Using in vitro and in vivo pancreatic cancer models, scientists showed that IDO1 expression was highly context dependent, influenced by attachment-independent growth and the canonical activator IFNγ.
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Newman, A. C., Falcone, M., Uribe, A. H., Zhang, T., Athineos, D., Pietzke, M., Vazquez, A., Blyth, K., & Maddocks, O. D. K. (2021). Immune-regulated IDO1-dependent tryptophan metabolism is source of one-carbon units for pancreatic cancer and stellate cells. Molecular Cell, 0(0). https://doi.org/10.1016/j.molcel.2021.03.019 Cite
Investigators demonstrated that Lipocalin 2 (LCN2) was robustly upregulated in murine models of pancreatic cancer, its expression is associated with reduced food consumption, and Lcn2 deletion is protective from cachexia-anorexia.
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Olson, B., Zhu, X., Norgard, M. A., Levasseur, P. R., Butler, J. T., Buenafe, A., Burfeind, K. G., Michaelis, K. A., Pelz, K. R., Mendez, H., Edwards, J., Krasnow, S. M., Grossberg, A. J., & Marks, D. L. (2021). Lipocalin 2 mediates appetite suppression during pancreatic cancer cachexia. Nature Communications, 12(1), 2057. https://doi.org/10.1038/s41467-021-22361-3 Cite
The role of miR-30d in the proliferation and metastasis of pancreatic cancer cells was determined using in vitro and in vivo assays.
[Cell Death & Disease]
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Researchers report a novel role of regulator of calcineurin 1, isoform 4 in regulating PDAC progression.
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Lao, M., Zhang, X., Ma, T., Xu, J., Yang, H., Duan, Y., Ying, H., Zhang, X., Guo, C., Qiu, J., Bai, X., & Liang, T. (2021). Regulator of calcineurin 1 gene isoform 4 in pancreatic ductal adenocarcinoma regulates the progression of tumor cells. Oncogene, 1–16. https://doi.org/10.1038/s41388-021-01763-z Cite
Bluestar Genomics announced it has received FDA Breakthrough Device designation for its proprietary noninvasive pancreatic cancer detection test in patients with new-onset diabetes.
[Bluestar Genomics (Business Wire, Inc.)]
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Scientists confirmed that mind bomb 1 (MIB1) expression was elevated in pancreatic cancer tissues and that high levels of MIB associate with unfavorable prognosis. Overexpression of MIB1 enhanced proliferation and invasion of pancreatic cancer cells both in vitro and in vivo.
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Zhang, B., Cheng, X., Zhan, S., Jin, X., & Liu, T. (n.d.). MIB1 upregulates IQGAP1 and promotes pancreatic cancer progression by inducing ST7 degradation. Molecular Oncology, n/a(n/a). https://doi.org/https://doi.org/10.1002/1878-0261.12955 Cite
FGD5-AS1 accelerated cell proliferation and migration via sponging miR-520a-3p and upregulating KIAA1522.
[Cancer Biology & Therapy]
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The authors address the current molecular biological features for understanding the multifactorial function of PARP-1 in pancreatic cancer related to the aforementioned roles, along with the summary of recent approaches with PARP-1 inhibition in clinical studies targeting pancreatic cancer.
[International Journal of Molecular Sciences]
Investigators describe a detailed alternative method to cultivate millimeter-scale functional vascularized tissues on a biofabricated platform that enabled facile incorporation of organoid technology.
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Lai, B. F. L., Lu, R. X. Z., Davenport Huyer, L., Kakinoki, S., Yazbeck, J., Wang, E. Y., Wu, Q., Zhang, B., & Radisic, M. (2021). A well plate–based multiplexed platform for incorporation of organoids into an organ-on-a-chip system with a perfusable vasculature. Nature Protocols, 1–32. https://doi.org/10.1038/s41596-020-00490-1 Cite
It was initially confirmed that escin, at concentrations >10 µM, significantly inhibited the proliferation of several pancreatic cancer cell lines.
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Omi, K., Matsuo, Y., Ueda, G., Aoyama, Y., Kato, T., Hayashi, Y., Imafuji, H., Saito, K., Tsuboi, K., Morimoto, M., Ogawa, R., Takahashi, H., & Takiguchi, S. (2021). Escin inhibits angiogenesis by suppressing interleukin‑8 and vascular endothelial growth factor production by blocking nuclear factor‑κB activation in pancreatic cancer cell lines. Oncology Reports, 45(5), 1–9. https://doi.org/10.3892/or.2021.8006 Cite
Scientists compared PANC-1 and MIA PaCa-2 pancreatic cancer cells which are, respectively, resistant and sensitive to MEK- and PI3K-targeted therapy.
[Biochemical and Biophysical Research Communications]
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Aguilar-Valdés, A., Noriega, L. G., Tovar, A. R., Ibarra-Sánchez, M. de J., Sosa-Hernández, V. A., Maravillas-Montero, J. L., & Martínez-Aguilar, J. (2021). SWATH-MS proteomics of PANC-1 and MIA PaCa-2 pancreatic cancer cells allows identification of drug targets alternative to MEK and PI3K inhibition. Biochemical and Biophysical Research Communications, 552, 23–29. https://doi.org/10.1016/j.bbrc.2021.03.018 Cite