Tag Archives: MAPK

Phosphorylation of Msx1 Promotes Cell Proliferation through the Fgf9/18-MAPK Signaling Pathway during Embryonic Limb Development

Scientists demonstrated that Msh homeobox (Msx)1 promoted the proliferation of myoblasts and MSCs by enhancing mitogen-activated protein kinase (MAPK) signaling.
[Nucleic Acids Research]
Yang, Y., Zhu, X., Jia, X., Hou, W., Zhou, G., Ma, Z., Yu, B., Pi, Y., Zhang, X., Wang, J., & Wang, G. (n.d.). Phosphorylation of Msx1 promotes cell proliferation through the Fgf9/18-MAPK signaling pathway during embryonic limb development. Nucleic Acids Research. https://doi.org/10.1093/nar/gkaa905 Cite
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Decellularized Extracellular Matrix Scaffolds Identify Full-Length Collagen VI as a Driver of Breast Cancer Cell Invasion in Obesity and Metastasis

The authors describe a method to study whole-tissue extracellular matrix (ECM) effects from disease states associated with metastasis on tumor cell phenotypes and identified the individual ECM proteins and signaling pathways that were driving these effects. They showed that decellularized ECM from tumor-bearing and obese mammary glands drives TNBC cell invasion.
[Science Advances]
Decellularized extracellular matrix scaffolds identify full-length collagen VI as a driver of breast cancer cell invasion in obesity and metastasis | Science Advances. (n.d.). Retrieved October 21, 2020, from https://advances.sciencemag.org/content/6/43/eabc3175 Cite
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Phosphorylation of Msx1 Promotes Cell Proliferation through the Fgf9/18-MAPK Signaling Pathway during Embryonic Limb Development

Investigators demonstrated that Msh homeobox 1 (Msx1) promotes the proliferation of myoblasts and mesenchymal stem cells by enhancing mitogen-activated protein kinase (MAPK) signaling.
[Nucleic Acids Research]
Yang, Y., Zhu, X., Jia, X., Hou, W., Zhou, G., Ma, Z., Yu, B., Pi, Y., Zhang, X., Wang, J., & Wang, G. (n.d.). Phosphorylation of Msx1 promotes cell proliferation through the Fgf9/18-MAPK signaling pathway during embryonic limb development. Nucleic Acids Research. https://doi.org/10.1093/nar/gkaa905 Cite
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Endothelial Dysfunction in Neuroprogressive Disorders- Causes and Suggested Treatments

On the basis of the above molecular mechanisms, details are given of potential treatment options for mitigating endothelial cell dysfunction and activation in neuroprogressive disorders.
[BMC Medicine]
Morris, G., Puri, B. K., Olive, L., Carvalho, A., Berk, M., Walder, K., Gustad, L. T., & Maes, M. (2020). Endothelial dysfunction in neuroprogressive disorders—causes and suggested treatments. BMC Medicine, 18(1), 305. https://doi.org/10.1186/s12916-020-01749-w Cite
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ERK3/MAPK6 Is Required for KRAS-Mediated NSCLC Tumorigenesis

Investigators uncovered that ERK3, a ubiquitously expressed atypical MAPK, was required for KRAS-mediated NSCLC tumors. ERK3 is highly expressed in lung cancers, and oncogenic KRAS led to the activation and stabilization of the ERK3 protein.
[Cancer Gene Therapy]
Bogucka, K., Marini, F., Rosigkeit, S., Schloeder, J., Jonuleit, H., David, K., Schlackow, M., & Rajalingam, K. (2020). ERK3/MAPK6 is required for KRAS-mediated NSCLC tumorigenesis. Cancer Gene Therapy, 1–16. https://doi.org/10.1038/s41417-020-00245-w Cite
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Siah2 Integrates Mitogenic and Extracellular Matrix Signals Linking Neuronal Progenitor Ciliogenesis with Germinal Zone Occupancy

Researchers determined that the Siah2 E3 ubiquitin ligase functions in a coincidence detection circuit linking responses to the Shh mitogen and the ECM to control cerebellar granule neurons germinal zone occupancy.
[Nature Communications]
Ong, T., Trivedi, N., Wakefield, R., Frase, S., & Solecki, D. J. (2020). Siah2 integrates mitogenic and extracellular matrix signals linking neuronal progenitor ciliogenesis with germinal zone occupancy. Nature Communications, 11(1), 5312. https://doi.org/10.1038/s41467-020-19063-7 Cite
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Extracellular Matrix-Bound FGF2 Mediates Estrogen Receptor Signaling and Therapeutic Response in Breast Cancer

Scientists uncovered that estrogen receptor-positive breast cancer cells cultured within extracellular matrix -scaffolds had an increase in ER signaling that occured via a MAPK-dependent, but estrogen-independent manner.
[Molecular Cancer Research]
DiGiacomo, J. W., Godet, I., Trautmann-Rodriguez, M., & Gilkes, D. M. (2020). Extracellular matrix-bound FGF2 mediates estrogen receptor signaling and therapeutic response in breast cancer. Molecular Cancer Research. https://doi.org/10.1158/1541-7786.MCR-20-0554 Cite
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Neurotensin Receptor 1 Signaling Promotes Pancreatic Cancer Progression

Investigators used sublines to screen molecular targets for the treatment of pancreatic cancer. Among the genes with increased expression levels in the sublines, they focused on those encoding cell surface receptors that may be involved in the interactions between cancer cells and the tumor microenvironment.
[Molecular Oncology]
Takahashi, K., Ehata, S., Miyauchi, K., Morishita, Y., Miyazawa, K., & Miyazono, K. (n.d.). Neurotensin receptor 1 signaling promotes pancreatic cancer progression. Molecular Oncology, n/a(n/a). https://doi.org/10.1002/1878-0261.12815 Cite
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Calreticulin Promotes EMT in Pancreatic Cancer via Mediating Ca2+ Dependent Acute and Chronic Endoplasmic Reticulum Stress

Researchers investigated the potential role and mechanism of calreticulin in regulating intracellular free Ca2+ dependent acute and chronic endoplasmic reticulum stress-induced epithelial-mesenchymal transition in pancreatic camcer in vitro and vivo.
[Journal of Experimental & Clinical Cancer Research]
Sheng, W., Wang, G., Tang, J., Shi, X., Cao, R., Sun, J., Lin, Y. H., Jia, C., Chen, C., Zhou, J., & Dong, M. (2020). Calreticulin promotes EMT in pancreatic cancer via mediating Ca2+ dependent acute and chronic endoplasmic reticulum stress. Journal of Experimental & Clinical Cancer Research, 39(1), 209. https://doi.org/10.1186/s13046-020-01702-y Cite
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ARHGEF19 Regulates MAPK/ERK Signaling and Promotes the Progression of Small Cell Lung Cancer

Enforced ARHGEF19 expression promotes small cell lung cancer cell proliferation in vitro and its knockdown decreases cell proliferation in vitro and in vivo.
[Biochemical and Biophysical Research Communications]
Wang, Z., Kan, G., Sheng, C., Yao, C., Mao, Y., & Chen, S. (2020). ARHGEF19 regulates MAPK/ERK signaling and promotes the progression of small cell lung cancer. Biochemical and Biophysical Research Communications. https://doi.org/10.1016/j.bbrc.2020.09.085 Cite
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LncRNA LL22NC03-N14H11.1 Promoted Hepatocellular Carcinoma Progression through Activating MAPK Pathway to Induce Mitochondrial Fission

Dysregulated lncRNAs in hepatocellular carcinoma (HCC) were identified through circlncRNAnet and GEPIA bioinformatics tools. Biological function of LL22NC03-N14H11.1 in HCC was detected by CCK-8 assay, flow cytometry analysis, transwell invasion, and wound healing assays.
[Cell Death & Disease]
Yi, T., Luo, H., Qin, F., Jiang, Q., He, S., Wang, T., Su, J., Song, S., Qin, X., Qin, Y., Zhou, X., & Huang, Z. (2020). LncRNA LL22NC03-N14H11.1 promoted hepatocellular carcinoma progression through activating MAPK pathway to induce mitochondrial fission. Cell Death & Disease, 11(10), 1–17. https://doi.org/10.1038/s41419-020-2584-z Cite
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