Induction of Cell Death in Pancreatic Tumors by Zinc and Its Florescence Chelator TSQ

Upon treatment with N,N,N′,N′-tetrakis(2-pyridinylmethyl)-1,2-ethanediamine, a zinc chelator, organoids degenerated and its negative effect was rescued by co-treatment with zinc, indicating that zinc is necessary for the growth and survival of tumor organoids.
[Biological Trace Element Research]
Asahina, K. (2021). Induction of Cell Death in Pancreatic Tumors by Zinc and Its Fluorescence Chelator TSQ. Biological Trace Element Research. https://doi.org/10.1007/s12011-021-02770-7 Cite
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Hypericin-Mediated Photodynamic Therapy Enhances Gemcitabine Induced Capan-2 Cell Apoptosis via Inhibiting NADPH Level

The activity of glutathione reductase and the levels of reduced glutathione and oxidised glutathione were assessed using assay kits.
[Journal of Pharmacy and Pharmacology]
Sun, L., Shang, H., Wu, Y., & Xin, X. (2021). Hypericin-mediated photodynamic therapy enhances gemcitabine induced Capan-2 cell apoptosis via inhibiting NADPH level. Journal of Pharmacy and Pharmacology, rgab073. https://doi.org/10.1093/jpp/rgab073 Cite
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T Cells Armed with C-X-C Chemokine Receptor Type 6 Enhance Adoptive Cell Therapy for Pancreatic Tumours

Researchers showed that forced expression of C-X-C chemokine receptor type 6 in antigen-specific T cells enhanced the recognition and lysis of pancreatic cancer cells and the efficacy of adoptive cell therapy for pancreatic cancer.
[Nature Biomedical Engineering]
Lesch, S., Blumenberg, V., Stoiber, S., Gottschlich, A., Ogonek, J., Cadilha, B. L., Dantes, Z., Rataj, F., Dorman, K., Lutz, J., Karches, C. H., Heise, C., Kurzay, M., Larimer, B. M., Grassmann, S., Rapp, M., Nottebrock, A., Kruger, S., Tokarew, N., … Kobold, S. (2021). T cells armed with C-X-C chemokine receptor type 6 enhance adoptive cell therapy for pancreatic tumours. Nature Biomedical Engineering, 1–15. https://doi.org/10.1038/s41551-021-00737-6 Cite
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Exosomal Linc-ROR Mediates Crosstalk between Cancer Cells and Adipocytes to Promote Tumor Growth in Pancreatic Cancer

The effects of conditioned medium collected from dedifferentiated adipocytes on pancreatic cancer cell proliferation, motility, metastasis and epithelial-mesenchymal transition (EMT) were evaluated by western blot analysis, colony forming, real-time cell analysis, 5-ethynyl-2’-deoxyuridine, immunofluorescence, Transwell and wound healing assays in vitro.
[Molecular Therapy-Nucleic Acids]
Sun, Z., Sun, D., Feng, Y., Zhang, B., Sun, P., Zhou, B., Du, L., Wang, Y., Fan, Z., Yang, J., Li, Y., Hu, S., & Zhan, H. (2021). Exosomal Linc-ROR Mediates Crosstalk between Cancer Cells and Adipocytes to Promote Tumor Growth in Pancreatic Cancer. Molecular Therapy - Nucleic Acids, 0(0). https://doi.org/10.1016/j.omtn.2021.06.001 Cite
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miR-194-5p Down-Regulates Tumor Cell PD-L1 Expression and Promotes Anti-tumor Immunity in Pancreatic Cancer

Investigators found that high expression of miR-194-5p in human pancreatic cancer patients is associated with a better survival rate, while increased expression of programmed cell death ligand 1 in human pancreatic cancer patients is associated with a worse survival rate.
[International Immunopharmacology]
miR-194-5p down-regulates tumor cell PD-L1 expression and promotes anti-tumor immunity in pancreatic cancer. (2021). International Immunopharmacology, 97, 107822. https://doi.org/10.1016/j.intimp.2021.107822 Cite
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Early Detection of Pancreatic Cancer Using DNA-Based Molecular Approaches

Investigators discuss and focus on the pathological and molecular features of precancerous lesions of the pancreas, including pancreatic intraepithelial neoplasia, intraductal papillary mucinous neoplasm and mucinous cystic neoplasm, which are target lesions of early detection approaches.
[Nature Reviews Gastroenterology & Hepatology]
Singhi, A. D., & Wood, L. D. (2021). Early detection of pancreatic cancer using DNA-based molecular approaches. Nature Reviews Gastroenterology & Hepatology, 1–12. https://doi.org/10.1038/s41575-021-00470-0 Cite
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The Pancreatic Cancer Genome Revisited

Given the vast developments within this field, scientists review the wide-ranging and most current information related to pancreatic cancer genomics with the goal of integrating this information into a unifying description of the life history of pancreatic cancer.
[Nature Reviews Gastroenterology & Hepatology]
Hayashi, A., Hong, J., & Iacobuzio-Donahue, C. A. (2021). The pancreatic cancer genome revisited. Nature Reviews Gastroenterology & Hepatology, 1–13. https://doi.org/10.1038/s41575-021-00463-z Cite
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T Cells Armed with C-X-C Chemokine Receptor Type 6 Enhance Adoptive Cell Therapy for Pancreatic Tumors

Scientists showed that forced expression of C-X-C chemokine receptor type 6 in antigen-specific T cells enhanced the recognition and lysis of pancreatic cancer cells and the efficacy of adoptive cell therapy for pancreatic cancer.
[Nature Biomedical Engineering]
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In Vitro Assessment of a Synergistic Combination of Gemcitabine and Zebularine in Pancreatic Cancer Cells

Reserachers investigated the effect of a cytidine deaminase inhibitor – Zebularine (Zeb) on anticancer activity of Gem in pancreatic cancer cell lines MiaPaCa-2, BxPC-3, and Panc-1. Zeb treatment synergistically increased Gem-induced cytotoxicity in all three pancreatic cancer cell lines.
[Experimental Cell Research]
In vitro assessment of a synergistic combination of Gemcitabine and Zebularine in pancreatic cancer cells. (2021). Experimental Cell Research, 112660. https://doi.org/10.1016/j.yexcr.2021.112660 Cite
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The Cell Line-Dependent Diversity in Initial Morphological Dynamics of Pancreatic Cancer Cell Peritoneal Metastasis Visualized by an Artificial Human Peritoneal Model

Panc-1 cells demonstrated the intermediate characteristics of MIA PaCa-2 and BxPC3 on AHPT.
[journal of surgical research]
Odagiri, T., Asano, Y., Kagiya, T., Matsusaki, M., Akashi, M., Shimoda, H., & Hakamada, K. (2021). The Cell Line-Dependent Diversity in Initial Morphological Dynamics of Pancreatic Cancer Cell Peritoneal Metastasis Visualized by an Artificial Human Peritoneal Model. Journal of Surgical Research, 261, 351–360. https://doi.org/10.1016/j.jss.2020.12.046 Cite
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Probiotic Aspergillus oryzae Produces Anti-Tumor Mediator and Exerts Anti-Tumor Effects in Pancreatic Cancer through the p38 MAPK Signaling Pathway

Investigators assessed the anti-tumor effects of probiotic bacteria against pancreatic cancer cells. Among the known probiotic bacteria, Aspergillus oryzae exhibited a strong pancreatic tumor suppression effect.
[Scientific Reports]
Konishi, H., Isozaki, S., Kashima, S., Moriichi, K., Ichikawa, S., Yamamoto, K., Yamamura, C., Ando, K., Ueno, N., Akutsu, H., Ogawa, N., & Fujiya, M. (2021). Probiotic Aspergillus oryzae produces anti-tumor mediator and exerts anti-tumor effects in pancreatic cancer through the p38 MAPK signaling pathway. Scientific Reports, 11(1), 11070. https://doi.org/10.1038/s41598-021-90707-4 Cite
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