Tag Archives: MAPK

Prevention of Fibrosis and Pathological Cardiac Remodeling by Salinomycin

Scientists demonstrated that salinomycin displayed potent anti-fibrotic activity in cardiac fibroblasts obtained from heart failure patients. In pre-clinical studies, salinomycin prevented cardiac fibrosis and functional decline in mouse models of ischemic and non-ischemic heart disease.
[Circulation Research]
Burke Ryan M, Dirkx, Jr. R. A., Quijada Pearl, Lighthouse Janet K, Mohan Amy, O’Brien Meghann, Wojciechowski Wojciech, Woeller Collynn, Phipps Richard P, Alexis Jeffrey D, Ashton John, & Small Eric M. (n.d.). Prevention of Fibrosis and Pathological Cardiac Remodeling by Salinomycin. Circulation Research, 0(0). https://doi.org/10.1161/CIRCRESAHA.120.317791 Cite
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Myeloid Cell–Derived HOCl Is a Paracrine Effector That Trans-inhibits IKK/NF-κB in Melanoma Cells and Limits Early Tumor Progression

Investigators revealed a role for myeloid-derived cells-derived hypochlorous acid (HOCl) as a small-molecule paracrine signaling factor that trans-inhibited inhibited IκB kinase (IKK) in melanoma tumor cells, mediating antitumor responses during early tumor progression.
[Science Signaling]
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Cellular and Molecular Mechanisms Breaking Immune Tolerance in Inborn Errors of Immunity

Scientists demonstrated that ZIP8 was specifically upregulated in CD4+ T cells that infiltrated the inflamed joint and that ZIP8 deficiency in CD4+ T cells abrogated collagen-induced arthritis.
[Experimental & Molecular Medicine]
Sogkas, G., Atschekzei, F., Adriawan, I. R., Dubrowinskaja, N., Witte, T., & Schmidt, R. E. (2021). Cellular and molecular mechanisms breaking immune tolerance in inborn errors of immunity. Cellular & Molecular Immunology, 1–19. https://doi.org/10.1038/s41423-020-00626-z Cite
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Quantifying Single-Cell ERK Dynamics in Colorectal Cancer Organoids Reveals EGFR as an Amplifier of Oncogenic MAPK Pathway Signaling

To elucidate the interplay between epidermal growth factor signaling and extracellular-regulated kinase activation in tumors, scientists used patient-derived organoids from KRAS and BRAF mutant colorectal cancer.
[Nature Cell Biology]
Ponsioen, B., Post, J. B., Buissant des Amorie, J. R., Laskaris, D., van Ineveld, R. L., Kersten, S., Bertotti, A., Sassi, F., Sipieter, F., Cappe, B., Mertens, S., Verlaan-Klink, I., Boj, S. F., Vries, R. G. J., Rehmann, H., Vandenabeele, P., Riquet, F. B., Trusolino, L., Bos, J. L., & Snippert, H. J. G. (2021). Quantifying single-cell ERK dynamics in colorectal cancer organoids reveals EGFR as an amplifier of oncogenic MAPK pathway signalling. Nature Cell Biology, 1–14. https://doi.org/10.1038/s41556-021-00654-5 Cite
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c-Jun N-terminal kinase 1 (JNK1) Modulates Oligodendrocyte Progenitor Cell Architecture, Proliferation and Myelination

Myelin alterations are accompanied by higher oligodendrocyte progenitor cell (OPC) density and proliferation during the first weeks of life, consistent with a transient alteration of mechanisms regulating OPC self-renewal and differentiation.
[Scientific Reports]
Lorenzati, M., Boda, E., Parolisi, R., Bonato, M., Borsello, T., Herdegen, T., Buffo, A., & Vercelli, A. (2021). c-Jun N-terminal kinase 1 (JNK1) modulates oligodendrocyte progenitor cell architecture, proliferation and myelination. Scientific Reports, 11(1), 7264. https://doi.org/10.1038/s41598-021-86673-6 Cite
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The Human Intermediate Prolactin Receptor Is a Mammary Proto-Oncogene

An analogous truncated mouse prolactin receptor (mPRLr) was found to be oncogenic when co-expressed with wild-type mPRLr. The authors determined if a similar transforming event occurs with the hPRLr in human breast epithelial cells.
[npj Breast Cancer]
Grible, J. M., Zot, P., Olex, A. L., Hedrick, S. E., Harrell, J. C., Woock, A. E., Idowu, M. O., & Clevenger, C. V. (2021). The human intermediate prolactin receptor is a mammary proto-oncogene. Npj Breast Cancer, 7(1), 1–11. https://doi.org/10.1038/s41523-021-00243-7 Cite
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Tumor Necrosis Factor‐α‐Induced Protein 8‐like 2 Alleviates Nonalcoholic Fatty Liver Disease via Suppressing TAK1 Activation

Tumor necrosis factor‐α‐induced protein 8‐like 2 suppressed nonalcoholic fatty liver disease (NAFLD) advancement by blocking transforming growth factor‐beta‐activated kinase 1‐c‐Jun NH2‐terminal kinase/p38 pathway and was a promising target molecule for NAFLD therapy.
[Hepatology]
Liu, Y., Song, J., Yang, J., Zheng, J., Yang, L., Gao, J., Tian, S., Liu, Z., Meng, X., Wang, J.-C., Dai, Z., & Tang, Y.-D. (n.d.). Tumor necrosis factor-α-induced protein 8-like 2 alleviates nonalcoholic fatty liver disease via suppressing TAK1 activation. Hepatology, n/a(n/a). https://doi.org/https://doi.org/10.1002/hep.31832 Cite
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SWATH-MS Proteomics of PANC-1 and MIA PaCa-2 Pancreatic Cancer Cells Allows Identification of Drug Targets Alternative to MEK and PI3K Inhibition

Scientists compared PANC-1 and MIA PaCa-2 pancreatic cancer cells which are, respectively, resistant and sensitive to MEK- and PI3K-targeted therapy.
[Biochemical and Biophysical Research Communications]
Aguilar-Valdés, A., Noriega, L. G., Tovar, A. R., Ibarra-Sánchez, M. de J., Sosa-Hernández, V. A., Maravillas-Montero, J. L., & Martínez-Aguilar, J. (2021). SWATH-MS proteomics of PANC-1 and MIA PaCa-2 pancreatic cancer cells allows identification of drug targets alternative to MEK and PI3K inhibition. Biochemical and Biophysical Research Communications, 552, 23–29. https://doi.org/10.1016/j.bbrc.2021.03.018 Cite
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Dasatinib Stimulates Its Own Mechanism of Resistance by Activating a CRTC3/MITF/Bcl-2 Pathway in Melanoma with Mutant or Amplified C-Kit

Researchers showed that, dasatinib in melanoma stimulated its proper mechanism of resistance, independently of MAPK and PI3K/AKT pathway reactivation commonly associated to secondary c-Kit mutations, but through CRTC3/MITF/Bcl-2 pathway activation at clinically relevant doses.
[Molecular Cancer Research]
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Extracellular Vesicles from Human Airway Basal Cells Respond to Cigarette Smoke Extract and Affect Vascular Endothelial Cells

Researchers showed that exposure of endothelial cells to exosome-enriched airway basal cell extracellular vesicles (EVs) promoted the survival of these cells and that this effect also involved VEGFR2 activation and is, at least in part, mediated by VEGFA present in the EVs.
[Scientific Reports]
Saxena, A., Walters, M. S., Shieh, J.-H., Shen, L.-B., Gomi, K., Downey, R. J., Crystal, R. G., & Moore, M. A. S. (2021). Extracellular vesicles from human airway basal cells respond to cigarette smoke extract and affect vascular endothelial cells. Scientific Reports, 11(1), 6104. https://doi.org/10.1038/s41598-021-85534-6 Cite
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Tectoridin Inhibits the Progression of Colon Cancer through Downregulating PKC/p38 MAPK Pathway

Colon cancer cell lines were treated with different doses of tectoridin, Then, CCK8 and clone formation experiments were performed to detect cell proliferation.
[Molecular and Cellular Biochemistry]
Xiong, L., Guo, W., Yang, Y., Gao, D., Wang, J., Qu, Y., & Zhang, Y. (2021). Tectoridin inhibits the progression of colon cancer through downregulating PKC/p38 MAPK pathway. Molecular and Cellular Biochemistry. https://doi.org/10.1007/s11010-021-04081-w Cite
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