MTOR

[Science Immunology] Investigators reported a critical role of SLAM family receptors, ubiquitously expressed on hematopoietic cells and forming homotypic interactions, in constraining macrophage phagocytosis.

[Environmental Toxicology] Investigators studied the effect of co-treatment of caffeic acid phenethyl ester (CAPE) and gamma radiation on androgen-independent DU145 and PC3 cells. The combination treatment sensitized prostate cancer cells to radiation in a dose-dependent manner. The radiosensitizing effect of CAPE was observed in both cell lines.

[Cancer & Metabolism] As cholesterol is a key substrate for de novo steroidogenesis in prostate cells, researchers hypothesized that castrate-resistant/advanced prostate cancer cell growth was influenced by the availability of extracellular, low-density lipoprotein (LDL)-derived, cholesterol, which was coupled to intracellular cholesteryl ester homeostasis.

[Cancer Research] Three metastasis-associated circRNAs identified in a previous circRNA-sequencing study were screened and validated in two hepatocellular carcinoma (HCC) cohorts. CircRPN2 was downregulated in highly metastatic HCC cell lines and HCC tissues with metastasis.

[Nature] Investigators used brain organoids to show that although sex chromosomal complement had no observable effect on neurogenesis, sex steroids—namely androgens—led to increased proliferation of cortical progenitors and an increased neurogenic pool.

[Clinical and Translational Medicine] Rescue assays of cells overexpressing Metastasis-related in colon cancer 1 (MACC1)-AS1 and of cells silencing MACC1 were performed and cellular properties and proteins were assessed by the above-mentioned assays as well.