Antagonists of the Serotonin Receptor 5A Target Human Breast Tumor Initiating Cells

Researchers found that selective antagonists of 5-HT5A reduced the frequency of tumorsphere initiating cells residing in breast tumor cell lines and those of patient-derived xenografts that they established.
[BMC Cancer]
Gwynne, W. D., Shakeel, M. S., Girgis-Gabardo, A., Kim, K. H., Ford, E., Dvorkin-Gheva, A., Aarts, C., Isaac, M., Al-awar, R., & Hassell, J. A. (2020). Antagonists of the serotonin receptor 5A target human breast tumor initiating cells. BMC Cancer, 20(1), 724. https://doi.org/10.1186/s12885-020-07193-6 Cite
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Reduced Mrp2 Surface Availability as PI3Kγ-Mediated Hepatocytic Dysfunction Reflecting a Hallmark of Cholestasis in Sepsis

Keeping the surface availability of the biliary transporter Mrp2 is a cell biological process that may underlie the observation that PI3Kγ loss-of-function protects from hepatic excretory dysfunction during early sepsis
[Scientific Reports]
Beer, A. J., Hertz, D., Seemann, E., Beretta, M., Westermann, M., Bauer, R., Bauer, M., Kessels, M. M., & Qualmann, B. (2020). Reduced Mrp2 surface availability as PI3Kγ-mediated hepatocytic dysfunction reflecting a hallmark of cholestasis in sepsis. Scientific Reports, 10(1), 13110. https://doi.org/10.1038/s41598-020-69901-3 Cite
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Quercetin–Resveratrol Combination for Prostate Cancer Management in TRAMP Mice

Scientists determined the effects of grape antioxidants quercetin and/or resveratrol against prostate cancer in the transgenic adenocarcinoma of mouse prostate (TRAMP)-model in prevention and intervention settings.
[Cancers]
Singh, C. K., Chhabra, G., Ndiaye, M. A., Siddiqui, I. A., Panackal, J. E., Mintie, C. A., & Ahmad, N. (2020). Quercetin–Resveratrol Combination for Prostate Cancer Management in TRAMP Mice. Cancers, 12(8), 2141. https://doi.org/10.3390/cancers12082141 Cite
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Inhibition of Protein Kinase D by CID755673 Promotes Maintenance of the Pluripotency of Embryonic Stem Cells

Investigators showed that the protein kinase D inhibitor CID755673 was able to maintain the undifferentiated state of mouse ESCs in combination with the mitogen-activated protein kinase kinase inhibitor.
[Development]
Zhu, Z., Zhang, Y., Wang, X., Wang, X., & Ye, S.-D. (2020). Inhibition of protein kinase D by CID755673 promotes maintenance of the pluripotency of embryonic stem cells. Development. https://doi.org/10.1242/dev.185264 Cite
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Unique Targeting of Androgen‐Dependent and ‐Independent AR Signaling in Prostate Cancer to Overcome Androgen Resistance

The authors investigated the ability of novel anti‐cancer agents, Dp44mT and DpC, to overcome androgen resistance. The effect of Dp44mT and DpC on androgen‐dependent and independent androgen receptor signaling was assessed in androgen‐dependent and ‐independent prostate cancer cells using 2D‐ and 3D‐tissue culture.
[FASEB Journal]
Lim, S. C., Jansson, P. J., Assinder, S. J., Maleki, S., Richardson, D. R., & Kovacevic, Z. (n.d.). Unique targeting of androgen-dependent and -independent AR signaling in prostate cancer to overcome androgen resistance. The FASEB Journal, n/a(n/a). https://doi.org/10.1096/fj.201903167R Cite
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Oncogenic Smurf1 Promotes PTEN Wild-Type Glioblastoma Growth by Mediating PTEN Ubiquitylation

Smurf1 promotes cell growth and colony formation by accelerating cell cycle and aberrant signaling pathways. In addition, the authors showed that Smurf1 ubiquitylates and degrades phosphatase and tensin homolog.
[Oncogene]
Xia, Q., Zhang, H., Zhang, P., Li, Y., Xu, M., Li, X., Li, X., & Dong, L. (2020). Oncogenic Smurf1 promotes PTEN wild-type glioblastoma growth by mediating PTEN ubiquitylation. Oncogene, 1–14. https://doi.org/10.1038/s41388-020-01400-1 Cite
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Progesterone Receptor Membrane Component 1 Promotes the Growth of Breast Cancers by Altering the Phosphoproteome and Augmenting EGFR/PI3K/AKT Signalling

Investigators demonstrated that progesterone receptor membrane component 1 played a prominent role in regulating the growth of cancer cells by altering the PI3K/AKT/mTOR and EGFR signalling mechanisms in both ER-positive and TNBC cells.
[British Journal of Cancer]
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Osteogenic Cocktail Induces Calcifications in Human Breast Cancer Cell Line via Placental Alkaline Phosphatase Expression

The authors found that breast cancer cells acquired alkaline phosphatase enzyme activity via placental alkaline phosphatase expression and suggested that breast calcification formation was closely associated with the PI3K-Akt signaling pathway.
[Scientific Reports]
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Activating PIK3CA Mutation Promotes Adipogenesis of Adipose-Derived Stem Cells in Macrodactyly via Up-Regulation of E2F1

PIK3CA (H1047R) Activating Mutation and Enhanced Activity of PI3K/AKT Pathway were Detected in Macrodactylous Adipose-Derived Stem Cells (Mac-ADSCs).
[Cell Death & Disease]
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Anlotinib Suppresses Tumor Progression via Blocking the VEGFR2/PI3K/Akt Cascade in Intrahepatic Cholangiocarcinoma

Using in vitro experiments, investigators found that anlotinib had significant effects on proliferation inhibition, migration and invasion restraint, and cell-cycle arrestment in intrahepatic cholangiocarcinoma.
[Cell Death & Disease]
Song, F., Hu, B., Cheng, J.-W., Sun, Y.-F., Zhou, K.-Q., Wang, P.-X., Guo, W., Zhou, J., Fan, J., Chen, Z., & Yang, X.-R. (2020). Anlotinib suppresses tumor progression via blocking the VEGFR2/PI3K/AKT cascade in intrahepatic cholangiocarcinoma. Cell Death & Disease, 11(7), 1–14. https://doi.org/10.1038/s41419-020-02749-7 Cite
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SOX2 and p53 Expression Control Converges in PI3K/AKT Signaling with Versatile Implications for Stemness and Cancer

The authors summarize the latest advances in the understanding of PI3K/AKT/SOX2-driven stemness and its intertwined relations to p53-signaling in DNA damage response under conditions of pluripotency, reprogramming, and transformation.
[International Journal of Molecular Sciences]
Schaefer, T., Steiner, R., & Lengerke, C. (2020). SOX2 and p53 Expression Control Converges in PI3K/AKT Signaling with Versatile Implications for Stemness and Cancer. International Journal of Molecular Sciences, 21(14), 4902. https://doi.org/10.3390/ijms21144902 Cite
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PRDM15 Is a Key Regulator of Metabolism Critical to Sustain B-Cell Lymphomagenesis

Investigators demonstrated that while PRDM15 was largely dispensable for mouse adult somatic cell homeostasis in vivo, it played a critical role in B-cell lymphomagenesis.
[Nature Communications]
Mzoughi, S., Fong, J. Y., Papadopoli, D., Koh, C. M., Hulea, L., Pigini, P., … Guccione, E. (2020). PRDM15 is a key regulator of metabolism critical to sustain B-cell lymphomagenesis. Nature Communications, 11(1), 3520. https://doi.org/10.1038/s41467-020-17064-0 Cite
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