Investigators Modified the Classical Antigen-Induced Arthritis Model by Using Citrullinated Human Plasma Fibrinogen as an Immunogen to Investigate the Mechanism of Inflammation-Driven Joint Damage by Citrullinated hFIB in C57BL/6 Mice.

Scientists modified the classical antigen-induced arthritis model by using citrullinated human plasma fibrinogen as an immunogen to investigate the mechanism of inflammation-driven joint damage by citrullinated human plasma fibrinogen (hFIB) in C57BL/6 mice.
[International Immunopharmacology]
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TWEAK Functions with TNF and IL-17 on Keratinocytes and Is a Potential Target for Psoriasis Therapy

Researchers showed that mice having a keratinocyte-specific deletion of Fn14, the receptor for the tumor necrosis factor (TNF) superfamily cytokine TWEAK, displayed reduced imiquimod-induced skin inflammation, diminished epidermal hyperplasia and less expression of psoriasis signature genes.
[Science Immunology]
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Inhibition of Keratinocyte Ferroptosis Suppresses Psoriatic Inflammation

The authors investigated a previously unrecognized role for ferroptosis in psoriasis, where ferroptosis was mediated by lipid peroxidation and iron overload. They found that ferrostatin-1 blocked inflammatory responses in vitro and in vivo, which reduced cytokine production.
[Cell Death & Disease]
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Attenuation of Apoptotic Cell Detection Triggers Thymic Regeneration after Damage

The authors demonstrated a trigger of thymic regeneration, centered on detecting the loss of dying thymocytes that were abundant during steady-state T cell development.
[Cell Reports]
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AbbVie Submits Regulatory Application to FDA for Risankizumab-Rzaa (SKYRIZI®) for the Treatment of Patients 16 Years and Older with Moderate to Severe Crohn’s Disease

AbbVie announced that it has submitted an application to the US FDA seeking approval for risankizumab-rzaa, an interleukin-23 inhibitor, for the treatment of patients 16 years and older with moderate to severe Crohn’s disease.
[AbbVie, Inc.]
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Monocyte-Derived and M1 Macrophages from Ankylosing Spondylitis Patients Released Higher TNF-α and Expressed More IL1B in Response to BzATP than Macrophages from Healthy Subjects

Scientists investigated the effect of 2ʹ(3ʹ)-O-(4-benzoyl benzoyl) ATP (BzATP) on the production of inflammatory cytokines in both monocyte-generated and M1 macrophages from patients and controls.
[Scientific Reports]
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Redundant Cytokine Requirement for Intestinal Microbiota-Induced Th17 Cell Differentiation in Draining Lymph Nodes

Scientists showed that intestine-draining mesenteric lymph nodes, not intestine proper, were the dominant site of segmented filamentous bacteria-induced intestinal Th17 cell differentiation.
[Cell Reports]
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Enhanced NF-κB Signaling in Type-2 Dendritic Cells at Baseline Predicts Non-Response to Adalimumab in Psoriasis

Lesional skin of non-responders contains higher numbers of dermal dendritic cells expressing the maturation marker CD83 and producing IL-23, and increased numbers of IL-17+ T cells.
[Nature Communications]
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Neutralization of IL-33 Modifies the Type 2 and Type 3 Inflammatory Signature of Viral Induced Asthma Exacerbation

Sensitized BALB/c mice were challenged with aerosolized ovalbumin (OVA) to establish allergic inflammation, followed by RSV-A2 infection to yield four treatment groups: saline only, RSV-infected alone, OVA alone, and OVA-treated with RSV infection
[Respiratory Research]
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Inherited PD-1 Deficiency Underlies Tuberculosis and Autoimmunity in a Child

Investigators studied a patient with inherited PD-1 deficiency and tuberculosis who died of pulmonary autoimmunity. The patient’s leukocytes did not express PD-1 or respond to PD-1-mediated suppression.
[Nature Medicine]
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Limited Intestinal Inflammation despite Diarrhea, Fecal Viral RNA and SARS-CoV-2-Specific IgA in Patients with Acute COVID-19

In lieu of tissue samples, investigators measured cytokines, inflammatory markers, viral RNA, microbiome composition, and antibody responses in stool samples from a cohort of 44 hospitalized COVID-19 patients.
[Scientific Reports]
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