KRAS

[Translational Oncology] Researchers developed a new PAK4 inhibitor, PAKib and tested its effect on pancreatic cancer (PC) cell growth in vitro and in a syngeneic mouse model of PC.

[Gastroenterology] Cell lines were isolated from Ptf1a-Cre;LSL-KrasG12D;Rnf43flox/flox and Ptf1a-Cre; LSL-KrasG12D tumors and interrogated by cytokine array analyses, ATAC-seq and in vitro drug assays.

[Proceedings of the National Academy of Sciences of the United States of America] Researchers showed that the phosphatidylserine (PtdSer) lipid transport proteins, ORP5 and ORP8, which are essential for maintaining plasma membrane (PM) PtdSer levels and hence KRAS PM localization, were required for KRAS oncogenesis.

[Cancer Biology & Therapy] C-Myc overexpression is a common finding in pancreatic cancer and predicts the aggressive behavior of cancer cells. It binds to the promoter of different genes, thereby regulating their transcription.

[Cancer Cell] The authors performed proteogenomic characterization of intrahepatic cholangiocarcinoma using paired tumor and adjacent liver tissues from 262 patients.

[Oncogene] Researchers demonstrate that lung adenocarcinoma was suppressed in oncogenic KrasG12D-driven mouse models engineered for pS727-STAT3 deficiency.