The AKT-Independent MET–V-ATPase–Mtor Axis Suppresses Liver Cancer Vaccination

Scientists investigated the regulatory effect and potential mechanism of hepatocyte growth factor receptor (MET, also known as HGFR) on tumor vaccinations for liver cancer in mice.
[Signal Transduction and Targeted Therapy]
Huang, X., Xu, X., Wang, X., Tang, T., Li, E., Zhang, X., Xu, J., Shen, H., Guo, C., Xu, T., Ren, J., Bai, X., & Liang, T. (2020). The AKT-independent MET–V-ATPase–MTOR axis suppresses liver cancer vaccination. Signal Transduction and Targeted Therapy, 5(1), 1–10. https://doi.org/10.1038/s41392-020-0179-x Cite
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Quantitative Evaluation of Protective Antibody Response Induced by Hepatitis E Vaccine in Humans

Vaccine-induced antibodies exhibited a high degree of clonal diversity, recognized five conformational antigenic sites of the genotype 1 HEV p239 antigen, and cross-reacted with other genotypes.
[Nature Communications]
Wen, G.-P., He, L., Tang, Z.-M., Wang, S.-L., Zhang, X., Chen, Y.-Z., Lin, X., Liu, C., Chen, J.-X., Ying, D., Chen, Z.-H., Wang, Y.-B., Luo, W.-X., Huang, S.-J., Li, S.-W., Zhang, J., Zheng, Z.-Z., Zhu, J., & Xia, N.-S. (2020). Quantitative evaluation of protective antibody response induced by hepatitis E vaccine in humans. Nature Communications, 11(1), 3971. https://doi.org/10.1038/s41467-020-17737-w Cite
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Toll-Like Receptor Dual-Acting Agonists Are Potent Inducers of PBMC-Produced Cytokines That Inhibit Hepatitis B Virus Production in Primary Human Hepatocytes

Researchers found that conditioned media (CM) from peripheral blood mononuclear cells (PBMCs) stimulated with dual-acting TLR7/8 and TLR2/7 agonists were more potent drivers of inhibition of hepatisis e and hepatitis s antigen secretion from hepatitis B virus-infected primary human hepatocytes than CM from PBMCs stimulated with single-acting TLR7 or TLR9 agonists.
[Scientific Reports]
Janovec, V., Hodek, J., Clarova, K., Hofman, T., Dostalik, P., Fronek, J., Chlupac, J., Chaperot, L., Durand, S., Baumert, T. F., Pichova, I., Lubyova, B., Hirsch, I., & Weber, J. (2020). Toll-like receptor dual-acting agonists are potent inducers of PBMC-produced cytokines that inhibit hepatitis B virus production in primary human hepatocytes. Scientific Reports, 10(1), 12767. https://doi.org/10.1038/s41598-020-69614-7 Cite
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Ascentage Pharma Announces First Patient Dosed in the Phase Ib Study of MDM2-p53 Inhibitor APG-115 as Single Agent and in Combinations for the Treatment of Hematologic Malignancies in China

Ascentage Pharma announced that the Phase Ib study of the company’s novel MDM2-p53 inhibitor candidate APG-115 as a single agent or in combinations for the treatment of Chinese patients with relapsed/refractory acute myeloid leukemia, or relapsed/progressed high/very high risk myelodysplastic syndrome has dosed its first patient in China.
[Ascentage Pharma]
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Experimental Infection of Hepatitis E Virus Induces Pancreatic Necroptosis in Miniature Pigs

The authors determined the chronological distribution of hepatitis E virus (HEV) in various tissues of HEV-challenged miniature pigs and to investigate the mechanisms underlying HEV-induced cell death in the pancreas and liver.
[Scientific Reports]
Jung, S., Seo, D. J., Yeo, D., Wang, Z., Min, A., Zhao, Z., Song, M., Choi, I.-S., Myoung, J., & Choi, C. (2020). Experimental infection of hepatitis E virus induces pancreatic necroptosis in miniature pigs. Scientific Reports, 10(1), 12022. https://doi.org/10.1038/s41598-020-68959-3 Cite
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Assembly Biosciences Announces FDA Fast Track Designation Granted to ABI-H2158 for the Treatment of Chronic Hepatitis B Virus Infection

Assembly Biosciences, Inc. have announced that the US FDA has granted Fast Track designation to ABI-H2158 (2158) for the treatment of patients with chronic hepatitis B infection. 2158 is Assembly’s second-generation core inhibitor, which is being evaluated in an ongoing global Phase II trial.
[Assembly Biosciences, Inc.]
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Enanta Pharmaceuticals Announces Clinical Trial Progress for EDP-514, its Lead Core Inhibitor for Hepatitis B Virus

Enanta Pharmaceuticals, Inc., a clinical-stage biotechnology company dedicated to creating small molecule drugs for viral infections and liver diseases, has announced advancements in its hepatitis B virus program evaluating EDP-514 across different patient populations.
[Enanta Pharmaceuticals, Inc.]
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Safety and Efficacy of Chimeric Antigen Receptor (CAR)-T-cell Therapy in Persons with Advanced B-Cell Cancers and Hepatitis B Virus-Infection

Scientists studied 70 subjects with advanced B-cell cancers receiving CAR-T-cell therapy, 12 of whom had chronic hepatitis B virus-infection (HBV) and 29 with resolved HBV-infection
[Leukemia]
Wang, Y., Liu, Y., Tan, X., Pan, B., Ge, J., Qi, K., … Xu, K. (2020). Safety and efficacy of chimeric antigen receptor (CAR)-T-cell therapy in persons with advanced B-cell cancers and hepatitis B virus-infection. Leukemia, 1–4. https://doi.org/10.1038/s41375-020-0936-4 Cite
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Assembly Biosciences Initiates Phase II Trial Evaluating Second-Generation Core Inhibitor ABI-H2158 for Chronic Hepatitis B Infection

Assembly Biosciences, Inc. have announced the initiation of a Phase II trial of their potent, second-generation core inhibitor, ABI-H2158, for patients with HBeAg positive chronic hepatitis B infection without cirrhosis.
[Assembly Biosciences, Inc.]
Press Release

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Plasma IP-10 and IL-6 Are Linked to Child-Pugh B Cirrhosis in Patients with Advanced HCV-Related Cirrhosis: A Cross-Sectional Study

Investigators carried out a cross-sectional study in 97 patients with advanced hepatitis C virus (HCV)-related cirrhosis. Plasma biomarkers were measured by ProcartaPlex multiplex immunoassays.
[Scientific Reports]
Salgüero, S., Medrano, L. M., González-García, J., Berenguer, J., Montes, M. L., Diéz, C., … Resino, S. (2020). Plasma IP-10 and IL-6 are linked to Child-Pugh B cirrhosis in patients with advanced HCV-related cirrhosis: a cross-sectional study. Scientific Reports, 10(1), 10384. https://doi.org/10.1038/s41598-020-67159-3 Cite
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Chronic Viral Liver Diseases: Approaching the Liver Using T Cell Receptor-Mediated Gene Technologies

Investigators give an overview of T cell receptors identified from viral hepatitis research and discuss how translational lessons learned from cancer immunotherapy can be applied to the field.
[Cells]
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