Aberrant Development of Pancreatic Beta Cells Derived from Human iPSCs with FOXA2 Deficiency

Researchers generated induced pluripotent stem cells (iPSCs) from a patient with FOXA2 haploinsufficiency followed by beta-cell differentiation to understand the role of FOXA2 during pancreatic beta-cell development.
[Cell Death & Disease]
Elsayed, A. K., Younis, I., Ali, G., Hussain, K., & Abdelalim, E. M. (2021). Aberrant development of pancreatic beta cells derived from human iPSCs with FOXA2 deficiency. Cell Death & Disease, 12(1), 1–17. https://doi.org/10.1038/s41419-021-03390-8 Cite
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Aberrant Development of Pancreatic Beta Cells Derived from Human iPSCs with FOXA2 Deficiency

Investigators generated iPSCs from a patient with FOXA2 haploinsufficiency followed by beta-cell differentiation to understand the role of FOXA2 during pancreatic beta-cell development.
[Cell Death & Disease]
Elsayed, A. K., Younis, I., Ali, G., Hussain, K., & Abdelalim, E. M. (2021). Aberrant development of pancreatic beta cells derived from human iPSCs with FOXA2 deficiency. Cell Death & Disease, 12(1), 1–17. https://doi.org/10.1038/s41419-021-03390-8 Cite
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Dopamine Improves Chemotherapeutic Efficacy for Pancreatic Cancer by Regulating Macrophage-Derived Inflammations

The roles and mechanisms of dopamine to affect the chemotherapeutic efficacy for pancreatic cancer were studied. Multi-omics results revealed that there was a tumor-promoting vicious cycle involving murine pancreatic cancer cells and tumor-associated macrophages.
[Cancer Immunology Immunotherapy]
Liu, Q., Zhang, R., Zhang, X., Liu, J., Wu, H., Li, Y., Cui, M., Li, T., Song, H., Gao, J., Zhang, Y., Yang, S., & Liao, Q. (2021). Dopamine improves chemotherapeutic efficacy for pancreatic cancer by regulating macrophage-derived inflammations. Cancer Immunology, Immunotherapy. https://doi.org/10.1007/s00262-020-02816-0 Cite
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SIX2 and SIX3 Coordinately Regulate Functional Maturity and Fate of Human Pancreatic β Cells

Scientists showed that shRNA-mediated SIX2 or SIX3 suppression in human pancreatic adult islets impaired insulin secretion.
[Genes & Development]
Bevacqua, R. J., Lam, J. Y., Peiris, H., Whitener, R. L., Kim, S., Gu, X., Friedlander, M. S. H., & Kim, S. K. (2021). SIX2 and SIX3 coordinately regulate functional maturity and fate of human pancreatic β cells. Genes & Development. https://doi.org/10.1101/gad.342378.120 Cite
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Combining NanoKnife with M1 Oncolytic Virus Enhances Anticancer Activity in Pancreatic Cancer

Scientists evaluated improvements to therapeutic efficacy through combination therapy incorporating NanoKnife and M1 virus. They showed that irreversible electroporation triggered reactive oxygen species-dependent apoptosis in pancreatic cancer cells mediated by phosphatidylinositol-3-kinase/protein kinase B pathway suppression.
[Cancer Letters]
Sun, S., Liu, Y., He, C., Hu, W., Liu, W., Huang, X., Wu, J., Xie, F., Chen, C., Wang, J., Lin, Y., Zhu, W., Yan, G., Cai, J., & Li, S. (2021). Combining NanoKnife with M1 oncolytic virus enhances anticancer activity in pancreatic cancer. Cancer Letters, 502, 9–24. https://doi.org/10.1016/j.canlet.2020.12.018 Cite
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A MET Targeting Antibody-Drug Conjugate Overcomes Gemcitabine Resistance in Pancreatic Cancer

Scientists evaluated the efficacy of TR1801-ADC, a newly developed ADC composed of a MET antibody conjugated to the highly potent pyrrolobenzodiazepine toxin-linker Tesirine. They first evaluated MET expression and subcellular localization in pancreatic cancer cell lines, human tumors and patient derived xenografts.
[Clinical Cancer Research]
Cazes, A., Betancourt, O., Esparza, E., Mose, E. S., Jaquish, D., Wong, E., Wascher, A. A., Tiriac, H., Gymnopoulos, M., & Lowy, A. M. (2021). A MET Targeting Antibody-Drug Conjugate Overcomes Gemcitabine Resistance in Pancreatic Cancer. Clinical Cancer Research. https://doi.org/10.1158/1078-0432.CCR-20-3210 Cite
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An Autophagy Enhancer Ameliorates Diabetes of Human IAPP-Transgenic Mice through Clearance of Amyloidogenic Oligomer

Researchers showed that a recently identified autophagy enhancer (MSL-7) reduces human IAPP oligomer accumulation in human iPSC-derived β-cells and diminishes oligomer-mediated apoptosis of β-cells.
[Nature Communications]
Kim, J., Park, K., Kim, M. J., Lim, H., Kim, K. H., Kim, S.-W., Lee, E.-S., Kim, H. (Henry), Kim, S. J., Hur, K. Y., Kim, J. H., Ahn, J. H., Yoon, K.-H., Kim, J.-W., & Lee, M.-S. (2021). An autophagy enhancer ameliorates diabetes of human IAPP -transgenic mice through clearance of amyloidogenic oligomer. Nature Communications, 12(1), 183. https://doi.org/10.1038/s41467-020-20454-z Cite
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TGFB1/INHBA homodimer/Nodal-SMAD2/3 Signaling Network: A Pivotal Molecular Target in PDAC Treatment

The authors focus on TGFB1/INHBA homodimer/Nodal-SMAD2/3 signaling network in pancreatic cancer as a pivotal central node which regulates multiple key mechanisms involved in the development of chemoresistance, including enhancement of the stem cell-like properties and tumorigenicity of pancreatic cancer cells, mediating cooperative interactions between pancreatic cancer cells and the surrounding stroma as well as regulating the deposition of ECM proteins within the tumor microenvironment.
[Molecular Therapy]
Mouti, M. A., & Pauklin, S. (2021). TGFB1/INHBA homodimer/Nodal-SMAD2/3 Signalling Network: A Pivotal Molecular Target in PDAC Treatment. Molecular Therapy, 0(0). https://doi.org/10.1016/j.ymthe.2021.01.002 Cite
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Adocia Files Patent on a Hydrogel Scaffold for Cell Therapy in the Treatment of Type 1 Diabetes

Adocia announced it has developed a hydrogel scaffold that hosts and protects pancreatic β cells for replacement of the missing cells of people with type 1 diabetes.
[Adocia]
Press Release
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Establishment of a Long-Term Stable β-Cell Line and Its Application To Analyze the Effect of Gcg Expression on Insulin Secretion

Scientists developed a stable β-cell line that retains the characteristics of mature β-cells.
[Scientific Reports]
Establishment of a long-term stable β-cell line and its application to analyze the effect of Gcg expression on insulin secretion | Scientific Reports. (n.d.). Retrieved January 12, 2021, from https://www.nature.com/articles/s41598-020-79992-7 Cite
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The EGFR-HSF1 Axis Accelerates the Tumorigenesis of Pancreatic Cancer

Investigators clarified the mechanisms on early activation of heat shock factor 1 (HSF1) and its role in the pancreatic cancer tumorigenesis.
[Journal of Experimental & Clinical Cancer Research]
Qian, W., Chen, K., Qin, T., Xiao, Y., Li, J., Yue, Y., Zhou, C., Ma, J., Duan, W., Lei, J., Han, L., Li, L., Shen, X., Wu, Z., Ma, Q., & Wang, Z. (2021). The EGFR-HSF1 axis accelerates the tumorigenesis of pancreatic cancer. Journal of Experimental & Clinical Cancer Research, 40(1), 25. https://doi.org/10.1186/s13046-020-01823-4 Cite
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