Investigators showed that inhibiting serpinB13, a cathepsin L protease inhibitor expressed in the pancreatic epithelium, caused in vitro and in vivo cleavage of the extracellular domain of Notch1.
[Science Translational Medicine]
Researchers used a cell-tagging dye, CFDA-SE, to permanently label pancreatic duct cells through an intraductal infusion technique.
[Experimental and Molecular Medicine]
6807162 PEJX75U7 items 1 apa default asc 1
Scientists identified preoperative plasma protein biomarkers with the potential to predict early recurrence after resection of PDAC.
6807162 NQDHEG3X items 1 apa default asc 1
Rittmann, M.-C., Hussung, S., Braun, L. M., Klar, R. F. U., Biesel, E. A., Fichtner-Feigl, S., Fritsch, R., Wittel, U. A., & Ruess, D. A. (2021). Plasma biomarkers for prediction of early tumor recurrence after resection of pancreatic ductal adenocarcinoma. Scientific Reports, 11(1), 7499. https://doi.org/10.1038/s41598-021-86779-x Cite
The role of miR-30d in the proliferation and metastasis of pancreatic cancer cells was determined using in vitro and in vivo assays.
[Cell Death & Disease]
6807162 LNGS6ZCY items 1 apa default asc 1
The authors showed that proliferative endothelial cells modulated macrophage (MΦ) infiltration and phenotype during β cell loss, and recruited MΦs were essential for β cell recovery.
[npj Regenerative Medicine]
6807162 5M5METU6 items 1 apa default asc 1
Saunders, D. C., Aamodt, K. I., Richardson, T. M., Hopkirk, A. J., Aramandla, R., Poffenberger, G., Jenkins, R., Flaherty, D. K., Prasad, N., Levy, S. E., Powers, A. C., & Brissova, M. (2021). Coordinated interactions between endothelial cells and macrophages in the islet microenvironment promote β cell regeneration. Npj Regenerative Medicine, 6(1), 1–13. https://doi.org/10.1038/s41536-021-00129-z Cite
The authors discuss the development of the most widely available insulin preparations and provide evidence-based insight into their use in clinical practice.
Investigators discuss current challenges surrounding the generation, delivery, and engraftment of stem cell-derived islet-like cells, along with strategies to induce durable tolerance to grafted cells, with an eye toward a functional cellular-based therapy enabling insulin independence for patients with diabetes.
Researchers observed state-specific enrichment of fasting glucose and type 2 diabetes genome-wide association studies for beta cells and enrichment for other endocrine cell types.
6606345 JPTGNYA5 items 1 apa default asc 1
Chiou, J., Zeng, C., Cheng, Z., Han, J. Y., Schlichting, M., Miller, M., Mendez, R., Huang, S., Wang, J., Sui, Y., Deogaygay, A., Okino, M.-L., Qiu, Y., Sun, Y., Kudtarkar, P., Fang, R., Preissl, S., Sander, M., Gorkin, D. U., & Gaulton, K. J. (2021). Single-cell chromatin accessibility identifies pancreatic islet cell type– and state-specific regulatory programs of diabetes risk. Nature Genetics, 1–12. https://doi.org/10.1038/s41588-021-00823-0 Cite
Scientists confirmed that mind bomb 1 (MIB1) expression was elevated in pancreatic cancer tissues and that high levels of MIB associate with unfavorable prognosis. Overexpression of MIB1 enhanced proliferation and invasion of pancreatic cancer cells both in vitro and in vivo.
6606345 B73SE5TY items 1 apa default asc 1
Zhang, B., Cheng, X., Zhan, S., Jin, X., & Liu, T. (n.d.). MIB1 upregulates IQGAP1 and promotes pancreatic cancer progression by inducing ST7 degradation. Molecular Oncology, n/a(n/a). https://doi.org/https://doi.org/10.1002/1878-0261.12955 Cite
The authors address the current molecular biological features for understanding the multifactorial function of PARP-1 in pancreatic cancer related to the aforementioned roles, along with the summary of recent approaches with PARP-1 inhibition in clinical studies targeting pancreatic cancer.
[International Journal of Molecular Sciences]
Investigators demonstrated successful encapsulation, spheroid formation and high viability for three different hPSC lines. Using one of the hPSC lines they demonstrated maintenance of pluripotency and successful differentiation of stem cell spheroids into β-cells.
6606345 SI2YKMD6 items 1 apa default asc 1
Fattahi, P., Rahimian, A., Slama, M. Q., Gwon, K., Gonzalez-Suarez, A. M., Wolf, J., Baskaran, H., Duffy, C. D., Stybayeva, G., Peterson, Q. P., & Revzin, A. (2021). Core–shell hydrogel microcapsules enable formation of human pluripotent stem cell spheroids and their cultivation in a stirred bioreactor. Scientific Reports, 11(1), 7177. https://doi.org/10.1038/s41598-021-85786-2 Cite