Del Duca, E., Morelli, P., Bennardo, L., Di Raimondo, C., & Nisticò, S. P. (2020). Cytokine Pathways and Investigational Target Therapies in Hidradenitis Suppurativa. International Journal of Molecular Sciences, 21(22), 8436. https://doi.org/10.3390/ijms21228436Cite
Scientists found that the expression of galectin-7 was reduced in the skin lesions of patients with psoriasis. IL-17A and TNF-α, two cytokines intimately involved in the development of psoriatic lesions, suppressed galectin-7 expression in human primary keratinocytes and the immortalized human keratinocyte cell line HaCaT.
Investigators review new insights regarding the pathogenesis of psoriasis, as it relates to dendritic cells, Langerhans cells, macrophages, the signal transducer and activator of transcription 3 pathway, and aryl hydrocarbon receptor in cutaneous vascular endothelial cells.
Investigators used conventional and novel sequential immunostaining and flow cytometry to scrutinize RA-responsive T-cells in tissues and blood of allogeneic hematopoietic stem-cell transplantation patients and characterized the impact of RA on human T-cell alloresponses.
The authors found that the Pellino ubiquitin E3 ligase is activated by innate pattern-recognition receptors, such as Toll-like receptors, and was highly upregulated in human psoriatic skin lesions and murine psoriasis-like models.
Wilharm, A., Brigas, H. C., Sandrock, I., Ribeiro, M., Amado, T., Reinhardt, A., Demera, A., Hoenicke, L., Strowig, T., Carvalho, T., Prinz, I., & Ribot, J. C. (2020). Microbiota-dependent expansion of testicular IL-17-producing Vγ6 + γδ T cells upon puberty promotes local tissue immune surveillance. Mucosal Immunology, 1–11. https://doi.org/10.1038/s41385-020-0330-6Cite