MAPK

[Oncogene] In vitro experiments showed that a subset of combination therapy melanoma cells was sensitive to mTORC1 inhibition.

[Cell Biochemistry and Biophysics] Scientists showed that treatment with burn serum could significantly upregulate the phosphorylation level of extracellular signal-regulated kinase, p38, and c-Jun N-terminal kinase and the expression of cleaved caspase-3 and downregulated the expression of Bcl2 when compared with those in negative control of small interfering RNA transfected H9C2 cells

[Clinical Cancer Research] Scientists performed transcriptional profiling of tumors from a Phase II clinical trial of platinum chemotherapy for advanced TNBC, revealing a gene expression signature that identified de novo chemorefractory tumors.

[Biology of Reproduction] Researchers elucidated and compared the effects of bisphenol A (BPA) and BPS on physiological functions of HTR-8/SVneo cells, derived from extravillous trophoblast of first-trimester pregnancy.

[Laboratory Investigation] Rats induced with adjuvant arthritis and human primary synovial fibroblasts were used in vivo and in vitro to investigate the role of acid-sensing ion channel 1a (ASIC1a) in the proliferation of rheumatoid arthritis synovial fibroblasts.

[NPJ Genomic Medicine] Researchers provided a catalog of driver genes in cutaneous squamous cell carcinoma, offering points of therapeutic intervention and insights into the biology of cutaneous squamous cell carcinoma.