CBX3 Antagonizes IFNγ/STAT1/PD-L1 Axis to Modulate Colon Inflammation and CRC Chemosensitivity

The authors revealed that the epigenetic regulator, chromobox protein homolog 3 (CBX3) antagonized IFNγ signaling in the colon epithelium by transcriptionally repressing two critical IFNγ-responsive genes: STAT1 and CD274.