Pan-Cancer Analysis Reveals TAp63-Regulated Oncogenic lncRNAs that Promote Cancer Progression through AKT Activation

By performing a mouse-human cross species analysis between the TAp63 metastatic mammary adenocarcinoma mouse model and models of human breast cancer progression, researchers identified two TAp63-regulated oncogenic lncRNAs, TROLL-2 and TROLL-3.
[Nature Communications]
Napoli, M., Li, X., Ackerman, H. D., Deshpande, A. A., Barannikov, I., Pisegna, M. A., Bedrosian, I., Mitsch, J., Quinlan, P., Thompson, A., Rajapakshe, K., Coarfa, C., Gunaratne, P. H., Marchion, D. C., Magliocco, A. M., Tsai, K. Y., & Flores, E. R. (2020). Pan-cancer analysis reveals TAp63-regulated oncogenic lncRNAs that promote cancer progression through AKT activation. Nature Communications, 11(1), 5156. https://doi.org/10.1038/s41467-020-18973-w Cite
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WAVE3 Phosphorylation Regulates the Interplay between PI3K, TF-β, and EGF Signaling Pathways in Breast Cancer

Scientists showed that, in addition to PI3K, WAVE3 tyrosine phosphorylation could also be achieved downstream of TGF-β and EGF and that WAVE3 tyrosine phosphorylation was required for its oncogenic activity.
[Oncogenesis]
Wang, W., Kansakar, U., Markovic, V., Wang, B., & Sossey-Alaoui, K. (2020). WAVE3 phosphorylation regulates the interplay between PI3K, TGF-β, and EGF signaling pathways in breast cancer. Oncogenesis, 9(10), 1–13. https://doi.org/10.1038/s41389-020-00272-0 Cite
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Interleukin-6 Trans-Signaling Is a Candidate Mechanism to Drive Progression of Human DCCs During Clinical Latency

Investigators found PIK3CA mutations highly associated with late-stage metastatic cells while being extremely rare in early disseminated cancer cells (DCCs).
[Nature Communications]
Werner-Klein, M., Grujovic, A., Irlbeck, C., Obradović, M., Hoffmann, M., Koerkel-Qu, H., Lu, X., Treitschke, S., Köstler, C., Botteron, C., Weidele, K., Werno, C., Polzer, B., Kirsch, S., Gužvić, M., Warfsmann, J., Honarnejad, K., Czyz, Z., Feliciello, G., … Klein, C. A. (2020). Interleukin-6 trans-signaling is a candidate mechanism to drive progression of human DCCs during clinical latency. Nature Communications, 11(1), 4977. https://doi.org/10.1038/s41467-020-18701-4 Cite
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WAVE3 Phosphorylation Regulates the Interplay Between PI3K, TGF-β, and EGF Signaling Pathways in Breast Cancer

Investigators showed that, in addition to PI3K, WAVE3 tyrosine phosphorylation could also be achieved downstream of TGF-β and EGF and that WAVE3 tyrosine phosphorylation was required for its oncogenic activity.
[Oncogenesis]
Wang, W., Kansakar, U., Markovic, V., Wang, B., & Sossey-Alaoui, K. (2020). WAVE3 phosphorylation regulates the interplay between PI3K, TGF-β, and EGF signaling pathways in breast cancer. Oncogenesis, 9(10), 1–13. https://doi.org/10.1038/s41389-020-00272-0 Cite
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The Botanical Component p-Hydroxycinnamic Acid Suppresses the Growth and Bone Metastatic Activity of Human Prostate Cancer PC-3 Cells In Vitro

Scientists investigated the anticancer effects of botanical component p-hydroxycinnamic acid on the PC-3 cells in vitro model of bone metastatic human prostate cancer.
[Cancer Research]
Yamaguchi, M., Murata, T., & Ramos, J. W. (2020). The botanical component p-hydroxycinnamic acid suppresses the growth and bone metastatic activity of human prostate cancer PC-3 cells in vitro. Journal of Cancer Research and Clinical Oncology. https://doi.org/10.1007/s00432-020-03405-5 Cite
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Divergent Roles of PI3K Isoforms in PTEN-Deficient Glioblastomas

Researchers showed that PTEN-deficient glioblastomas largely depended on p110α for proliferation and p110β for migration.
[Cell Reports]
Xie, S., Ni, J., McFaline-Figueroa, J. R., Wang, Y., Bronson, R. T., Ligon, K. L., Wen, P. Y., Roberts, T. M., & Zhao, J. J. (2020). Divergent Roles of PI3K Isoforms in PTEN-Deficient Glioblastomas. Cell Reports, 32(13). https://doi.org/10.1016/j.celrep.2020.108196 Cite
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Ethionamide Preconditioning Enhances the Proliferation and Migration of Human Wharton’s Jelly-Derived Mesenchymal Stem Cells

Preconditioning with ethionamide promoted the proliferation of Wharton’s jelly-derived MSCs by activating phosphatidylinositol 3-kinase/Akt and mitogen-activated protein kinase/extracellular signal-regulated protein kinase kinase (MEK)/extracellular signal-regulated kinase 1/2 signaling.
[International Journal of Molecular Sciences]
Lee, N.-H., Myeong, S. H., Son, H. J., Hwang, J. W., Lee, N. K., Chang, J. W., & Na, D. L. (2020). Ethionamide Preconditioning Enhances the Proliferation and Migration of Human Wharton’s Jelly-Derived Mesenchymal Stem Cells. International Journal of Molecular Sciences, 21(19), 7013. https://doi.org/10.3390/ijms21197013 Cite
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A Novel β2-AR/YB-1/β-Catenin Axis Mediates Chronic Stress-Associated Metastasis in Hepatocellular Carcinoma

Investigators performed immunoprecipitation-mass spectrometry analysis of hepatocellular carcinoma (HCC) tissues. A vital oncoprotein, Y-box binding protein 1 (YB-1), was shown to interact with β2-adrenergic receptor (β2-AR) in HCC cells.
[Oncogenesis]
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PI3K/AKT Pathway as a Key Link Modulates the Multidrug Resistance of Cancers

The authors highlight the aberrant activation of PI3K/AKT as a key link that modulates multidrug resistance. They summarize the regulation of numerous major targets correlated with the PI3K/AKT pathway.
[Cell Death & Disease]
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Loss of Proprotein Convertase Furin in Mammary Gland Impairs proIGF1R and proIR Processing and Suppresses Tumorigenesis in Triple Negative Breast Cancer

Investigators report that Furin was frequently overexpressed in TNBC tumors and this correlated with poor prognosis in patients with TNBC tumors.
[Cancers]
He, Z., Khatib, A.-M., & Creemers, J. W. M. (2020). Loss of Proprotein Convertase Furin in Mammary Gland Impairs proIGF1R and proIR Processing and Suppresses Tumorigenesis in Triple Negative Breast Cancer. Cancers, 12(9), 2686. https://doi.org/10.3390/cancers12092686 Cite
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A Novel lncRNA LNC_000052 Leads to the Dysfunction of Osteoporotic BMSCs via the miR-96-5p–PIK3R1 Axis

The authors found that both LNC_000052 and PIK3R1 shared a miRNA target, miR-96-5p, which was downregulated in osteoporotic bone-marrow derived MSCs.
[Cell Death & Disease]
Li, M., Cong, R., Yang, L., Yang, L., Zhang, Y., & Fu, Q. (2020). A novel lncRNA LNC_000052 leads to the dysfunction of osteoporotic BMSCs via the miR-96-5p–PIK3R1 axis. Cell Death & Disease, 11(9), 1–13. https://doi.org/10.1038/s41419-020-03006-7 Cite
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