Combined MEK/MDM2 Inhibition Demonstrates Antitumor Efficacy in TP53 Wild-Type Thyroid and Colorectal Cancers with MAPK Alterations

Researchers evaluated combination therapy with MEK inhibitor selumetinib and MDM2 inhibitor KRT-232 in TP53 wild-type and mitogen-activated protein kinase (MAPK) altered colon and thyroid cancer models.
[Scientific Reports]
[zotpress userid=” items=’SPXSDFJC’ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share

Antiphospholipid Antibodies Increase Endometrial Stromal Cell Decidualization, Senescence and Inflammation via TLR4, ROS and p38 MAP Kinase Signaling

Antiphospholipid autoantibodies increased human endometrial stromal cell decidualization, senescence and inflammation. The decidualization and inflammatory responses were partially mediated by toll-like receptor 4 (TLR4) and p38 MAP kinase, while the decidualization and senescence responses were reactive oxygen species (ROS)-dependent.
[Arthritis & Rheumatology]
[zotpress userid=’7992332′ items=’BBBBBBBB’ style=’apa’ cite=’yes’]
Abstract
Bookmark

No account yet? Register

Share

MicroRNA-181a–2–3p Shuttled by Mesenchymal Stem Cell-Secreted Extracellular Vesicles Inhibits Oxidative Stress in Parkinson’s Disease by Inhibiting EGR1 and NOX4

Researchers investigated the physiological mechanisms by which extracellular vesicle-encapsulated miR-181a–2–3p derived from MSCs might mediate oxidative stress in Parkinson’s disease
[Cell Death Discovery]
[zotpress userid=’7992332′ items=’BBBBBBBB’ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share

CIC-Mediated Modulation of MAPK Signaling Opposes Receptor Tyrosine Kinase Inhibitor Response in Kinase-Addicted Sarcoma

Scientists generated models of sarcomas bearing kinase fusions and assessed their response to molecularly targeted therapy. Immortalized, untransformed human MSCs, a putative cell-of-origin of sarcomas, were modified using CRISPR-Cas9 to harbor a RET chromosomal translocation.
[Cancer Research]
[zotpress userid=’7992332′ items=’BBBBBBBB’ style=’apa’ cite=’yes’]
AbstractFull Article
Bookmark

No account yet? Register

Share

XP-524 Is a Dual-BET/EP300 Inhibitor That Represses Oncogenic KRAS and Potentiates Immune Checkpoint Inhibition in Pancreatic Cancer

Researchers demonstrated that the multispecificity BET/EP300 inhibitor XP-524 has pronounced single-agent efficacy in vitro, in vivo, and ex vivo human PDAC slice cultures, functioning in part by attenuating oncogenic KRAS signaling.
[Proceedings of the National Academy of Sciences of the United States of America]
[zotpress userid=” items=’AAAAAAAA’ style=’apa’ cite=’yes’]
Abstract
Bookmark

No account yet? Register

Share

Antioxidation of a Proteoglycan from Ganoderma lucidum Protects Pancreatic β-Cells against Oxidative Stress-Induced Apoptosis In Vitro and In Vivo

Researchers investigated systematically the roles of a proteoglycan from Ganoderma lucidum in protection and repair of pancreatic β-cells against oxidative stress-induced injury and apoptosis on molecular, cellular and animal basis.
[International Journal of Biological Macromolecules]
[zotpress userid=” items=’AAAAAAAA’ style=’apa’ cite=’yes’]
Abstract
Bookmark

No account yet? Register

Share

Novel Inhibitor of Hematopoietic Cell Kinase as a Potential Therapeutic Agent for Acute Myeloid Leukemia

Scientists investigated in vitro, ex vivo and in vivo effects of a novel chemical compound targeting HCK inhibition, in combination with the most used drugs for the treatment of myelodysplastic syndrome and de novo acute myeloid leukemia, 5-Azacytidine and Cytarabine.
[Cancer Immunology Immunotherapy]
[zotpress userid=’7992332′ items=’BBBBBBBB’ style=’apa’ cite=’yes’]
Abstract
Bookmark

No account yet? Register

Share

Endometrial Stromal Cell Ferroptosis Promotes Angiogenesis in Endometriosis

Scientists revealed that endometrial stromal cell ferroptosis in the ovarian endometrioma may have triggered cytokine secretion and promoted angiogenesis of adjacent lesions via paracrine actions to drive the development of endometriosis.
[Cell Death Discovery]
[zotpress userid=’7992332′ items=’AAAAAAAA’ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share

Focal Adhesion Kinase Plays a Dual Role in TRAIL Resistance and Metastatic Outgrowth of Malignant Melanoma

The authors showed 2nd generation hexameric TRAIL-receptor-agonist IZI1551 to effectively induce apoptosis in malignant melanoma cells irrespective of the intrinsic BRAF/NRAS mutation status.
[Cell Death & Disease]
[zotpress userid=” items=’AAAAAAAA’ style=’apa’ cite=’yes’]
Full Article
Bookmark

No account yet? Register

Share

MAPK p38/Ulk1 Pathway Inhibits Autophagy and Induces IL-1β Expression in Hepatic Stellate Cells

Investigators revealed a continuous signaling pathway, MAPK p38-Ulk1 phosphorylation-Ulk1/Atg13 disruption, which inhibited autophagy and induced IL-1β expression in hepatic stellate cells.
[American Journal of Physiology-Gastrointestinal and Liver Physiology]
[zotpress userid=’7992332′ items=’EEEEEEEE’ style=’apa’ cite=’yes’]
Abstract
Bookmark

No account yet? Register

Share

LncRNA MEG3 Ameliorates NiO Nanoparticles-Induced Pulmonary Inflammatory Damage via Suppressing the p38 Mitogen Activated Protein Kinases Pathway

Wistar rats were treated with nickel oxide nanoparticles (NiO NPs) suspensions by intratracheal instillation twice-weekly for nine weeks. A549 cells were treated with NiO NPs suspensions for 24 hour.
[Environmental Toxicology]
[zotpress userid=” items=’SPXSDFJC’ style=’apa’ cite=’yes’]
Abstract
Bookmark

No account yet? Register

Share
Share