Components of the Phosphatidylserine Endoplasmic Reticulum to Plasma Membrane Transport Mechanism as Targets for KRAS Inhibition in Pancreatic Cancer

Researchers showed that the phosphatidylserine (PtdSer) lipid transport proteins, ORP5 and ORP8, which are essential for maintaining plasma membrane (PM) PtdSer levels and hence KRAS PM localization, were required for KRAS oncogenesis.