HMGB1

[Cell Death & Disease] Researchers showed that oleandrin treatment triggered breast cancer cell immunogenic cell death by inducing calreticulin exposure on cell surface and the release of high-mobility group protein B1, heat shock protein 70/90, and adenosine triphosphate.

[Scientific Reports] Researchers established unequivocal evidence that high-mobility group box-1 (HMGB1) released in vitro impairs oligodendrocyte progenitor cell response to mechanical injury; an effect that is pharmacologically reversible.

[Cell Death & Differentiation] Using bone marrow transplantation and cell type-specific Casp3 knockout mice, scientists demonstrated that Casp3/GSDME-mediated pyroptosis in renal parenchymal cells, but not in hematopoietic cells, played predominant roles in this process.

[Ca-A Cancer Journal For Clinicians] Researchers showed that TX100-induced plasma membrane damage and death by necroptosis were both attenuated by surfactant polymer dressing, allowing keratinocyte survival.

[Journal of Cellular Physiology] Investigators tested the direct effect of triciribine on ACE2 expression in human bronchial (H441) and lung alveolar (A549) epithelial cells.

[Environmental Toxicology] Investigators evaluated the effects of purified verbascoside on human prostate cancer and the associated molecular mechanisms.