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Presenilin 2 N141I Mutation Induces Hyperactive Immune Response through the Epigenetic Repression of REV-ERBα

[Nature Communications] Researchers investigated how an Alzheimer's disease-linked mutation deregulated expression of circadian genes and induced cognitive decline using the knock-in mice heterozygous for presenilin 2 N141I mutation.

Fraxetin Down-Regulates Polo-Like Kinase 4 (PLK4) to Inhibit Proliferation, Migration and Invasion of Prostate Cancer Cells through the Phosphatidylinositol 3-Kinase (PI3K)/Protein Kinase B (Akt)...

[Bioengineered] The prostatic epithelial cell RWPE-1 and prostate cancer cell DU145 were exposed to Fraxetin to detect the changes in cell viability using cell counting kit-8 assay.

The miR-4732-5p/XPR1 Axis Suppresses the Invasion, Metastasis, and Epithelial–Mesenchymal Transition of Lung Adenocarcinoma via the PI3K/Akt/GSK3β/Snail Pathway

[Molecular Omics] Overexpression of miR-4732-5p significantly inhibited the migration, invasion, and metastasis of lung adenocarcinoma in vitro and in vivo, which could be reversed by overexpression of xenotropic and polytropic retrovirus receptor 1 (XPR1).

USP28 Enables Oncogenic Transformation of Respiratory Cells and Its Inhibition Potentiates Molecular Therapy Targeting Mutant EGFR, BRAF and PI3K.

[Molecular Oncology] Targeting ubiquitin carboxyl-terminal hydrolase 28 (USP28) protein abundance at an early stage via inhibition of its activity is a feasible strategy for the treatment of early-stage lung tumors.

TAL1 Cooperates with PI3K/AKT Pathway Activation in T-cell Acute Lymphoblastic Leukemia

[Haematologica] Scientists investigated the oncogenic function of TAL1 and the possible cooperation with PI3K-AKT pathway activation using isogenic pro-T cell cultures ex vivo and in vivo leukemia models.

Low-Temperature Plasma-Activated Medium Inhibited Proliferation and Progression of Lung Cancer by Targeting the PI3K/Akt and MAPK Pathways

[Oxidative Medicine and Cellular Longevity] Scientists explored the effect of the plasma-activated medium on lung cancer cells in vitro and in vivo by using a 3D cell culture model.