Dual Akt and Bcl-2 Inhibition Induces Cell-Type Specific Modulation of Apoptotic and Autophagic Signaling in Castration Resistant Prostate Cancer Cell Lines

The authors elucidated the modulation patterns between apoptosis and autophagy following dual inhibition by Akt inhibitor erufosine and Bcl-2 inhibitor ABT-737 in castration-resistant prostate cancer cell lines, PC-3 (Bax+) and DU-145 (Bax−).
[Molecular Biology Reports]
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SDF-1 Secreted by Mesenchymal Stem Cells Promotes the Migration of Endothelial Progenitor Cells via CXCR4/PI3K/AKT Pathway

The authors investigated whether stromal cell-derived factor (SDF)-1 secreted by mesenchymal stem cells contributed to endothelial progenitor cell migration to ischemic sites via CXCR4/Phosphoinositide 3-Kinases/protein kinase B signaling pathway.
[Journal of Molecular Histology]
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Potentiated Lung Adenocarcinoma (LUAD) Cell Growth, Migration and Invasion by lncRNA DARS-AS1 via miR-188-5p/ KLF12 Axis

Cell functional experiments revealed that lncRNA DARS-AS1 participated in enhancing lung adenocarcinoma proliferation, invasion, and migration by inhibiting miR-188-5p.
[Aging]
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Rhizen Pharmaceuticals AG Announces First Patient Dosing in a Phase II Study of Tenalisib (RP6530) in Locally Advanced or Metastatic Breast Cancer Patients

Rhizen Pharmaceuticals AG announced that it has commenced dosing in a Phase II trial to evaluate Tenalisib in patients with locally advanced or metastatic breast cancer.
[Rhizen Pharmaceuticals (BusinessNewsWire, Inc.)]
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Evolution of MET and NRAS Gene Amplification as Acquired Resistance Mechanisms in EGFR Mutant NSCLC

A patient-derived cell line obtained at the time of disease progression was used to identify NRAS gene amplification as an additional driver of drug resistance to combination EGFR/MET therapies.
[npj Precision Oncology]
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ECHS1, an Interacting Protein of LASP1, Induces Sphingolipid-Metabolism Imbalance to Promote Colorectal Cancer Progression by Regulating Ceramide Glycosylation

Through an LC–MS assay, LIM and SH3 protein 1 (LASP1) was identified as a sphingolipid-metabolism-involved protein, and short-chain enoyl-CoA hydratase (ECHS1) was identified as a new LASP1-interacting protein through a protein assay in colorectal cancer.
[Cell Death & Disease]
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CUL5-Mediated Visfatin (NAMPT) Degradation Blocks Endothelial Proliferation and Angiogenesis via the MAPK/PI3K-AKT Signaling

Researchers found that NAMPT overexpression protected human coronary artery endothelial cells from H2O2-induced injury through promoting cell viability, inhibiting cell apoptosis, enhancing cell motility, and promoting tube formation.
[Journal of Cardiovascular Pharmacology]
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PI3Kγδ Inhibitor plus Radiation Enhances the Antitumor Immune Effect of PD-1 Blockade in Syngenic Murine Breast Cancer and Humanized Patient-Derived Xenograft Model

Murine breast cancer cells were grown in both immune-competent and -deficient BALB/c mice, and tumors were irradiated by three fractions of 24 Gy. A PD-1 blockade and a phosphoinositide 3-kinase (PI3K)γδ inhibitor were then administered every other day for two weeks.
[European Journal of Cancer]
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The Importance of Endothelial Protection: The Emerging Role of Defibrotide in Reversing Endothelial Injury and Its Sequelae

Further preclinical and clinical studies will explore defibrotide’s potential utility in a broader range of disorders resulting from endothelial cell activation and dysfunction.
[Bone Marrow Transplantation]
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Tanshinone IIA Affects the Malignant Growth of Cholangiocarcinoma Cells by Inhibiting the PI3K-Akt-mTOR Pathway

The anti-cancer effects of Tanshinone IIA (Tan-IIA) were investigated by using subcutaneous tumorigenic model in nude mice and in the human cholangiocarcinoma cell lines in vitro. Tan-IIA treatment considerably suppressed the proliferation and migration of Cholangiocarcinoma cells while inducing apoptosis of Cholangiocarcinoma cells.
[Scientific Reports]
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Extracellular PKM2 Facilitates Organ-Tissue Fibrosis Progression

The authors reported that myofibroblasts expressed and secreted PKM2. Extracellular PKM2 upregulated arginase-1 expression in myofibroblasts, therefore facilitating proline biosynthesis and subsequent collagen production.
[iScience]
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