MAPK

[Molecular Cancer Research] Researchers found that the expression of DCLK1 isoform 4 (DCLK1-S) was significantly increased in human esophageal squamous cell carcinoma tissues and associated with malignant progression and poor prognosis.

[Molecular Medicine Reports] RO 48‑8071 (RO) was used to treat the pancreatic cancer cell line in vitro to examine the effects of RO on cell viability, as well as to determine its potential molecular mechanism.

[Journal of Cardiovascular Pharmacology] Researchers found that NAMPT overexpression protected human coronary artery endothelial cells from H2O2-induced injury through promoting cell viability, inhibiting cell apoptosis, enhancing cell motility, and promoting tube formation.

[Cell Death Discovery] Researchers showed that the transcripts of Gadd45 family genes, including Gadd45a, Gadd45b, and Gadd45g, were gradually increased upon mouse ESC differentiation. Upregulation of Gadd45 members decreased cell proliferation and induced endodermal and trophectodermal lineages.

[Science Advances] The authors examined the molecular mechanisms coordinating the naïve to primed transition by using inducible ESC to genetically eliminate all RAS proteins. They showed that differentiated RASKO ESCs remained trapped in an intermediate state of pluripotency with naïve-associated features.

[Bone Marrow Transplantation] Further preclinical and clinical studies will explore defibrotide’s potential utility in a broader range of disorders resulting from endothelial cell activation and dysfunction.