The authors focus on three types of well-established ncRNAs — microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs) — and discuss their potential as diagnostic, prognostic and predictive biomarkers in pancreatic ductal adenocarcinoma.
[Seminars in Cancer Biology]
miR-124 or EZH2 was overexpressed in AsPC-1 and PANC1 cells. Then, the effects on cell viability, apoptosis, invasion, migration and epithelial mesenchymal transition were evaluated. The roles of miR-124 on the expression and function of EZH2 in pancreatic tumors were determined by dual luciferase reporter assay. Subsequently, miR-124 was transfected to bone marrow mesenchymal stromal cells (BM-MSCs), and the BM-MSCs derived exosomes were isolated and co-cultured with AsPC-1 and PANC1 cells, or injected into pancreatic cancer tumor-bearing mice.
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Apexigen, Inc. announced that the US FDA has granted orphan drug designation status to APX005M for the treatment of esophageal and gastroesophageal junction cancer and for the treatment of pancreatic cancer.
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The authors established a pancreatic tumor organoid biobank from well‐phenotyped cachectic and non‐cachectic patients to enable identification of tumor‐derived factors driving cancer cachexia.
[Journal of Cachexia Sarcopenia and Muscle]
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Vaes, R. D. W., Dijk, D. P. J. van, Welbers, T. T. J., Blok, M. J., Aberle, M. R., Heij, L., Boj, S. F., Damink, S. W. M. O., & Rensen, S. S. (n.d.). Generation and initial characterization of novel tumour organoid models to study human pancreatic cancer-induced cachexia. Journal of Cachexia, Sarcopenia and Muscle, n/a(n/a). https://doi.org/10.1002/jcsm.12627 Cite
Organoids are an ideal preclinical platform to study intraductal papillary mucinous neoplasms (IPMNs), and the objective of the current investigation was to establish a living biobank of patient-derived organoids from IPMNs.
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Beato, F., Reverón, D., Dezsi, K. B., Ortiz, A., Johnson, J. O., Chen, D.-T., Ali, K., Yoder, S. J., Jeong, D., Malafa, M., Hodul, P., Jiang, K., Centeno, B. A., Abdalah, M. A., Balasi, J. A., Tassielli, A. F., Sarcar, B., Teer, J. K., DeNicola, G. M., … Fleming, J. B. (2020). Establishing a living biobank of patient-derived organoids of intraductal papillary mucinous neoplasms of the pancreas. Laboratory Investigation, 1–14. https://doi.org/10.1038/s41374-020-00494-1 Cite
Scientists interrogated the transcriptome, genome, proteome and functional characteristics of 61 novel pancreatic cancer patient-derived cell lines to define novel therapeutic strategies targeting DDR and replication stress. Validation was done in patient derived xenografts and human PC organoids.
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Dreyer, S. B., Upstill-Goddard, R., Paulus-Hock, V., Paris, C., Lampraki, E.-M., Dray, E., Serrels, B., Caligiuri, G., Rebus, S., Plenker, D., Galluzzo, Z., Brunton, H., Cunningham, R., Tesson, M., Nourse, C., Bailey, U.-M., Jones, M., Moran-Jones, K., Wright, D. W., … Chang, D. K. (2020). Targeting DNA Damage Response and Replication Stress in Pancreatic Cancer. Gastroenterology. https://doi.org/10.1053/j.gastro.2020.09.043 Cite
Nanobiotix announced that the first patient has been injected in its phase I study evaluating NBTXR3 activated by radiation therapy for patients with pancreatic cancer.
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Investigators used sublines to screen molecular targets for the treatment of pancreatic cancer. Among the genes with increased expression levels in the sublines, they focused on those encoding cell surface receptors that may be involved in the interactions between cancer cells and the tumor microenvironment.
The authors analyze the role of cancer associated fibroblasts (CAFs) in therapeutic resistance of pancreatic cancer and discuss potential CAFs-targeting strategies basing on the diverse biological functions of CAFs, thus to improve the outcome of pancreatic cancer treatment.
[Biochimica et Biophysica Acta-Reviews On Cancer]
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Han, X., Zhang, W.-H., Wang, W.-Q., Yu, X.-J., & Liu, L. (2020). Cancer-associated fibroblasts in therapeutic resistance of pancreatic cancer: Present situation, predicaments, and perspectives. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 1874(2), 188444. https://doi.org/10.1016/j.bbcan.2020.188444 Cite
Researchers investigated the potential role and mechanism of calreticulin in regulating intracellular free Ca2+ dependent acute and chronic endoplasmic reticulum stress-induced epithelial-mesenchymal transition in pancreatic camcer in vitro and vivo.
[Journal of Experimental & Clinical Cancer Research]
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Sheng, W., Wang, G., Tang, J., Shi, X., Cao, R., Sun, J., Lin, Y. H., Jia, C., Chen, C., Zhou, J., & Dong, M. (2020). Calreticulin promotes EMT in pancreatic cancer via mediating Ca2+ dependent acute and chronic endoplasmic reticulum stress. Journal of Experimental & Clinical Cancer Research, 39(1), 209. https://doi.org/10.1186/s13046-020-01702-y Cite
The effects of systemic administration of Porphyromonas gingivalis lipopolysaccharide on gene expression were comprehensively explored in mouse pancreas that did not demonstrate any signs of inflammation.
[International Journal of Molecular Sciences]
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Hiraki, D., Uehara, O., Kuramitsu, Y., Morikawa, T., Harada, F., Yoshida, K., Akino, K., Chiba, I., Asaka, M., & Abiko, Y. (2020). P. gingivalis Lipopolysaccharide Stimulates the Upregulated Expression of the Pancreatic Cancer-Related Genes Regenerating Islet-Derived 3 A/G in Mouse Pancreas. International Journal of Molecular Sciences, 21(19), 7351. https://doi.org/10.3390/ijms21197351 Cite