Tumor Microenvironment Acidity Triggers Lipid Accumulation in Liver Cancer via SCD1 Activation

Investigators found that the acidic tumor microenvironment contributed to lipid accumulation in liver cancer by activating the PI3K/AKT signaling pathway and promoting SCD1-PPARα binding.
[Molecular Cancer Research]
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HER2 Mediates PSMA/mGluR1-Driven Resistance to the DS-7423 Dual PI3K/mTOR Inhibitor in PTEN Wild-Type Prostate Cancer Models

Scientists investigated the response of PTEN wild-type prostate cancer cell lines to the dual PI3K/mTOR inhibitor DS-7423 alone or in combination with HER2 inhibitors or mGluR1 inhibitors.
[Molecular Cancer therapeutics]
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Breast Cancer Circulating Tumor Cells with Mesenchymal Features — an Unreachable Target?

The authors review the clinical significance of mesenchymal circulating tumor cells (CTCs) in breast cancer together with statistical analysis of previously published data, in which they assess the suitability of a number of methods/markers used for isolation of CTCs with different epithelial-mesenchymal transition phenotypes.
[Cellular and Molecular Life Sciences]
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Galectin-1 Confers Resistance to Doxorubicin in Hepatocellular Carcinoma Cells through Modulation of P-glycoprotein Expression

Researchers investigated the molecular mechanism underlying galectin-1-mediated chemoresistance in hepatocellular carcinoma cells, particularly the involvement of P-glycoprotein in this effect.
[Cell Death & Disease]
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Inhibition of MCL1 Induces Apoptosis in Anaplastic Large Cell Lymphoma and in Primary Effusion Lymphoma

To find additional hematologic entities with ectopic expression of BCL2 family members, investigators performed expression screening of cell lines applying the LL-100 panel.
[Scientific Reports]
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BRAF Inhibitors Reprogram Cancer-Associated Fibroblasts to Drive Matrix Remodeling and Therapeutic Escape in Melanoma

BRAF inhibitor induced BRAF-CRAF heterodimerization and subsequent activation of ERK signaling in cancer-associated fibroblasts, leading to inactivation of the β-catenin destruction complex.
[Cancer Research]
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Decursin Prevents Melanogenesis by Suppressing MITF Expression through the Regulation of PKA/CREB, MAPKs, and PI3K/Akt/GSK-3β Cascades

Decursin exhibited no cytotoxicity and significantly reduced intracellular tyrosinase activity and melanin content in B16F10 melanoma cells.
[Biomedicine & Pharmacotherapy]
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Oncogenic Potential of BEST4 in Colorectal Cancer via Activation of PI3K/Akt Signaling

BEST4 is a member of the bestrophin protein family that plays a critical role in human intestinal epithelial cells. Scientists investigated the role and clinical significance of BEST4 in CRC.
[Oncogene]
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Prostate Cancer Cell Proliferation Is Influenced by LDL-Cholesterol Availability and Cholesteryl Ester Turnover

As cholesterol is a key substrate for de novo steroidogenesis in prostate cells, researchers hypothesized that castrate-resistant/advanced prostate cancer cell growth was influenced by the availability of extracellular, low-density lipoprotein (LDL)-derived, cholesterol, which was coupled to intracellular cholesteryl ester homeostasis.
[Cancer & Metabolism]
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Updates on Breast Biomarkers

The authors cover the evolution and latest updates of the CAP/ASCO guidelines relevant to these two important biomarkers in breast cancer.
[Virchows Archiv]
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Sox9/CXCL5 Axis Facilitates Tumor Cell Growth and Invasion in Hepatocellular Carcinoma

Investigators observed that the increase of Sox9 significantly promoted hepatocellular carcinoma cell growth and invasion in cell cultures, whereas knockdown of Sox9 showed the opposite effects, suggesting that Sox9 may regulate the proliferation and invasion of hepatoma cells in an autocrine manner.
[FEBS Journal]
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