SerpinB13 Antibodies Promote β Cell Development and Resistance to Type 1 Diabetes

Investigators showed that inhibiting serpinB13, a cathepsin L protease inhibitor expressed in the pancreatic epithelium, caused in vitro and in vivo cleavage of the extracellular domain of Notch1.
[Science Translational Medicine]
Kryvalap, Y., Jiang, M. L., Kryvalap, N., Hendrickson, C., & Czyzyk, J. (2021). SerpinB13 antibodies promote β cell development and resistance to type 1 diabetes. Science Translational Medicine, 13(588). https://doi.org/10.1126/scitranslmed.abf1587 Cite
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Insulin-Positive Ductal Cells Do Not Migrate Into Preexisting Islets during Pregnancy

Researchers used a cell-tagging dye, CFDA-SE, to permanently label pancreatic duct cells through an intraductal infusion technique.
[Experimental and Molecular Medicine]
Liu, Q., Jiang, Y., Zhu, L., Qian, J., Wang, C., Yang, T., Prasadan, K., Gittes, G. K., & Xiao, X. (2021). Insulin-positive ductal cells do not migrate into preexisting islets during pregnancy. Experimental & Molecular Medicine, 1–10. https://doi.org/10.1038/s12276-021-00593-z Cite
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Plasma Biomarkers for Prediction of Early Tumor Recurrence after Resection of Pancreatic Ductal Adenocarcinoma

Scientists identified preoperative plasma protein biomarkers with the potential to predict early recurrence after resection of PDAC.
[Scientific Reports]
Rittmann, M.-C., Hussung, S., Braun, L. M., Klar, R. F. U., Biesel, E. A., Fichtner-Feigl, S., Fritsch, R., Wittel, U. A., & Ruess, D. A. (2021). Plasma biomarkers for prediction of early tumor recurrence after resection of pancreatic ductal adenocarcinoma. Scientific Reports, 11(1), 7499. https://doi.org/10.1038/s41598-021-86779-x Cite
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MiR-30d Suppresses Proliferation and Invasiveness of Pancreatic Cancer by Targeting the SOX4/PI3K-AKT Axis and Predicts Poor Outcome

The role of miR-30d in the proliferation and metastasis of pancreatic cancer cells was determined using in vitro and in vivo assays.
[Cell Death & Disease]
Xu, X., Zong, K., Wang, X., Dou, D., Lv, P., Zhang, Z., & Li, H. (2021). miR-30d suppresses proliferation and invasiveness of pancreatic cancer by targeting the SOX4/PI3K-AKT axis and predicts poor outcome. Cell Death & Disease, 12(4), 1–14. https://doi.org/10.1038/s41419-021-03576-0 Cite
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Coordinated Interactions between Endothelial Cells and Macrophages in the Islet Microenvironment Promote β Cell Regeneration

The authors showed that proliferative endothelial cells modulated macrophage (MΦ) infiltration and phenotype during β cell loss, and recruited MΦs were essential for β cell recovery.
[npj Regenerative Medicine]
Saunders, D. C., Aamodt, K. I., Richardson, T. M., Hopkirk, A. J., Aramandla, R., Poffenberger, G., Jenkins, R., Flaherty, D. K., Prasad, N., Levy, S. E., Powers, A. C., & Brissova, M. (2021). Coordinated interactions between endothelial cells and macrophages in the islet microenvironment promote β cell regeneration. Npj Regenerative Medicine, 6(1), 1–13. https://doi.org/10.1038/s41536-021-00129-z Cite
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Insulin and Insulin Analogs as Antidiabetic Therapy: A Perspective from Clinical Trials

The authors discuss the development of the most widely available insulin preparations and provide evidence-based insight into their use in clinical practice.
[Cell Metabolism]
Kramer, C. K., Retnakaran, R., & Zinman, B. (2021). Insulin and insulin analogs as antidiabetic therapy: A perspective from clinical trials. Cell Metabolism, 33(4), 740–747. https://doi.org/10.1016/j.cmet.2021.03.014 Cite
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Human Pluripotent Stem Cell-Derived Insulin-Producing Cells: A Regenerative Medicine Perspective

Investigators discuss current challenges surrounding the generation, delivery, and engraftment of stem cell-derived islet-like cells, along with strategies to induce durable tolerance to grafted cells, with an eye toward a functional cellular-based therapy enabling insulin independence for patients with diabetes.
[Cell Metabolism]
Migliorini, A., Nostro, M. C., & Sneddon, J. B. (2021). Human pluripotent stem cell-derived insulin-producing cells: A regenerative medicine perspective. Cell Metabolism, 33(4), 721–731. https://doi.org/10.1016/j.cmet.2021.03.021 Cite
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Single-Cell Chromatin Accessibility Identifies Pancreatic Islet Cell Type-and State-Specific Regulatory Programs of Diabetes Risk

Researchers observed state-specific enrichment of fasting glucose and type 2 diabetes genome-wide association studies for beta cells and enrichment for other endocrine cell types.
[Nature Genetics]
Chiou, J., Zeng, C., Cheng, Z., Han, J. Y., Schlichting, M., Miller, M., Mendez, R., Huang, S., Wang, J., Sui, Y., Deogaygay, A., Okino, M.-L., Qiu, Y., Sun, Y., Kudtarkar, P., Fang, R., Preissl, S., Sander, M., Gorkin, D. U., & Gaulton, K. J. (2021). Single-cell chromatin accessibility identifies pancreatic islet cell type– and state-specific regulatory programs of diabetes risk. Nature Genetics, 1–12. https://doi.org/10.1038/s41588-021-00823-0 Cite
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MIB1 Upregulates IQGAP1 and Promotes Pancreatic Cancer Progression by Inducing ST7 Degradation

Scientists confirmed that mind bomb 1 (MIB1) expression was elevated in pancreatic cancer tissues and that high levels of MIB associate with unfavorable prognosis. Overexpression of MIB1 enhanced proliferation and invasion of pancreatic cancer cells both in vitro and in vivo.
[Molecular Oncology]
Zhang, B., Cheng, X., Zhan, S., Jin, X., & Liu, T. (n.d.). MIB1 upregulates IQGAP1 and promotes pancreatic cancer progression by inducing ST7 degradation. Molecular Oncology, n/a(n/a). https://doi.org/https://doi.org/10.1002/1878-0261.12955 Cite
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The Significance of Targeting Poly (ADP-Ribose) Polymerase-1 in Pancreatic Cancer for Providing a New Therapeutic Paradigm

The authors address the current molecular biological features for understanding the multifactorial function of PARP-1 in pancreatic cancer related to the aforementioned roles, along with the summary of recent approaches with PARP-1 inhibition in clinical studies targeting pancreatic cancer.
[International Journal of Molecular Sciences]
IJMS | Free Full-Text | The Significance of Targeting Poly (ADP-Ribose) Polymerase-1 in Pancreatic Cancer for Providing a New Therapeutic Paradigm. (n.d.). Retrieved April 6, 2021, from https://www.mdpi.com/1422-0067/22/7/3509 Cite
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Core–Shell Hydrogel Microcapsules Enable Formation of Human Pluripotent Stem Cell Spheroids and Their Cultivation in a Stirred Bioreactor

Investigators demonstrated successful encapsulation, spheroid formation and high viability for three different hPSC lines. Using one of the hPSC lines they demonstrated maintenance of pluripotency and successful differentiation of stem cell spheroids into β-cells.
[Scientific Reports]
Fattahi, P., Rahimian, A., Slama, M. Q., Gwon, K., Gonzalez-Suarez, A. M., Wolf, J., Baskaran, H., Duffy, C. D., Stybayeva, G., Peterson, Q. P., & Revzin, A. (2021). Core–shell hydrogel microcapsules enable formation of human pluripotent stem cell spheroids and their cultivation in a stirred bioreactor. Scientific Reports, 11(1), 7177. https://doi.org/10.1038/s41598-021-85786-2 Cite
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