PAF1 Regulates Stem Cell Features of Pancreatic Cancer Cells, Independently of the PAF1 Complex, via Interactions with PHF5A and DDX3

Researchers investigated mechanisms by which PAF1 maintains cancer stem cells and contributes to development of pancreatic tumors.
[Gastroenterology]
Karmakar, S., Rauth, S., Nallasamy, P., Perumal, N., Nimmakalaya, R. K., Leon, F., Gupta, R., Barkeer, S., Venkata, R. C., Raman, V., Rachagani, S., Ponnusamy, M. P., & Batra, S. K. (2020). PAF1 Regulates Stem Cell Features of Pancreatic Cancer Cells, Independently of the PAF1 Complex, via Interactions with PHF5A and DDX3. Gastroenterology, 0(0). https://doi.org/10.1053/j.gastro.2020.07.053 Cite
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Loss of HIF1A from Pancreatic Cancer Cells Increases Expression of PPP1R1B and Degradation of p53 to Promote Invasion and Metastasis

Scientists studied the roles of hypoxia inducible factor 1 alpha (HIF1A) in development of pancreatic tumors in mice. Cancer cells were cultured from pancreatic ductal adenocarcinomas from mice and analyzed in cell migration and invasion assays and by immunoblots, real-time PCR, and liquid chromatography–mass spectrometry.
[Gastroenterology]
Tiwari, A., Tashiro, K., Dixit, A., Soni, A., Vogel, K., Hall, B., Shafqat, I., Slaughter, J., Param, N., Le, A., Saunders, E., Paithane, U., Garcia, G., Campos, A. R., Zettervall, J., Carlson, M., Starr, T. K., Marahrens, Y., Deshpande, A. J., … Bagchi, A. (2020). Loss of HIF1A From Pancreatic Cancer Cells Increases Expression of PPP1R1B and Degradation of p53 to Promote Invasion and Metastasis. Gastroenterology, 0(0). https://doi.org/10.1053/j.gastro.2020.07.046 Cite
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Low Glucose Enhanced Metformin’s Inhibitory Effect on Pancreatic Cancer Cells by Suppressing Glycolysis and Inducing Energy Stress via Up-Regulation of miR-210-5p

To explore mechanisms underlying the discrepancy in anti-tumor effects of metformin on pancreatic cancer cells PANC-1 under different glucose conditions, investigators cultured PANC-1 cells in 25 mM and 5 mM glucose media, then treated with or without metformin.
[Cell Cycle]
Ma, M., Ma, C., Li, P., Ma, C., Ping, F., Li, W., Xu, L., Zhang, H., Sun, Q., & Li, Y. (2020). Low glucose enhanced metformin’s inhibitory effect on pancreatic cancer cells by suppressing glycolysis and inducing energy stress via up-regulation of miR-210-5p. Cell Cycle, 0(0), 1–14. https://doi.org/10.1080/15384101.2020.1796036 Cite
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PharmaCyte Biotech Ready to Submit Investigational New Drug Application to FDA for Clinical Trial in Pancreatic Cancer

PharmaCyte Biotech has reached what can only be described as a momentous milestone in its history and what should be considered a remarkable moment for any small biotech—the submission of an Investigational New Drug Application to the US FDA. This upcoming interaction with the FDA to request a planned Phase IIb clinical trial in locally advanced, inoperable pancreatic cancer is the product of years of meticulous work and dedication to the development of a treatment for the third leading cause of cancer-related deaths in the US.
[Pharmacyte Biotech]
Press Release

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Aptamers: A Novel Targeted Theranostic Platform for Pancreatic Ductal Adenocarcinoma

The authors summarize the generation process of aptamers and their application as biosensors, biomarker detection tools, targeted imaging tracers, and drug-delivery carriers. They discuss the current implementation aptamers in clinical trials, their limitations and possible future utilization, with a focus on pancreatic ductal adenocarcinoma.
[Radiation Oncology]
Li, Q., Maier, S. H., Li, P., Peterhansl, J., Belka, C., Mayerle, J., & Mahajan, U. M. (2020). Aptamers: a novel targeted theranostic platform for pancreatic ductal adenocarcinoma. Radiation Oncology, 15(1), 189. https://doi.org/10.1186/s13014-020-01624-1 Cite
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miR-324-5p Contributes to Cell Proliferation and Apoptosis in Pancreatic Cancer by Targeting KLF3

The authors report that miR-324-5p regulated the proliferation and apoptosis of pancreatic cancer cells through regulating the expression of KLF3.
[Molecular Therapy-Oncolytics]
Wan, Y., Luo, H., Yang, M., Tian, X., Peng, B., Zhan, T., Chen, X., Ding, Y., He, J., Cheng, X., Huang, X., & Zhang, Y. (2020). miR-324-5p contributes to cell proliferation and apoptosis in pancreatic cancer by targeting KLF3. Molecular Therapy - Oncolytics, 0(0). https://doi.org/10.1016/j.omto.2020.07.011 Cite
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GINS2 Promotes EMT in Pancreatic Cancer via Specifically Stimulating ERK/MAPK Signaling

Investigators found that overexpression of Go-Ichi-Ni-San 2 (GINS2) contributed to advanced clinical stage of pancreatic cancer patient and promoted epithelial–mesenchymal-transition in vitro and in vivo via specifically activating ERK/MAPK signal pathway.
[Cancer Gene Therapy]
Huang, L., Chen, S., Fan, H., Ji, D., Chen, C., & Sheng, W. (2020). GINS2 promotes EMT in pancreatic cancer via specifically stimulating ERK/MAPK signaling. Cancer Gene Therapy, 1–11. https://doi.org/10.1038/s41417-020-0206-7 Cite
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Mucins in Pancreatic Cancer: A Well‐Established but Promising Family for Diagnosis, Prognosis and Therapy

The authors discuss the important roles of mucins that lead to the lethality of pancreatic adenocarcinoma, particularly MUC1, MUC4, MUC5AC and MUC16 in disease progression, and present a comprehensive analysis of the clinical application of mucins and their promising roles in cancer treatment.
[Journal of Cellular and Molecular Medicine]
Mucins in pancreatic cancer: A well‐established but promising family for diagnosis, prognosis and therapy - Wang - - Journal of Cellular and Molecular Medicine - Wiley Online Library. (n.d.). Retrieved August 4, 2020, from https://onlinelibrary.wiley.com/doi/full/10.1111/jcmm.15684 Cite
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TYME Announces Orphan Drug Designation for SM-88 as Potential Treatment for Patients with Pancreatic Cancer

Tyme Technologies, Inc. announced that the FDA has granted the company Orphan Drug Designation for its lead pipeline candidate, SM-88, as a potential treatment for patients with pancreatic cancer.
[TYME Inc.]
Press Release

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High-Dimensional Single-Cell Analysis Delineates Radiofrequency Ablation Induced Immune Microenvironmental Remodeling in Pancreatic Cancer

Investigators indicated that radiofrequency ablation (RFA) treatment induced remodeling of tumor immune microenvironment in distant non-RFA tumors in pancreatic cancer mouse model.
[Cell Death & Disease]
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Invasion Inhibition in Pancreatic Cancer using the Oral Iron Chelating Agent Deferasirox

Researchers used pancreatic cancer cell lines (BxPC-3, Panc-1, and HPAF II) to examine the efficacy of iron chelator deferasirox in preventing invasion in vitro, evaluated using scratch assays and Boyden chamber assays.
[BMC Cancer]
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CircRHOT1 Mediated Cell Proliferation, Apoptosis and Invasion of Pancreatic Cancer Cells by Sponging miR-125a-3p

Investigators demonstrated that circRHOT1 was overexpressed in pancreatic cancer tissues and cell lines, and it was found to directly bind to miR‐125a‐3p, acting as an endogenous sponge to inhibit its activity.
[Journal of Cellular and Molecular Medicine]
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