Aberrant bone marrow-M1/M2 MФ polarization, characterized by increased M1 MФs and decreased M2 MФs and accompanied by impaired megakaryopoiesis-supporting abilities, was found in patients with thrombocytopenia post-allotransplant.
[Signal Transduction and Targeted Therapy]
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Scientists found that acrolein induced oncogenic transformation, including faster cell cycling, proliferation, sphere formation and cell migration, in fibroblast cells, and acrolein-induced DNA damages were higher in colorectal cancer (CRC) tumor tissues than in normal epithelial cells in CRC patients.
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Examining human specimens from free myocutaneous flap transfer demonstrated increased myostatin signaling and tissue damage in terms of apoptotic activity, cell death, tissue edema, and lipid peroxidation.
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The authors reported that cabozantinib could promote differentiation in erythroid leukemia cells and found that K562 erythroid leukemia cells treated with 1 μM cabozantinib for 72 hours underwent erythroid lineage differentiation.
[Cancer Gene Therapy]
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Investigators discovered that FLT3-ITD, one of the most frequent mutations in acute myeloid leukemia, was S-palmitoylated by the ZDHHC6 palmitoyl acyltransferase. Disruption of palmitoylation redirected FLT3-ITD to the plasma membrane and rewired its downstream signaling by activating AKT and ERK pathways in addition to STAT5.
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The proximal colonic tumors that developed in a mouse model of right-sided colon cancer exhibited a fetal-like progenitor phenotype (Ly6a/Sca1+) and lacked expression of Lgr5 and its associated intestinal stem cell signature.
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Scientists used quantitative mass spectrometry to characterize intrinsic changes in the muscle stem cell (MuSC) proteome and remodeling of the MuSC niche during aging.
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In addition to impacting stem cell proliferation during damage-induced intestinal regeneration, the role of RAL GTPases impacted on EGFR-dependent tumorigenic growth in the intestine and in human mammary epithelium.
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The upregulated gonadotropin-releasing hormone (GnRH) expression in GT1-7 GnRH neuronal cells induced by the 5-HT receptor 1A (HTR1A) antagonist WAY-100635 maleate was observed in vitro.
[Molecular Therapy-Nucleic Acids]
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Investigators assessed the anti-tumor effects of probiotic bacteria against pancreatic cancer cells. Among the known probiotic bacteria, Aspergillus oryzae exhibited a strong pancreatic tumor suppression effect.
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Konishi, H., Isozaki, S., Kashima, S., Moriichi, K., Ichikawa, S., Yamamoto, K., Yamamura, C., Ando, K., Ueno, N., Akutsu, H., Ogawa, N., & Fujiya, M. (2021). Probiotic Aspergillus oryzae produces anti-tumor mediator and exerts anti-tumor effects in pancreatic cancer through the p38 MAPK signaling pathway. Scientific Reports, 11(1), 11070. https://doi.org/10.1038/s41598-021-90707-4 Cite
Researchers explored the molecular mechanisms of PNO1 in hepatocellular carcinoma.
[Cell Death & Disease]
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Han, Z., Liu, D., Chen, L., He, Y., Tian, X., Qi, L., Chen, L., Luo, Y., Chen, Z., Hu, X., Li, G., Zhan, L., Wang, Y., Li, Q., Chen, P., Liu, Z., & Guo, H. (2021). PNO1 regulates autophagy and apoptosis of hepatocellular carcinoma via the MAPK signaling pathway. Cell Death & Disease, 12(6), 1–14. https://doi.org/10.1038/s41419-021-03837-y Cite