientists tested the hypothesis that combined therapy with human umbilical cord‐derived mesenchymal stem cells and hyperbaric oxygen was superior to either one on preserving neurological function and reducing brain haemorrhagic volume in rat after acute intracerebral haemorrhage induced by intracranial injection of collagenase.